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Artificial Intelligence in Cardiovascular Imaging: "Unexplainable" Legal and Ethical Challenges?
Lang M, Bernier A, Knoppers BM. Lang M, et al. Among authors: knoppers bm. Can J Cardiol. 2022 Feb;38(2):225-233. doi: 10.1016/j.cjca.2021.10.009. Epub 2021 Nov 1. Can J Cardiol. 2022. PMID: 34737036 Review.
Nowhere is the influence of artificial intelligence (AI) likely to be more profoundly felt than in health care, from patient triage and diagnosis to surgery and follow-up. Over the medium-term, these effects will be more acute in the cardiovascular imaging context, in whic …
Nowhere is the influence of artificial intelligence (AI) likely to be more profoundly felt than in health care, from patient triage and diag …
Should Age-Dependent Absolute Risk Thresholds Be Used for Risk Stratification in Risk-Stratified Breast Cancer Screening?
Pashayan N, Antoniou AC, Lee A, Wolfson M, Chiquette J, Eloy L, Eisen A, Stockley TL, Nabi H, Brooks JD, Dorval M, Easton DF, Knoppers BM, Chiarelli AM, Simard J. Pashayan N, et al. Among authors: knoppers bm. J Pers Med. 2021 Sep 15;11(9):916. doi: 10.3390/jpm11090916. J Pers Med. 2021. PMID: 34575693 Free PMC article.
Absolute risk, expressed as either remaining lifetime risk or shorter-term (five- or ten-year) risk, is estimated from the age at assessment. ...
Absolute risk, expressed as either remaining lifetime risk or shorter-term (five- or ten-year) risk, is estimated from the age at ass …
A Tale of Two Capacities: Including Children and Decisionally Vulnerable Adults in Biomedical Research.
Dalpé G, Thorogood A, Knoppers BM. Dalpé G, et al. Among authors: knoppers bm. Front Genet. 2019 Apr 5;10:289. doi: 10.3389/fgene.2019.00289. eCollection 2019. Front Genet. 2019. PMID: 31024616 Free PMC article.
Our comparison between these two populations clarifies underlying ethical concepts and offers opportunities for critique. Children need protection to foster their long-term autonomy, while decisionally vulnerable adults need to be provided with support in order to exercise …
Our comparison between these two populations clarifies underlying ethical concepts and offers opportunities for critique. Children need prot …
Autologous bilayered self-assembled skin substitutes (SASSs) as permanent grafts: a case series of 14 severely burned patients indicating clinical effectiveness.
Germain L, Larouche D, Nedelec B, Perreault I, Duranceau L, Bortoluzzi P, Beaudoin Cloutier C, Genest H, Caouette-Laberge L, Dumas A, Bussière A, Boghossian E, Kanevsky J, Leclerc Y, Lee J, Nguyen MT, Bernier V, Knoppers BM, Moulin VJ, Auger FA. Germain L, et al. Among authors: knoppers bm. Eur Cell Mater. 2018 Sep 13;36:128-141. doi: 10.22203/eCM.v036a10. Eur Cell Mater. 2018. PMID: 30209799 Free article.
These results indicated that the SASS allowed the successful coverage of full-thickness burns given its high graft-take, aesthetic outcome equivalent to autografting and the promotion of long-term tissue regeneration. When skin donor sites are in short supply, SASSs could …
These results indicated that the SASS allowed the successful coverage of full-thickness burns given its high graft-take, aesthetic outcome e …
Research on Human Embryos and Reproductive Materials: Revisiting Canadian Law and Policy.
Ogbogu U, Zarzeczny A, Baltz J, Bedford P, Du J, Hyun I, Jaafar Y, Jurisicova A, Kleiderman E, Koukio Y, Knoppers BM, Leader A, Master Z, Nguyen MT, Noohi F, Ravitsky V, Toews M. Ogbogu U, et al. Among authors: knoppers bm. Healthc Policy. 2018 Feb;13(3):10-19. doi: 10.12927/hcpol.2018.25401. Healthc Policy. 2018. PMID: 29595433 Free PMC article.
