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Effect of statin therapy on muscle symptoms: an individual participant data meta-analysis of large-scale, randomised, double-blind trials.
Cholesterol Treatment Trialists' Collaboration. Cholesterol Treatment Trialists' Collaboration. Lancet. 2022 Sep 10;400(10355):832-845. doi: 10.1016/S0140-6736(22)01545-8. Epub 2022 Aug 29. Lancet. 2022. PMID: 36049498 Free PMC article.
We aimed to address these through an individual participant data meta-analysis of all recorded adverse muscle events in large, long-term, randomised, double-blind trials of statin therapy. METHODS: Randomised trials of statin therapy were eligible if they aimed to recruit …
We aimed to address these through an individual participant data meta-analysis of all recorded adverse muscle events in large, long-term …
Long-term cardiovascular risks and the impact of statin treatment on socioeconomic inequalities: a microsimulation model.
Wu R, Williams C, Zhou J, Schlackow I, Emberson J, Reith C, Keech A, Robson J, Armitage J, Gray A, Simes J, Baigent C, Mihaylova B; CTT Collaboration secretariat; Armitage J, Baigent C, Barnes E, Blackwell L, Collins R, Davies K, Emberson J, Fulcher J, Halls H, Herrington WG, Holland L, Keech A, Kirby A, Mihaylova B, O'Connell R, Preiss D, Reith C, Simes J, Wilson K; CTT Collaboration trialists: A to Z trial (phase Z); Blazing M, Braunwald E, Lemos J, Murphy S, Pedersen TR, Pfeffer M, White H, Wiviott S; AFCAPS/TEXCAPS (AirForce/Texas Coronary Atherosclerosis Prevention Study); Clearfield M, Downs JR, Gotto A Jr, Weis S; ALERT (Assessment of Lescol in Renal Transplantation); Fellström B, Holdaas H, Jardine A, Pedersen TR; ALLHAT (Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial); Gordon D, Davis B, Furberg C, Grimm R, Pressel S, Probstfield JL, Rahman M, Simpson L; ALLIANCE (Aggressive Lipid-Lowering Initiation Abates New Cardiac Events); Koren M; ASCOT (Anglo-Scandinavian Cardiac Outcomes Trial); Dahlöf B, Gupta A, Poulter N, Sever P, Wedel H; ASPEN (Atorvastatin Study for the Prevention of Coronary Heart Disease Endpoints in Non-Insulin Dependen… See abstract for full author list ➔ Wu R, et al. Among authors: kirby a. Br J Gen Pract. 2024 Feb 19;74(740):e189-98. doi: 10.3399/BJGP.2023.0198. Online ahead of print. Br J Gen Pract. 2024. PMID: 38373851 Free PMC article.
CONCLUSION: The study demonstrated the potential of guideline-recommended statin treatment to reduce socioeconomic inequalities. This CVD model is a novel resource for individualised long-term projections of health outcomes of CVD treatments....
CONCLUSION: The study demonstrated the potential of guideline-recommended statin treatment to reduce socioeconomic inequalities. This CVD mo …
Effect of a Hybrid Closed-Loop System on Glycemic and Psychosocial Outcomes in Children and Adolescents With Type 1 Diabetes: A Randomized Clinical Trial.
Abraham MB, de Bock M, Smith GJ, Dart J, Fairchild JM, King BR, Ambler GR, Cameron FJ, McAuley SA, Keech AC, Jenkins A, Davis EA, O'Neal DN, Jones TW; Australian Juvenile Diabetes Research Fund Closed-Loop Research group. Abraham MB, et al. JAMA Pediatr. 2021 Dec 1;175(12):1227-1235. doi: 10.1001/jamapediatrics.2021.3965. JAMA Pediatr. 2021. PMID: 34633418 Free PMC article. Clinical Trial.
IMPORTANCE: Hybrid closed-loop (HCL) therapy has improved glycemic control in children and adolescents with type 1 diabetes; however, the efficacy of HCL on glycemic and psychosocial outcomes has not yet been established in a long-term randomized clinical trial. OBJECTIVE: …
IMPORTANCE: Hybrid closed-loop (HCL) therapy has improved glycemic control in children and adolescents with type 1 diabetes; however, the ef …
Effects of delayed versus immediate umbilical cord clamping in reducing death or major disability at 2 years corrected age among very preterm infants (APTS): a multicentre, randomised clinical trial.
Robledo KP, Tarnow-Mordi WO, Rieger I, Suresh P, Martin A, Yeung C, Ghadge A, Liley HG, Osborn D, Morris J, Hague W, Kluckow M, Lui K, Soll R, Cruz M, Keech A, Kirby A, Simes J; APTS Childhood Follow-up Study collaborators. Robledo KP, et al. Among authors: kirby a. Lancet Child Adolesc Health. 2022 Mar;6(3):150-157. doi: 10.1016/S2352-4642(21)00373-4. Epub 2021 Dec 8. Lancet Child Adolesc Health. 2022. PMID: 34895510 Clinical Trial.
