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Hematopoietic stem cell function requires 12/15-lipoxygenase-dependent fatty acid metabolism.
Kinder M, Wei C, Shelat SG, Kundu M, Zhao L, Blair IA, Puré E. Kinder M, et al. Blood. 2010 Jun 17;115(24):5012-22. doi: 10.1182/blood-2009-09-243139. Epub 2010 Mar 31. Blood. 2010. PMID: 20357242 Free PMC article.
Furthermore, we demonstrate that 12/15-LOX is required for the maintenance of long-term HSC quiescence and number. The defect in HSCs is cell-autonomous and associated with a selective reduction in 12/15-LOX-mediated generation of bioactive lipid mediators and reactive oxy …
Furthermore, we demonstrate that 12/15-LOX is required for the maintenance of long-term HSC quiescence and number. The defect in HSCs …