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Impact of SARS-CoV-2 Infection on the Association Between Laboratory Tests and Severe Outcomes Among Hospitalized Children.
Xie J, Kuppermann N, Florin TA, Tancredi DJ, Funk AL, Kim K, Salvadori MI, Yock-Corrales A, Shah NP, Breslin KA, Chaudhari PP, Bergmann KR, Ahmad FA, Nebhrajani JR, Mintegi S, Gangoiti I, Plint AC, Avva UR, Gardiner MA, Malley R, Finkelstein Y, Dalziel SR, Bhatt M, Kannikeswaran N, Caperell K, Campos C, Sabhaney VJ, Chong SL, Lunoe MM, Rogers AJ, Becker SM, Borland ML, Sartori LF, Pavlicich V, Rino PB, Morrison AK, Neuman MI, Poonai N, Simon NE, Kam AJ, Kwok MY, Morris CR, Palumbo L, Ambroggio L, Navanandan N, Eckerle M, Klassen TP, Payne DC, Cherry JC, Waseem M, Dixon AC, Ferre IB, Freedman SB. Xie J, et al. Among authors: klassen tp. Open Forum Infect Dis. 2023 Oct 3;10(10):ofad485. doi: 10.1093/ofid/ofad485. eCollection 2023 Oct. Open Forum Infect Dis. 2023. PMID: 37869403 Free PMC article.
In regression analysis, we found that among SARS-CoV-2-positive children, procalcitonin 0.5 ng/mL (adjusted odds ratio [aOR], 9.14; 95% CI, 2.90-28.80), ferritin >500 ng/mL (aOR, 7.95; 95% CI, 1.89-33.44), D-dimer 1500 ng/mL (aOR, 4.57; 95% CI, 1.12-18.68), serum glucose 120 m …
In regression analysis, we found that among SARS-CoV-2-positive children, procalcitonin 0.5 ng/mL (adjusted odds ratio [aOR], 9.14; 95% CI, …
Nonmedical Opioid Use After Short-term Therapeutic Exposure in Children: A Systematic Review.
Ahrari M, Ali S, Hartling L, Dong K, Drendel AL, Klassen TP, Schreiner K, Dyson MP. Ahrari M, et al. Among authors: klassen tp. Pediatrics. 2021 Dec 1;148(6):e2021051927. doi: 10.1542/peds.2021-051927. Pediatrics. 2021. PMID: 34816280
OBJECTIVE: To synthesize research examining the association between short-term therapeutic opioid exposure and future nonmedical opioid use or opioid use disorder and associated risk factors. ...Studies were included if: they were published in English or French, participan …
OBJECTIVE: To synthesize research examining the association between short-term therapeutic opioid exposure and future nonmedical opio …
Prospective cohort study of children with suspected SARS-CoV-2 infection presenting to paediatric emergency departments: a Paediatric Emergency Research Networks (PERN) Study Protocol.
Funk AL, Florin TA, Dalziel SR, Mintegi S, Salvadori MI, Tancredi DJ, Neuman MI, Payne DC, Plint AC, Klassen TP, Malley R, Ambroggio L, Kim K, Kuppermann N, Freedman SB. Funk AL, et al. Among authors: klassen tp. BMJ Open. 2021 Jan 15;11(1):e042121. doi: 10.1136/bmjopen-2020-042121. BMJ Open. 2021. PMID: 33452195 Free PMC article.
For all children, follow-up at 14 and 90 days will collect information on further medical care received, and long-term sequelae, respectively. Statistical models will be designed to identify risk factors for infection and severe outcomes. ...
For all children, follow-up at 14 and 90 days will collect information on further medical care received, and long-term sequelae, resp …
Safety of corticosteroids in young children with acute respiratory conditions: a systematic review and meta-analysis.
Fernandes RM, Wingert A, Vandermeer B, Featherstone R, Ali S, Plint AC, Stang AS, Rowe BH, Johnson DW, Allain D, Klassen TP, Hartling L. Fernandes RM, et al. Among authors: klassen tp. BMJ Open. 2019 Aug 1;9(8):e028511. doi: 10.1136/bmjopen-2018-028511. BMJ Open. 2019. PMID: 31375615 Free PMC article.
OBJECTIVE: Adverse events (AEs) associated with short-term corticosteroid use for respiratory conditions in young children. ...No significant differences were found comparing systemic or inhaled corticosteroid with placebo, or between corticosteroids, for other AEs; CIs ar …
OBJECTIVE: Adverse events (AEs) associated with short-term corticosteroid use for respiratory conditions in young children. ...No sig …
Nebulised hypertonic saline solution for acute bronchiolitis in infants.