We assessed whether delayed clamping of the umbilical cord reduces mortality or major disability at 2 years in the APTS Childhood Follow Up Study. METHODS: In this long-term follow-up analysis of the multicentre, randomised APTS trial in 25 centres in seven countries, infa …
We assessed whether delayed clamping of the umbilical cord reduces mortality or major disability at 2 years in the APTS Childhood Follow Up …
Evaluation and management of vaginoplasty complications.
Amies Oelschlager AM, Kirby A, Breech L. Amies Oelschlager AM, et al. Among authors: kirby a. Curr Opin Obstet Gynecol. 2017 Oct;29(5):316-321. doi: 10.1097/GCO.0000000000000391. Curr Opin Obstet Gynecol. 2017. PMID: 28696998 Review.
All vaginoplasty techniques carry significant risk of both immediate and long-term complications. RECENT FINDINGS: The purpose of this study is to provide a review of the evaluation and management of the neovagina, addressing management of human papilloma virus infections …
All vaginoplasty techniques carry significant risk of both immediate and long-term complications. RECENT FINDINGS: The purpose of thi …
Bloody Stools in a 3-Day-Old Term Infant.
Bray-Aschenbrenner A, Feldenberg LR, Kirby A, Fitzpatrick CM, Josephsen JB. Bray-Aschenbrenner A, et al. Among authors: kirby a. Pediatrics. 2017 Sep;140(3):e20170073. doi: 10.1542/peds.2017-0073. Epub 2017 Aug 10. Pediatrics. 2017. PMID: 28798146
A 3-day-old term, male infant presented to the emergency department for evaluation of bloody stools. ...Our multidisciplinary panel will discuss the assessment of bloody stools in the term newborn, evaluation of electrolyte abnormalities, the diagnosis, and patient …
A 3-day-old term, male infant presented to the emergency department for evaluation of bloody stools. ...Our multidisciplinary panel w …
Diagnosing developmental coordination disorders.
Kirby A, Sugden D, Purcell C. Kirby A, et al. Arch Dis Child. 2014 Mar;99(3):292-6. doi: 10.1136/archdischild-2012-303569. Epub 2013 Nov 19. Arch Dis Child. 2014. PMID: 24255567 Review.
There is increasing evidence of the continuing impact into adulthood and the long-term negative effects on relationships and employment. There is a need for early identification and intervention to limit the likelihood of these secondary consequences from emerging. ...
There is increasing evidence of the continuing impact into adulthood and the long-term negative effects on relationships and employme …
One versus three weeks hypofractionated whole breast radiotherapy for early breast cancer treatment: the FAST-Forward phase III RCT.
Brunt AM, Haviland JS, Wheatley DA, Sydenham MA, Bloomfield DJ, Chan C, Cleator S, Coles CE, Donovan E, Fleming H, Glynn D, Goodman A, Griffin S, Hopwood P, Kirby AM, Kirwan CC, Nabi Z, Patel J, Sawyer E, Somaiah N, Syndikus I, Venables K, Yarnold JR, Bliss JM; FAST-Forward Trial Management Group. Brunt AM, et al. Among authors: kirby am. Health Technol Assess. 2023 Nov;27(25):1-176. doi: 10.3310/WWBF1044. Health Technol Assess. 2023. PMID: 37991196 Free PMC article. Clinical Trial.
Patients diagnosed with early breast cancer are often recommended to have radiotherapy after surgery because research has shown that it lowers the risk of the cancer returning. However, it may cause some short- and long-term side effects. Previous clinical trials showed th …
Patients diagnosed with early breast cancer are often recommended to have radiotherapy after surgery because research has shown that it lowe …
Proton Beam Therapy for Early Breast Cancer: A Systematic Review and Meta-analysis of Clinical Outcomes.
Holt F, Probert J, Darby SC, Haviland JS, Coles CE, Kirby AM, Liu Z, Dodwell D, Ntentas G, Duane F, Taylor C. Holt F, et al. Among authors: kirby am. Int J Radiat Oncol Biol Phys. 2023 Nov 15;117(4):869-882. doi: 10.1016/j.ijrobp.2023.02.023. Epub 2023 Mar 2. Int J Radiat Oncol Biol Phys. 2023. PMID: 36868521 Free PMC article.
Ongoing randomized trials will provide information on its longer-term safety compared with standard photon radiation therapy....
Ongoing randomized trials will provide information on its longer-term safety compared with standard photon radiation therapy....
Cardiac Side-effects From Breast Cancer Radiotherapy.
Taylor CW, Kirby AM. Taylor CW, et al. Among authors: kirby am. Clin Oncol (R Coll Radiol). 2015 Nov;27(11):621-9. doi: 10.1016/j.clon.2015.06.007. Epub 2015 Jun 28. Clin Oncol (R Coll Radiol). 2015. PMID: 26133462 Review.
79 results