Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

Search Results

6 results

Filters applied: . Clear all
Page 1
Inhaling xenon ameliorates l-dopa-induced dyskinesia in experimental parkinsonism.
Baufreton J, Milekovic T, Li Q, McGuire S, Moraud EM, Porras G, Sun S, Ko WKD, Chazalon M, Morin S, Normand E, Farjot G, Milet A, Pype J, Pioli E, Courtine G, Bessière B, Bezard E. Baufreton J, et al. Among authors: ko wkd. Mov Disord. 2018 Oct;33(10):1632-1642. doi: 10.1002/mds.27404. Epub 2018 May 14. Mov Disord. 2018. PMID: 29756234 Free PMC article.
Parkinson's disease motor symptoms are treated with levodopa, but long-term treatment leads to disabling dyskinesia. Altered synaptic transmission and maladaptive plasticity of corticostriatal glutamatergic projections play a critical role in the pathophysiology of dyskine …
Parkinson's disease motor symptoms are treated with levodopa, but long-term treatment leads to disabling dyskinesia. Altered synaptic …
A preclinical study on the combined effects of repeated eltoprazine and preladenant treatment for alleviating L-DOPA-induced dyskinesia in Parkinson's disease.
Ko WKD, Li Q, Cheng LY, Morelli M, Carta M, Bezard E. Ko WKD, et al. Eur J Pharmacol. 2017 Oct 15;813:10-16. doi: 10.1016/j.ejphar.2017.07.030. Epub 2017 Jul 21. Eur J Pharmacol. 2017. PMID: 28739086
These data demonstrate the clinical utility of the modulation of the serotonergic and adenosine neurotransmitter systems with selective pharmacological agents for only acute treatment of LID. This multi-targeted approach is unsuitable as a long-term treatment regimen due t …
These data demonstrate the clinical utility of the modulation of the serotonergic and adenosine neurotransmitter systems with selective phar …
TAC1 Gene Products Regulate Pituitary Hormone Secretion and Gene Expression in Prepubertal Grass Carp Pituitary Cells.
Hu G, He M, Ko WKW, Wong AOL. Hu G, et al. Among authors: ko wkw. Endocrinology. 2017 Jun 1;158(6):1776-1797. doi: 10.1210/en.2016-1740. Endocrinology. 2017. PMID: 28323939
In carp pituitary cells, SP and NKA could trigger luteinizing hormone (LH), prolactin (PRL), and somatolactin alpha (SLalpha) secretion, with parallel rises in PRL and SLalpha transcripts. Short-term SP treatment (3 hours) induced LH release, whereas prolonged induction (2 …
In carp pituitary cells, SP and NKA could trigger luteinizing hormone (LH), prolactin (PRL), and somatolactin alpha (SLalpha) secretion, wit …
Multifunctional hydrogel coatings on the surface of neural cuff electrode for improving electrode-nerve tissue interfaces.
Heo DN, Song SJ, Kim HJ, Lee YJ, Ko WK, Lee SJ, Lee D, Park SJ, Zhang LG, Kang JY, Do SH, Lee SH, Kwon IK. Heo DN, et al. Among authors: ko wk. Acta Biomater. 2016 Jul 15;39:25-33. doi: 10.1016/j.actbio.2016.05.009. Epub 2016 May 6. Acta Biomater. 2016. PMID: 27163406
To our knowledge, our findings suggest that surface coating a soft-hydrogel along with an anti-inflammatory drug loaded MS can be a useful strategy for improving the long-term biocompatibility of electrodes....
To our knowledge, our findings suggest that surface coating a soft-hydrogel along with an anti-inflammatory drug loaded MS can be a useful s …
Antidyskinetic effect of A2A and 5HT1A/1B receptor ligands in two animal models of Parkinson's disease.
Pinna A, Ko WK, Costa G, Tronci E, Fidalgo C, Simola N, Li Q, Tabrizi MA, Bezard E, Carta M, Morelli M. Pinna A, et al. Among authors: ko wk. Mov Disord. 2016 Apr;31(4):501-11. doi: 10.1002/mds.26475. Epub 2016 Feb 12. Mov Disord. 2016. PMID: 26871939
Moreover, in the rodent striatum, induction of immediate-early gene zif-268, an index of long-term changes, was correlated with dyskinesia. RESULTS: In 6-hydroxydopamine-lesioned rats, combined administration of l-dopa (4 mg/kg) plus eltoprazine (0.6 mg/kg) plus preladenan …
Moreover, in the rodent striatum, induction of immediate-early gene zif-268, an index of long-term changes, was correlated with dyski …
M4 Muscarinic Receptor Signaling Ameliorates Striatal Plasticity Deficits in Models of L-DOPA-Induced Dyskinesia.
Shen W, Plotkin JL, Francardo V, Ko WK, Xie Z, Li Q, Fieblinger T, Wess J, Neubig RR, Lindsley CW, Conn PJ, Greengard P, Bezard E, Cenci MA, Surmeier DJ. Shen W, et al. Among authors: ko wk. Neuron. 2015 Nov 18;88(4):762-73. doi: 10.1016/j.neuron.2015.10.039. Neuron. 2015. PMID: 26590347 Free PMC article.
Our studies show that in dSPNs, endogenous cholinergic signaling through M4 muscarinic receptors (M4Rs) promoted long-term depression of corticostriatal glutamatergic synapses, by suppressing regulator of G protein signaling type 4 (RGS4) activity, and blocked D1 dopamine …
Our studies show that in dSPNs, endogenous cholinergic signaling through M4 muscarinic receptors (M4Rs) promoted long-term depression …