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Small Substrate or Large? Debate Over the Mechanism of Glycation Adduct Repair by DJ-1.
Jun YW, Kool ET. Jun YW, et al. Among authors: kool et. Cell Chem Biol. 2020 Sep 17;27(9):1117-1123. doi: 10.1016/j.chembiol.2020.07.016. Epub 2020 Aug 11. Cell Chem Biol. 2020. PMID: 32783963 Free PMC article. Review.
Glycation, the term for non-enzymatic covalent reactions between aldehyde metabolites and nucleophiles on biopolymers, results in deleterious cellular damage and diseases. ...
Glycation, the term for non-enzymatic covalent reactions between aldehyde metabolites and nucleophiles on biopolymers, results in del …
A new four-base genetic helix, yDNA, composed of widened benzopyrimidine-purine pairs.
Lee AH, Kool ET. Lee AH, et al. Among authors: kool et. J Am Chem Soc. 2005 Mar 16;127(10):3332-8. doi: 10.1021/ja0430604. J Am Chem Soc. 2005. PMID: 15755149
We describe the properties of stable DNA-like self-assembled helices composed entirely of base pairs involving two new size-expanded pyrimidines. We term this new helix geometry "yDNA" (an abbreviation of "wide DNA"). ...
We describe the properties of stable DNA-like self-assembled helices composed entirely of base pairs involving two new size-expanded pyrimid …
Novel benzopyrimidines as widened analogues of DNA bases.
Lee AH, Kool ET. Lee AH, et al. Among authors: kool et. J Org Chem. 2005 Jan 7;70(1):132-40. doi: 10.1021/jo0483973. J Org Chem. 2005. PMID: 15624915
Their bases are benzo-homologated variants of thymine and cytosine and have a design that is distinct from a previously described class of size-expanded (xDNA) pyrimidines, with a different vector of expansion relative to the sugar. We term this new base geometry "yDNA" (a …
Their bases are benzo-homologated variants of thymine and cytosine and have a design that is distinct from a previously described class of s …