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DEPTOR modulates activation responses in CD4+ T cells and enhances immunoregulation following transplantation.
Wedel J, Bruneau S, Liu K, Kong SW, Sage PT, Sabatini DM, Laplante M, Briscoe DM. Wedel J, et al. Among authors: kong sw. Am J Transplant. 2019 Jan;19(1):77-88. doi: 10.1111/ajt.14995. Epub 2018 Aug 17. Am J Transplant. 2019. PMID: 29969188 Free PMC article.
In vivo, fully MHC mismatched cardiac allograft survival is significantly prolonged in knock-in recipients and sustained recipient expression of DEPTOR in combination with costimulatory blockade induces long-term graft survival. Furthermore, we show that the induced expres …
In vivo, fully MHC mismatched cardiac allograft survival is significantly prolonged in knock-in recipients and sustained recipient expressio …
An Efficient Search Algorithm for Finding Genomic-Range Overlaps Based on the Maximum Range Length.
Seok HS, Song T, Kong SW, Hwang KB. Seok HS, et al. Among authors: kong sw. IEEE/ACM Trans Comput Biol Bioinform. 2015 Jul-Aug;12(4):778-84. doi: 10.1109/TCBB.2014.2369042. IEEE/ACM Trans Comput Biol Bioinform. 2015. PMID: 26357316
., exons) has time complexity of O(k + logN), where kdenotes a term related to the length and location of the reference ranges. ...
., exons) has time complexity of O(k + logN), where kdenotes a term related to the length and location of the reference ranges. ...
Divergent dysregulation of gene expression in murine models of fragile X syndrome and tuberous sclerosis.
Kong SW, Sahin M, Collins CD, Wertz MH, Campbell MG, Leech JD, Krueger D, Bear MF, Kunkel LM, Kohane IS. Kong SW, et al. Mol Autism. 2014 Feb 24;5(1):16. doi: 10.1186/2040-2392-5-16. Mol Autism. 2014. PMID: 24564913 Free PMC article.
In the cerebellum of the Fmr1 knockout (Fmr1-KO) model, the neuroactive ligand receptor interaction pathway and gene sets associated with synaptic plasticity such as long-term potentiation, gap junction, and axon guidance were the most significantly perturbed pathways. ...
In the cerebellum of the Fmr1 knockout (Fmr1-KO) model, the neuroactive ligand receptor interaction pathway and gene sets associated with sy …
Characteristics and predictive value of blood transcriptome signature in males with autism spectrum disorders.
Kong SW, Collins CD, Shimizu-Motohashi Y, Holm IA, Campbell MG, Lee IH, Brewster SJ, Hanson E, Harris HK, Lowe KR, Saada A, Mora A, Madison K, Hundley R, Egan J, McCarthy J, Eran A, Galdzicki M, Rappaport L, Kunkel LM, Kohane IS. Kong SW, et al. PLoS One. 2012;7(12):e49475. doi: 10.1371/journal.pone.0049475. Epub 2012 Dec 5. PLoS One. 2012. PMID: 23227143 Free PMC article.
The differentially expressed genes were enriched for the neurotrophin signaling, long-term potentiation/depression, and notch signaling pathways. We developed a 55-gene prediction model, using a cross-validation strategy, on a sample cohort of 66 male ASD cases and 33 age- …
The differentially expressed genes were enriched for the neurotrophin signaling, long-term potentiation/depression, and notch signali …
Taxonomizing, sizing, and overcoming the incidentalome.
Kohane IS, Hsing M, Kong SW. Kohane IS, et al. Among authors: kong sw. Genet Med. 2012 Apr;14(4):399-404. doi: 10.1038/gim.2011.68. Epub 2012 Feb 9. Genet Med. 2012. PMID: 22323072 Free PMC article.
Of these, the first two are likely to be addressed in the near term. Conservatively, current methods deliver hundreds of false-positive incidental findings per individual. ...
Of these, the first two are likely to be addressed in the near term. Conservatively, current methods deliver hundreds of false-positi …