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One year of abaloparatide, a selective peptide activator of the PTH1 receptor, increased bone mass and strength in ovariectomized rats.
Varela A, Chouinard L, Lesage E, Guldberg R, Smith SY, Kostenuik PJ, Hattersley G. Varela A, et al. Among authors: kostenuik pj. Bone. 2017 Feb;95:143-150. doi: 10.1016/j.bone.2016.11.027. Epub 2016 Nov 25. Bone. 2017. PMID: 27894941 Free article.
These data indicate that gains in cortical and trabecular bone mass with abaloparatide are accompanied by and correlated with improvements in bone strength, resulting in maintenance or improvement in bone quality. Thus, this study demonstrated that long-term daily administ …
These data indicate that gains in cortical and trabecular bone mass with abaloparatide are accompanied by and correlated with improvements i …
Sustained Modeling-Based Bone Formation During Adulthood in Cynomolgus Monkeys May Contribute to Continuous BMD Gains With Denosumab.
Ominsky MS, Libanati C, Niu QT, Boyce RW, Kostenuik PJ, Wagman RB, Baron R, Dempster DW. Ominsky MS, et al. Among authors: kostenuik pj. J Bone Miner Res. 2015 Jul;30(7):1280-9. doi: 10.1002/jbmr.2480. J Bone Miner Res. 2015. PMID: 25684625 Free article.
Thus, this study provides preclinical evidence for a potential mechanism that could contribute to the clinical observations of continued BMD increases and low fracture rates with long-term DMAb administration....
Thus, this study provides preclinical evidence for a potential mechanism that could contribute to the clinical observations of continued BMD …
Temporal changes in systemic and local expression of bone turnover markers during six months of sclerostin antibody administration to ovariectomized rats.
Stolina M, Dwyer D, Niu QT, Villasenor KS, Kurimoto P, Grisanti M, Han CY, Liu M, Li X, Ominsky MS, Ke HZ, Kostenuik PJ. Stolina M, et al. Among authors: kostenuik pj. Bone. 2014 Oct;67:305-13. doi: 10.1016/j.bone.2014.07.031. Epub 2014 Aug 2. Bone. 2014. PMID: 25093263
We investigated the effects of Scl-Ab in mature ovariectomized (OVX) rats with a mechanistic focus on longer-term responses of osteoclasts, osteoblasts and osteocytes. Four-month-old Sprague-Dawley rats had OVX or sham surgery. ...
We investigated the effects of Scl-Ab in mature ovariectomized (OVX) rats with a mechanistic focus on longer-term responses of osteoc …
One year of transgenic overexpression of osteoprotegerin in rats suppressed bone resorption and increased vertebral bone volume, density, and strength.
Ominsky MS, Stolina M, Li X, Corbin TJ, Asuncion FJ, Barrero M, Niu QT, Dwyer D, Adamu S, Warmington KS, Grisanti M, Tan HL, Ke HZ, Simonet WS, Kostenuik PJ. Ominsky MS, et al. Among authors: kostenuik pj. J Bone Miner Res. 2009 Jul;24(7):1234-46. doi: 10.1359/jbmr.090215. J Bone Miner Res. 2009. PMID: 19257823 Free article.
Transgenic (Tg) rats were engineered to continuously overexpress OPG to study the effects of continuous long-term RANKL inhibition on bone volume, density, and strength. Lumbar vertebrae, femurs, and blood were obtained from 1-yr-old female OPG-Tg rats (n = 32) and from ag …
Transgenic (Tg) rats were engineered to continuously overexpress OPG to study the effects of continuous long-term RANKL inhibition on …
Gene therapy with human recombinant osteoprotegerin reverses established osteopenia in ovariectomized mice.
Kostenuik PJ, Bolon B, Morony S, Daris M, Geng Z, Carter C, Sheng J. Kostenuik PJ, et al. Bone. 2004 Apr;34(4):656-64. doi: 10.1016/j.bone.2003.12.006. Bone. 2004. PMID: 15050896
Osteoporosis is a chronic condition that is typically treated by the long-term repeated administration of antiresorptive agents. Gene therapy has the potential to deliver protein-based antiresorptive agents without the need for repeated administration. ...
Osteoporosis is a chronic condition that is typically treated by the long-term repeated administration of antiresorptive agents. Gene …
Genetic models in applied physiology: selected contribution: effects of spaceflight on immunity in the C57BL/6 mouse. II. Activation, cytokines, erythrocytes, and platelets.
Gridley DS, Nelson GA, Peters LL, Kostenuik PJ, Bateman TA, Morony S, Stodieck LS, Lacey DL, Simske SJ, Pecaut MJ. Gridley DS, et al. Among authors: kostenuik pj. J Appl Physiol (1985). 2003 May;94(5):2095-103. doi: 10.1152/japplphysiol.01053.2002. Epub 2002 Dec 27. J Appl Physiol (1985). 2003. PMID: 12506046 Free article.
These data indicate that relatively short exposure to the spaceflight environment can induce profound changes that may become significant during long-term space missions....
These data indicate that relatively short exposure to the spaceflight environment can induce profound changes that may become significant du …