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Long-term pulmonary outcome of children with congenital diaphragmatic hernia: functional lung MRI using matrix-pencil decomposition enables side-specific assessment of lung function.
Streibel C, Willers CC, Bauman G, Pusterla O, Bieri O, Curdy M, Horn M, Casaulta C, Berger S, Dekany GM, Kieninger E, Bartenstein A, Latzin P. Streibel C, et al. Among authors: kieninger e. Eur Radiol. 2023 Nov 20. doi: 10.1007/s00330-023-10395-8. Online ahead of print. Eur Radiol. 2023. PMID: 37982833 Free article.
We aimed to assess the overall and side-specific pulmonary long-term outcomes of patients with CDH using lung function tests and MP-MRI. ...
We aimed to assess the overall and side-specific pulmonary long-term outcomes of patients with CDH using lung function tests and MP-M …
Predictors of asthma control differ from predictors of asthma attacks in children: The Swiss Paediatric Airway Cohort.
Ardura-Garcia C, Mallet MC, Berger DO, Hoyler K, Jochmann A, Kuhn A, Moeller A, Regamey N, Singer F, Pedersen ESL, Kuehni CE; SPAC Study Team. Ardura-Garcia C, et al. Clin Exp Allergy. 2023 Nov;53(11):1177-1186. doi: 10.1111/cea.14390. Epub 2023 Sep 2. Clin Exp Allergy. 2023. PMID: 37658735 Free article.
Lung function, exhaled nitric oxide (FeNO) and allergic sensitization at baseline were not associated with control or attacks. CONCLUSION: Children at risk of long-term suboptimal asthma control differ from those at risk of attacks. ...
Lung function, exhaled nitric oxide (FeNO) and allergic sensitization at baseline were not associated with control or attacks. CONCLUSION: C …
Variability of clinically measured lung clearance index in children with cystic fibrosis.
Frauchiger BS, Ramsey KA, Usemann J, Kieninger E, Casaulta C, Sirtes D, Yammine S, Spycher B, Moeller A, Latzin P. Frauchiger BS, et al. Among authors: kieninger e. Pediatr Pulmonol. 2023 Jan;58(1):197-205. doi: 10.1002/ppul.26180. Epub 2022 Nov 2. Pediatr Pulmonol. 2023. PMID: 36251441
RATIONALE: The lung clearance index (LCI) is increasingly being used in the clinical surveillance of patients with cystic fibrosis (CF). However, there are limited data on long-term variability and physiologically relevant changes in LCI during routine clinical surveillanc …
RATIONALE: The lung clearance index (LCI) is increasingly being used in the clinical surveillance of patients with cystic fibrosis (CF). How …
Short-Term Effects of Elexacaftor/Tezacaftor/Ivacaftor Combination on Glucose Tolerance in Young People With Cystic Fibrosis-An Observational Pilot Study.
Korten I, Kieninger E, Krueger L, Bullo M, Flück CE, Latzin P, Casaulta C, Boettcher C. Korten I, et al. Among authors: kieninger e. Front Pediatr. 2022 Apr 21;10:852551. doi: 10.3389/fped.2022.852551. eCollection 2022. Front Pediatr. 2022. PMID: 35529332 Free PMC article.
BACKGROUND: The effect of elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA) on glucose tolerance and/or cystic-fibrosis-related diabetes (CFRD) is not well understood. We performed an observational study on the short-term effects of ELX/TEZ/IVA on glucose tolerance. METHODS: …
BACKGROUND: The effect of elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA) on glucose tolerance and/or cystic-fibrosis-related diabetes (CFRD) …
Effect of Salbutamol on Lung Ventilation in Children with Cystic Fibrosis: Comprehensive Assessment Using Spirometry, Multiple-Breath Washout, and Functional Lung Magnetic Resonance Imaging.
Kieninger E, Willers C, Röthlisberger K, Yammine S, Pusterla O, Bauman G, Stranzinger E, Bieri O, Latzin P, Casaulta C. Kieninger E, et al. Respiration. 2022;101(3):281-290. doi: 10.1159/000519751. Epub 2021 Nov 22. Respiration. 2022. PMID: 34808631
We could not identify specific clinical factors associated with a more pronounced effect of salbutamol. CONCLUSIONS: There is a positive short-term effect of bronchodilator inhalation on FEV1 in patients with CF, which is independent of ventilation inhomogeneity. ...
