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Care needs of caregivers of the elderly with early-stage dementia.
Kimura H, Koga K, Nishio M. Kimura H, et al. J Rural Med. 2024 Apr;19(2):57-65. doi: 10.2185/jrm.2023-023. Epub 2024 Apr 12. J Rural Med. 2024. PMID: 38655223 Free PMC article.
They were trying to balance caregiving with work and housekeeping and reduce the stress and burden of long-term care. Older caregivers were confused about caregiving and wanted someone to talk about their situations. ...
They were trying to balance caregiving with work and housekeeping and reduce the stress and burden of long-term care. Older caregiver …
Anxiety, depression and quality of life in patients with head and neck cancer undergoing laryngectomy: A long-term prospective evaluation.
Mukoyama N, Nishio N, Kimura H, Tokura T, Kishi S, Ogasawara K, Tsuzuki H, Yokoi S, Wada A, Shigeyama M, Ozaki N, Fujimoto Y, Sone M. Mukoyama N, et al. Among authors: kimura h. Int J Lang Commun Disord. 2024 Apr 22. doi: 10.1111/1460-6984.13036. Online ahead of print. Int J Lang Commun Disord. 2024. PMID: 38647077
What are the potential or actual clinical implications of this work? Our long-term observational study showed that the scores for anxiety, depression and QoL in laryngectomised patients improved at 1 year after surgery and were maintained for up to 5 years. Clinicians shou …
What are the potential or actual clinical implications of this work? Our long-term observational study showed that the scores for anx …
Recurrent cementoblastoma with multifocal growth and cellular atypia: a case report.
Oya K, Takeshita A, Wakamori K, Song M, Kimura H, Hirose K, Shimamoto H, Sato S, Matsunaga K, Uzawa N, Toyosawa S. Oya K, et al. Among authors: kimura h. Diagn Pathol. 2024 Apr 8;19(1):57. doi: 10.1186/s13000-024-01479-0. Diagn Pathol. 2024. PMID: 38589906 Free PMC article.
CONCLUSIONS: Pathological analyses of this case suggested that the recurrent event in the cementoblastoma altered its growth pattern and tumor cell shape. Moreover, in the case of enucleation surgery, long-term follow-up is important because there is some recurrent risk of …
CONCLUSIONS: Pathological analyses of this case suggested that the recurrent event in the cementoblastoma altered its growth pattern and tum …
Clinical course of COPD patients with exercise-induced elevation of pulmonary artery pressure or less severe pulmonary hypertension presenting with respiratory symptoms and the impact of bosentan intervention-prospective, single-center, randomized, parallel-group study.
Kashiwada T, Tanaka Y, Tanaka T, Okano T, Saito Y, Seike M, Hino M, Kimura H, Gemma A. Kashiwada T, et al. Among authors: kimura h. BMC Pulm Med. 2024 Feb 17;24(1):90. doi: 10.1186/s12890-024-02895-0. BMC Pulm Med. 2024. PMID: 38368315 Free PMC article. Clinical Trial.
BACKGROUND: The data on bosentan were lacking for the treatment of exercise-induced elevation of pulmonary artery pressure (eePAP) or less severe PH in COPD. This study was conducted to investigate long-term efficacy and safety of bosentan for the treatment of eePAP or les …
BACKGROUND: The data on bosentan were lacking for the treatment of exercise-induced elevation of pulmonary artery pressure (eePAP) or less s …
Host-to-graft propagation of inoculated α-synuclein into transplanted human induced pluripotent stem cell-derived midbrain dopaminergic neurons.
Gima S, Oe K, Nishimura K, Ohgita T, Ito H, Kimura H, Saito H, Takata K. Gima S, et al. Among authors: kimura h. Regen Ther. 2024 Jan 6;25:229-237. doi: 10.1016/j.reth.2023.12.019. eCollection 2024 Mar. Regen Ther. 2024. PMID: 38283940 Free PMC article.
Postmortem studies of patients with fetal grafts revealed that alpha-synuclein(+) Lewy body (LB)-like inclusions emerged in long-term transplantation and might worsen clinical outcomes even if the grafts survived and innervated in the recipients. ...
Postmortem studies of patients with fetal grafts revealed that alpha-synuclein(+) Lewy body (LB)-like inclusions emerged in long-term …
Hydrogen Sulfide (H2S)/Polysulfides (H2Sn) Signalling and TRPA1 Channels Modification on Sulfur Metabolism.
Kimura H. Kimura H. Biomolecules. 2024 Jan 19;14(1):129. doi: 10.3390/biom14010129. Biomolecules. 2024. PMID: 38275758 Free PMC article. Review.
Recently, we found that H(2)S/H(2)S(2) regulate the release of neurotransmitters, such as GABA, glutamate, and D-serine, a co-agonist of N-methyl-D-aspartate (NMDA) receptors. H(2)S facilitates the induction of hippocampal long-term potentiation, a synaptic model of memory …
Recently, we found that H(2)S/H(2)S(2) regulate the release of neurotransmitters, such as GABA, glutamate, and D-serine, a co-agonist of N-m …
Exacerbation of Thymoma-Associated Myasthenia Gravis Following Efgartigimod Treatment Related to Anti-acetylcholine Receptor Antibody Overshoot: A Report of Two Cases.
