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A novel preclinical model of craniospinal irradiation in pediatric diffuse midline glioma demonstrates decreased metastatic disease.
Knox AJ, Van Court B, Oweida A, Barsh E, DeSisto J, Flannery P, Lemma R, Chatwin H, Vibhakar R, Dorris K, Serkova NJ, Karam SD, Gilani A, Green AL. Knox AJ, et al. Front Oncol. 2023 Apr 12;13:1105395. doi: 10.3389/fonc.2023.1105395. eCollection 2023. Front Oncol. 2023. PMID: 37124531 Free PMC article.
By expanding effective DMG treatment to the entire neuraxis, CSI has potential as a key component to combination, multimodality treatment for DMG designed to achieve long-term survival once novel therapies definitively demonstrate improved local control....
By expanding effective DMG treatment to the entire neuraxis, CSI has potential as a key component to combination, multimodality treatment fo …
Unpaid Professional Work at Home and Work-Life Interference among Employees with Care Responsibilities.
Chernyak-Hai L, Fein EC, Skinner N, Knox AJ, Brown J. Chernyak-Hai L, et al. Among authors: knox aj. J Psychol. 2021;155(3):356-374. doi: 10.1080/00223980.2021.1884825. Epub 2021 Mar 11. J Psychol. 2021. PMID: 33705255
This study examines sample of 288 working Australians from the AWALI national survey data, who care for at least one family member or friend with long-term physical or mental illness, disability, or aging-related problems. ...
This study examines sample of 288 working Australians from the AWALI national survey data, who care for at least one family member or friend …
Mammalian Ste20-like kinase 4 promotes pituitary cell proliferation and survival under hypoxia.
Xiong W, Knox AJ, Xu M, Kiseljak-Vassiliades K, Colgan SP, Brodsky KS, Kleinschmidt-Demasters BK, Lillehei KO, Wierman ME. Xiong W, et al. Among authors: knox aj. Mol Endocrinol. 2015 Mar;29(3):460-72. doi: 10.1210/me.2014-1332. Epub 2015 Feb 4. Mol Endocrinol. 2015. PMID: 25650755 Free PMC article.
To mimic the pituitary tumor microenvironment, a hypoxia model using LbetaT2 murine gonadotrope cells was created to examine the functional role of the kinase. During long-term hypoxia, MST4 expression increased colony formation in a soft agar assay and rates of cell proli …
To mimic the pituitary tumor microenvironment, a hypoxia model using LbetaT2 murine gonadotrope cells was created to examine the functional …
Modeling luminal breast cancer heterogeneity: combination therapy to suppress a hormone receptor-negative, cytokeratin 5-positive subpopulation in luminal disease.
Knox AJ, Scaling AL, Pinto MP, Bliesner BS, Haughian JM, Abdel-Hafiz HA, Horwitz KB. Knox AJ, et al. Breast Cancer Res. 2014 Aug 13;16(4):418. doi: 10.1186/s13058-014-0418-6. Breast Cancer Res. 2014. PMID: 25116921 Free PMC article.
CONCLUSIONS: We propose that response to combination endocrine/EGFR inhibitor therapies in heterogeneous Luminal cancers may improve long-term survival in patients whose primary tumors have been preselected for appropriate biomarkers, including ER, PR, CK5 and EGFR....
CONCLUSIONS: We propose that response to combination endocrine/EGFR inhibitor therapies in heterogeneous Luminal cancers may improve long- …
Interleukin-1beta, transforming growth factor-beta1, and bradykinin attenuate cyclic AMP production by human pulmonary artery smooth muscle cells in response to prostacyclin analogues and prostaglandin E2 by cyclooxygenase-2 induction and downregulation of adenylyl cyclase isoforms 1, 2, and 4.
El-Haroun H, Bradbury D, Clayton A, Knox AJ. El-Haroun H, et al. Among authors: knox aj. Circ Res. 2004 Feb 20;94(3):353-61. doi: 10.1161/01.RES.0000111801.48626.F4. Epub 2003 Dec 11. Circ Res. 2004. PMID: 14670842
In this study, we show that prolonged incubation with bradykinin (BK), interleukin-1beta (IL-1beta), and transforming growth factor-beta1 (TGF-beta1) markedly impairs cAMP accumulation in human pulmonary artery smooth muscle cells in response to short-term incubation with …
In this study, we show that prolonged incubation with bradykinin (BK), interleukin-1beta (IL-1beta), and transforming growth factor-beta1 (T …
Mechanisms involved in desensitization of particulate guanylyl cyclase in human airway smooth muscle: the role of protein kinase C.
Hamad AM, Knox AJ. Hamad AM, et al. Among authors: knox aj. Biochem Biophys Res Commun. 1999 Dec 9;266(1):152-5. doi: 10.1006/bbrc.1999.1786. Biochem Biophys Res Commun. 1999. PMID: 10581181
We recently showed that cultured human airway smooth muscle cells (HASMC) express both soluble and particulate guanylyl cyclases (GC) and that long term treatment with atrial natriuretic peptide (ANP) causes homologous desensitization of particulate GC. ...
We recently showed that cultured human airway smooth muscle cells (HASMC) express both soluble and particulate guanylyl cyclases (GC) and th …
The effect of topical benzamil and amiloride on nasal potential difference in cystic fibrosis.
Rodgers HC, Knox AJ. Rodgers HC, et al. Among authors: knox aj. Eur Respir J. 1999 Sep;14(3):693-6. doi: 10.1034/j.1399-3003.1999.14c32.x. Eur Respir J. 1999. PMID: 10543294 Free article. Clinical Trial.
The sodium channel blocker, amiloride, has been shown to reversibly correct the sodium reabsorption in CF subjects, but long term studies of amiloride have been disappointing due to its short duration of action. ...Benzamil may be a useful sodium channel blocker for the lo …
The sodium channel blocker, amiloride, has been shown to reversibly correct the sodium reabsorption in CF subjects, but long term stu …
PGE2 release by bradykinin in human airway smooth muscle cells: involvement of cyclooxygenase-2 induction.
Pang L, Knox AJ. Pang L, et al. Among authors: knox aj. Am J Physiol. 1997 Dec;273(6):L1132-40. doi: 10.1152/ajplung.1997.273.6.L1132. Am J Physiol. 1997. PMID: 9435567
In long-term (4-h) experiments, BK enhanced PGE2 release and COX activity and induced COX-2. ...Conversion of increased arachidonic acid release to PGE2 by COX-1 is mainly involved in the short-term effect, whereas B2 receptor-related COX-2 induction is important in …
In long-term (4-h) experiments, BK enhanced PGE2 release and COX activity and induced COX-2. ...Conversion of increased arachidonic a …
Rebound increase in bronchial responsiveness after treatment with inhaled terbutaline.
Vathenen AS, Knox AJ, Higgins BG, Britton JR, Tattersfield AE. Vathenen AS, et al. Among authors: knox aj. Lancet. 1988 Mar 12;1(8585):554-8. doi: 10.1016/s0140-6736(88)91352-9. Lancet. 1988. PMID: 2894492 Clinical Trial.
Subjects with mild asthma were investigated to determine the course of change in bronchial responsiveness, measured as the provocative dose (PD20) of histamine that caused a 20% fall in forced expiratory volume in 1 s after short-term and longer term treatment with …
Subjects with mild asthma were investigated to determine the course of change in bronchial responsiveness, measured as the provocative dose …
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