Zhang L, Mendoza-Sassi RA, Wainwright C, Klassen TP. Zhang L, et al. Among authors: klassen tp. Cochrane Database Syst Rev. 2013 Jul 31;(7):CD006458. doi: 10.1002/14651858.CD006458.pub3. Cochrane Database Syst Rev. 2013. PMID: 23900970 Updated. Review.
Four emergency department-based trials did not show any significant short-term effects (30 to 120 minutes) of up to three doses of nebulised 3% saline in improving clinical score and oxygen saturation. ...
Four emergency department-based trials did not show any significant short-term effects (30 to 120 minutes) of up to three doses of ne …
Glucocorticoids for acute viral bronchiolitis in infants and young children.
Fernandes RM, Bialy LM, Vandermeer B, Tjosvold L, Plint AC, Patel H, Johnson DW, Klassen TP, Hartling L. Fernandes RM, et al. Among authors: klassen tp. Cochrane Database Syst Rev. 2013 Jun 4;2013(6):CD004878. doi: 10.1002/14651858.CD004878.pub4. Cochrane Database Syst Rev. 2013. PMID: 23733383 Free PMC article. Review.
SELECTION CRITERIA: Randomised controlled trials (RCTs) comparing short-term systemic or inhaled glucocorticoids versus placebo or another intervention in children under 24 months with acute bronchiolitis (first episode with wheezing). ...Unadjusted results from a large fa …
SELECTION CRITERIA: Randomised controlled trials (RCTs) comparing short-term systemic or inhaled glucocorticoids versus placebo or an …
Epinephrine for bronchiolitis.
Hartling L, Bialy LM, Vandermeer B, Tjosvold L, Johnson DW, Plint AC, Klassen TP, Patel H, Fernandes RM. Hartling L, et al. Among authors: klassen tp. Cochrane Database Syst Rev. 2011 Jun 15;(6):CD003123. doi: 10.1002/14651858.CD003123.pub3. Cochrane Database Syst Rev. 2011. PMID: 21678340 Review.
AUTHORS' CONCLUSIONS: This review demonstrates the superiority of epinephrine compared to placebo for short-term outcomes for outpatients, particularly in the first 24 hours of care. ...
AUTHORS' CONCLUSIONS: This review demonstrates the superiority of epinephrine compared to placebo for short-term outcomes for outpati …
Glucocorticoids for acute viral bronchiolitis in infants and young children.
Fernandes RM, Bialy LM, Vandermeer B, Tjosvold L, Plint AC, Patel H, Johnson DW, Klassen TP, Hartling L. Fernandes RM, et al. Among authors: klassen tp. Cochrane Database Syst Rev. 2010 Oct 6;(10):CD004878. doi: 10.1002/14651858.CD004878.pub3. Cochrane Database Syst Rev. 2010. PMID: 20927740 Updated. Review.

SELECTION CRITERIA: Randomised controlled trials (RCTs) comparing short-term systemic or inhaled glucocorticoids versus placebo or another intervention in children < 24 months with acute bronchiolitis (first episode with wheezing). ...Unadjusted results from a large fac

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SELECTION CRITERIA: Randomised controlled trials (RCTs) comparing short-term systemic or inhaled glucocorticoids versus placebo or an …
Short-course antibiotics for acute otitis media.
Kozyrskyj A, Klassen TP, Moffatt M, Harvey K. Kozyrskyj A, et al. Among authors: klassen tp. Cochrane Database Syst Rev. 2010 Sep 8;2010(9):CD001095. doi: 10.1002/14651858.CD001095.pub2. Cochrane Database Syst Rev. 2010. PMID: 20824827 Free PMC article. Review.
AUTHORS' CONCLUSIONS: Clinicians need to evaluate whether the minimal short-term benefit from longer treatment of antibiotics is worth exposing children to a longer course of antibiotics....
AUTHORS' CONCLUSIONS: Clinicians need to evaluate whether the minimal short-term benefit from longer treatment of antibiotics is wort …
Exercise interventions for upper-limb dysfunction due to breast cancer treatment.
McNeely ML, Campbell K, Ospina M, Rowe BH, Dabbs K, Klassen TP, Mackey J, Courneya K. McNeely ML, et al. Among authors: klassen tp. Cochrane Database Syst Rev. 2010 Jun 16;(6):CD005211. doi: 10.1002/14651858.CD005211.pub2. Cochrane Database Syst Rev. 2010. PMID: 20556760 Review.
Implementing early exercise was more effective than delayed exercise in the short term recovery of shoulder flexion ROM (Weighted Mean Difference (WMD): 10.6 degrees; 95% Confidence Interval (CI): 4.51 to 16.6); however, early exercise also resulted in a statistically sign …
Implementing early exercise was more effective than delayed exercise in the short term recovery of shoulder flexion ROM (Weighted Mea …
24 results