We could not identify specific clinical factors associated with a more pronounced effect of salbutamol. CONCLUSIONS: There is a positive sho …
Rhinovirus Infections and Associated Respiratory Morbidity in Infants: A Prospective Cohort Study.
Mack I, Kieninger E, Cangiano G, Tapparel C, Kuehni C, Spycher B, Kaiser L, Frey U, Regamey N, Latzin P. Mack I, et al. Among authors: kieninger e. Pediatr Infect Dis J. 2016 Oct;35(10):1069-74. doi: 10.1097/INF.0000000000001240. Pediatr Infect Dis J. 2016. PMID: 27254029
OBJECTIVES: To determine the frequency of symptomatic and asymptomatic RV infections and identify possible risk factors from host and environment among otherwise healthy infants. METHODS: In a prospective birth cohort, respiratory health was assessed in 41 term-born …
OBJECTIVES: To determine the frequency of symptomatic and asymptomatic RV infections and identify possible risk factors from host and enviro …
False normal Lung Clearance Index in infants with cystic fibrosis due to software algorithms.
Anagnostopoulou P, Yammine S, Schmidt A, Korten I, Kieninger E, Mack I, Trachsel D, Hafen G, Moeller A, Casaulta C, Latzin P. Anagnostopoulou P, et al. Among authors: kieninger e. Pediatr Pulmonol. 2015 Oct;50(10):970-7. doi: 10.1002/ppul.23256. Epub 2015 Aug 18. Pediatr Pulmonol. 2015. PMID: 26285162
METHODS: We compared multiple breath washout (MBW) results of current software algorithms (automatic modus) to refined algorithms (manual modus) in 17 asymptomatic infants with CF, and 24 matched healthy term-born infants. The main difference between these two analysis met …
METHODS: We compared multiple breath washout (MBW) results of current software algorithms (automatic modus) to refined algorithms (manual mo …
Rhinovirus infections in infancy and early childhood.
Kieninger E, Fuchs O, Latzin P, Frey U, Regamey N. Kieninger E, et al. Eur Respir J. 2013 Feb;41(2):443-52. doi: 10.1183/09031936.00203511. Epub 2012 Jun 27. Eur Respir J. 2013. PMID: 22743674 Free article. Review.
They are the most frequent causative agents of both upper and lower respiratory tract infections in this age group and are associated with a broad variety of clinical outcomes, ranging from asymptomatic infections to severe respiratory disease requiring hospitalisation. In additi …
They are the most frequent causative agents of both upper and lower respiratory tract infections in this age group and are associated with a …
Impaired type I and type III interferon induction and rhinovirus control in human cystic fibrosis airway epithelial cells.
Vareille M, Kieninger E, Alves MP, Kopf BS, Möller A, Geiser T, Johnston SL, Edwards MR, Regamey N. Vareille M, et al. Among authors: kieninger e. Thorax. 2012 Jun;67(6):517-25. doi: 10.1136/thoraxjnl-2011-200405. Epub 2012 Jan 2. Thorax. 2012. PMID: 22213737 Retracted.
BACKGROUND: Rhinoviruses are important triggers of pulmonary exacerbations and possible contributors to long-term respiratory morbidity in cystic fibrosis (CF), but mechanisms leading to rhinovirus-induced CF exacerbations are poorly understood. ...
BACKGROUND: Rhinoviruses are important triggers of pulmonary exacerbations and possible contributors to long-term respiratory morbidi …
Long-term course of lung clearance index between infancy and school-age in cystic fibrosis subjects.
Kieninger E, Singer F, Fuchs O, Abbas C, Frey U, Regamey N, Casaulta C, Latzin P. Kieninger E, et al. J Cyst Fibros. 2011 Dec;10(6):487-90. doi: 10.1016/j.jcf.2011.07.006. Epub 2011 Aug 10. J Cyst Fibros. 2011. PMID: 21835702 Free article.
Tracking of LCI at follow-up was evident only in the four most severe cases. We provide the first longitudinal data describing the long-term course of LCI in a small group of infants with CF. Our findings support the clinical usefulness of MBW measurements to detect and mo …
Tracking of LCI at follow-up was evident only in the four most severe cases. We provide the first longitudinal data describing the long-t
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