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SARS-CoV-2 infection induces a long-lived pro-inflammatory transcriptional profile.
Zhang JY, Whalley JP, Knight JC, Wicker LS, Todd JA, Ferreira RC. Zhang JY, et al. Among authors: knight jc. Genome Med. 2023 Sep 12;15(1):69. doi: 10.1186/s13073-023-01227-x. Genome Med. 2023. PMID: 37700317 Free PMC article.
BACKGROUND: The immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in COVID-19 patients has been extensively investigated. However, much less is known about the long-term effects of infection in patients and how it could affect the im …
BACKGROUND: The immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in COVID-19 patients has been exte …
Divergent trajectories of antiviral memory after SARS-CoV-2 infection.
Tomic A, Skelly DT, Ogbe A, O'Connor D, Pace M, Adland E, Alexander F, Ali M, Allott K, Azim Ansari M, Belij-Rammerstorfer S, Bibi S, Blackwell L, Brown A, Brown H, Cavell B, Clutterbuck EA, de Silva T, Eyre D, Lumley S, Flaxman A, Grist J, Hackstein CP, Halkerston R, Harding AC, Hill J, James T, Jay C, Johnson SA, Kronsteiner B, Lie Y, Linder A, Longet S, Marinou S, Matthews PC, Mellors J, Petropoulos C, Rongkard P, Sedik C, Silva-Reyes L, Smith H, Stockdale L, Taylor S, Thomas S, Tipoe T, Turtle L, Vieira VA, Wrin T; OPTIC Clinical Group; PITCH Study Group; C-MORE Group; Pollard AJ, Lambe T, Conlon CP, Jeffery K, Travis S, Goulder P, Frater J, Mentzer AJ, Stafford L, Carroll MW, James WS, Klenerman P, Barnes E, Dold C, Dunachie SJ. Tomic A, et al. Nat Commun. 2022 Mar 10;13(1):1251. doi: 10.1038/s41467-022-28898-1. Nat Commun. 2022. PMID: 35273178 Free PMC article.
We identify a subgroup of participants with higher antibody responses and interferon-gamma ELISpot T cell responses, and a robust trajectory for longer term immunity associates with higher levels of neutralising antibodies against the infecting (Victoria) strain and also a …
We identify a subgroup of participants with higher antibody responses and interferon-gamma ELISpot T cell responses, and a robust trajectory …
Peripheral CD8+ T cell characteristics associated with durable responses to immune checkpoint blockade in patients with metastatic melanoma.
Fairfax BP, Taylor CA, Watson RA, Nassiri I, Danielli S, Fang H, Mahé EA, Cooper R, Woodcock V, Traill Z, Al-Mossawi MH, Knight JC, Klenerman P, Payne M, Middleton MR. Fairfax BP, et al. Among authors: knight jc. Nat Med. 2020 Feb;26(2):193-199. doi: 10.1038/s41591-019-0734-6. Epub 2020 Feb 10. Nat Med. 2020. PMID: 32042196 Free PMC article.
The 6-month clinical response to ICB in patients with MM is associated with the large CD8(+) T cell clone count 21 d after treatment and agnostic to clonal specificity, suggesting that post-ICB peripheral CD8(+) clonality can provide information regarding long-term treatme …
The 6-month clinical response to ICB in patients with MM is associated with the large CD8(+) T cell clone count 21 d after treatment and agn …
Genomic Response to Vitamin D Supplementation in the Setting of a Randomized, Placebo-Controlled Trial.
Berlanga-Taylor AJ, Plant K, Dahl A, Lau E, Hill M, Sims D, Heger A, Emberson J, Armitage J, Clarke R, Knight JC. Berlanga-Taylor AJ, et al. Among authors: knight jc. EBioMedicine. 2018 May;31:133-142. doi: 10.1016/j.ebiom.2018.04.010. Epub 2018 Apr 10. EBioMedicine. 2018. PMID: 29685792 Free PMC article. Clinical Trial.
Although this study was limited to mostly Caucasian individuals aged over 65 years, the results differ from many previous studies and do not support a strong effect of vitamin D on long-term transcriptomic changes in blood or on plasma cytokine levels. ...
Although this study was limited to mostly Caucasian individuals aged over 65 years, the results differ from many previous studies and do not …
Associations of HLA alleles with specific language impairment.
Nudel R, Simpson NH, Baird G, O'Hare A, Conti-Ramsden G, Bolton PF, Hennessy ER; SLI Consortium; Monaco AP, Knight JC, Winney B, Fisher SE, Newbury DF. Nudel R, et al. Among authors: knight jc. J Neurodev Disord. 2014 Jan 17;6(1):1. doi: 10.1186/1866-1955-6-1. J Neurodev Disord. 2014. PMID: 24433325 Free PMC article.
RESULTS: Quantitative association analyses of imputed HLA types suggested a role for the HLA-A locus in susceptibility to SLI. HLA-A A1 was associated with a measure of short-term memory (P = 0.004) and A3 with expressive language ability (P = 0.006). ...
RESULTS: Quantitative association analyses of imputed HLA types suggested a role for the HLA-A locus in susceptibility to SLI. HLA-A A1 was …
Compact, stable and efficient all-fibre gas cells using hollow-core photonic crystal fibres.
Benabid F, Couny F, Knight JC, Birks TA, Russell PS. Benabid F, et al. Among authors: knight jc. Nature. 2005 Mar 24;434(7032):488-91. doi: 10.1038/nature03349. Nature. 2005. PMID: 15791251
Our structures are based on gas-filled hollow-core photonic crystal fibres, in which we have recently demonstrated substantially enhanced stimulated Raman scattering, and which exhibit high performance, excellent long-term pressure stability and ease of use. To illustrate …
Our structures are based on gas-filled hollow-core photonic crystal fibres, in which we have recently demonstrated substantially enhanced st …