With a pragmatic and principled governance approach, Canada can continue its global leadership in this field, as well as advance the long-term health and well-being of Canadians....
With a pragmatic and principled governance approach, Canada can continue its global leadership in this field, as well as advance the long- …
The Genomic Commons.
Contreras JL, Knoppers BM. Contreras JL, et al. Among authors: knoppers bm. Annu Rev Genomics Hum Genet. 2018 Aug 31;19:429-453. doi: 10.1146/annurev-genom-083117-021552. Epub 2018 Jan 25. Annu Rev Genomics Hum Genet. 2018. PMID: 29400986 Review.
Issues involving scientific priority, intellectual property, individual privacy, and informed consent, in an environment of data sets of exponentially expanding size and complexity, must be addressed in the near term. In this review, we describe the characteristics and uni …
Issues involving scientific priority, intellectual property, individual privacy, and informed consent, in an environment of data sets of exp …
Data Safe Havens in health research and healthcare.
Burton PR, Murtagh MJ, Boyd A, Williams JB, Dove ES, Wallace SE, Tassé AM, Little J, Chisholm RL, Gaye A, Hveem K, Brookes AJ, Goodwin P, Fistein J, Bobrow M, Knoppers BM. Burton PR, et al. Among authors: knoppers bm. Bioinformatics. 2015 Oct 15;31(20):3241-8. doi: 10.1093/bioinformatics/btv279. Epub 2015 Jun 25. Bioinformatics. 2015. PMID: 26112289 Free PMC article. Review.
In this context, the development of what are called 'Data Safe Havens' has been crucial. Unfortunately, the origins and evolution of the term have led to a range of different definitions being assumed by different groups. There is, however, an intuitively meaningful interp …
In this context, the development of what are called 'Data Safe Havens' has been crucial. Unfortunately, the origins and evolution of the …
International Charter of principles for sharing bio-specimens and data.
Mascalzoni D, Dove ES, Rubinstein Y, Dawkins HJ, Kole A, McCormack P, Woods S, Riess O, Schaefer F, Lochmüller H, Knoppers BM, Hansson M. Mascalzoni D, et al. Among authors: knoppers bm. Eur J Hum Genet. 2015 Jun;23(6):721-8. doi: 10.1038/ejhg.2014.197. Epub 2014 Sep 24. Eur J Hum Genet. 2015. PMID: 25248399 Free PMC article.
There is a growing international agreement on the need to provide greater access to research data and bio-specimen collections to optimize their long-term value and exploit their potential for health discovery and validation. ...
There is a growing international agreement on the need to provide greater access to research data and bio-specimen collections to optimize t …
Policy and data-intensive scientific discovery in the beginning of the 21st century.
Ozdemir V, Smith C, Bongiovanni K, Cullen D, Knoppers BM, Lowe A, Peters M, Robbins R, Stewart E, Yee G, Yu YK, Kolker E. Ozdemir V, et al. Among authors: knoppers bm. OMICS. 2011 Apr;15(4):221-5. doi: 10.1089/omi.2011.0007. OMICS. 2011. PMID: 21476845
As such, this calls for a science policy vision that is long term. We herein reflect on how best to approach to policy making at this critical inflection point when DIS applications are being diversified in agriculture, ecology, marine biology, and environmental research i …
As such, this calls for a science policy vision that is long term. We herein reflect on how best to approach to policy making at this …
Bioethics for clinicians: 14. Ethics and genetics in medicine.
Burgess MM, Laberge CM, Knoppers BM. Burgess MM, et al. Among authors: knoppers bm. CMAJ. 1998 May 19;158(10):1309-13. CMAJ. 1998. PMID: 9614824 Free PMC article. Review.
However, it is inevitable that all physicians will be involved in long-term follow-up both by monitoring for disease and by supporting the integration of genetic information into patients' lives....
However, it is inevitable that all physicians will be involved in long-term follow-up both by monitoring for disease and by supportin …