Kawama K, Warabi Y, Bokuda K, Kimura H, Takahashi K. Kawama K, et al. Among authors: kimura h. Cureus. 2023 Dec 17;15(12):e50692. doi: 10.7759/cureus.50692. eCollection 2023 Dec. Cureus. 2023. PMID: 38229781 Free PMC article.
Recently, efgartigimod, a human IgG1 antibody Fc fragment engineered to reduce the pathogenic IgG autoantibody level, was developed as a treatment for MG. However, the long-term effects of the treatment are still unclear. The present report describes two novel cases of thy …
Recently, efgartigimod, a human IgG1 antibody Fc fragment engineered to reduce the pathogenic IgG autoantibody level, was developed as a tre …
Live two-way video versus face-to-face treatment for depression, anxiety, and obsessive-compulsive disorder: A 24-week randomized controlled trial.
Kishimoto T, Kinoshita S, Kitazawa M, Hishimoto A, Asami T, Suda A, Bun S, Kikuchi T, Sado M, Takamiya A, Mimura M, Sato Y, Takemura R, Nagashima K, Nakamae T, Abe Y, Kanazawa T, Kawabata Y, Tomita H, Abe K, Hongo S, Kimura H, Sato A, Kida H, Sakuma K, Funayama M, Sugiyama N, Hino K, Amagai T, Takamiya M, Kodama H, Goto K, Fujiwara S, Kaiya H, Nagao K; J‐PROTECT collaborators. Kishimoto T, et al. Among authors: kimura h. Psychiatry Clin Neurosci. 2024 Apr;78(4):220-228. doi: 10.1111/pcn.13618. Epub 2023 Dec 15. Psychiatry Clin Neurosci. 2024. PMID: 38102849 Clinical Trial.
Here, we conducted the first large-scale pragmatic, randomized controlled trial to determine the effectiveness of long-term treatment for multiple psychiatric disorders via two-way video using smartphones and other devices, which are currently the primary means of telecomm …
Here, we conducted the first large-scale pragmatic, randomized controlled trial to determine the effectiveness of long-term treatment …
Development of a contacting transwell co-culture system for the in vitro propagation of primary central nervous system lymphoma.
Nishi M, Tateishi K, Sundararaj JS, Ino Y, Nakai Y, Hatayama Y, Yamaoka Y, Mihana Y, Miyakawa K, Kimura H, Kimura Y, Yamamoto T, Ryo A. Nishi M, et al. Among authors: kimura h. Front Cell Dev Biol. 2023 Nov 27;11:1275519. doi: 10.3389/fcell.2023.1275519. eCollection 2023. Front Cell Dev Biol. 2023. PMID: 38089883 Free PMC article.
We further delineated the underlying molecular mechanisms and found that the HGF-c-Met axis may be involved in the long-term in vitro culture of PCNSL cells. Moreover, the peptidylprolyl isomerase Pin1 was found to play a key role in PCNSL cell survival and it sustained pr …
We further delineated the underlying molecular mechanisms and found that the HGF-c-Met axis may be involved in the long-term in vitro …
Role of Polyunsaturated Fat in Modifying Cardiovascular Risk Associated With Family History of Cardiovascular Disease: Pooled De Novo Results From 15 Observational Studies.
Laguzzi F, Åkesson A, Marklund M, Qian F, Gigante B, Bartz TM, Bassett JK, Birukov A, Campos H, Hirakawa Y, Imamura F, Jäger S, Lankinen M, Murphy RA, Senn M, Tanaka T, Tintle N, Virtanen JK, Yamagishi K, Allison M, Brouwer IA, De Faire U, Eiriksdottir G, Ferrucci L, Forouhi NG, Geleijnse JM, Hodge AM, Kimura H, Laakso M, Risérus U, van Westing AC, Bandinelli S, Baylin A, Giles GG, Gudnason V, Iso H, Lemaitre RN, Ninomiya T, Post WS, Psaty BM, Salonen JT, Schulze MB, Tsai MY, Uusitupa M, Wareham NJ, Oh SW, Wood AC, Harris WS, Siscovick D, Mozaffarian D, Leander K; Fatty Acids and Outcomes Research Consortium (FORCE). Laguzzi F, et al. Among authors: kimura h. Circulation. 2024 Jan 23;149(4):305-316. doi: 10.1161/CIRCULATIONAHA.123.065530. Epub 2023 Dec 4. Circulation. 2024. PMID: 38047387 Free PMC article.
We assessed interactions between biomarkers of low PUFA intake and a family history in relation to long-term CVD risk in a large consortium. METHODS: Blood and tissue PUFA data from 40 885 CVD-free adults were assessed. ...RESULTS: After multivariable adjustments, a signif …
We assessed interactions between biomarkers of low PUFA intake and a family history in relation to long-term CVD risk in a large cons …
260 results