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ECFS standards of care on CFTR-related disorders: Towards a comprehensive program for affected individuals.
De Wachter E, De Boeck K, Sermet-Gaudelus I, Simmonds NJ, Munck A, Naehrlich L, Barben J, Boyd C, Veen SJ, Carr SB, Fajac I, Farrell PM, Girodon E, Gonska T, Grody WW, Jain M, Jung A, Kerem E, Raraigh KS, van Koningsbruggen-Rietschel S, Waller MD, Southern KW, Castellani C; ECFS Diagnostic Network Working Group. De Wachter E, et al. Among authors: kerem e. J Cyst Fibros. 2024 Feb 21:S1569-1993(24)00011-0. doi: 10.1016/j.jcf.2024.01.012. Online ahead of print. J Cyst Fibros. 2024. PMID: 38388234
Topics included are: 1) benefits and obstacles to collect data from pwCFTR-RD are discussed, together with the opportunity to integrate them into established CF-registries; 2) the potential of infants designated CRMS/CFSPID to develop a CFTR-RD and how to communicate this informa …
Topics included are: 1) benefits and obstacles to collect data from pwCFTR-RD are discussed, together with the opportunity to integrate them …
Ethical Dilemma: Elexacaftor-Tezacaftor-Ivacaftor or Lung Transplantation in Cystic Fibrosis and End-Stage Lung Disease?
Breuer O, Shoseyov D, Koretz S, Alyan N, Reiter J, Cohen-Cymberknoh M, Wexler I, Kerem E. Breuer O, et al. Among authors: kerem e. Chest. 2022 Mar;161(3):773-780. doi: 10.1016/j.chest.2021.08.073. Epub 2021 Oct 7. Chest. 2022. PMID: 34506793 Review.
In summary, CFTR modulators affect the outcomes of CF disease and influence clinical decision-making. The current lack of data on long-term outcomes, in young patients with CF receiving effective modulator therapy, should not preclude CF team participation in decision-maki …
In summary, CFTR modulators affect the outcomes of CF disease and influence clinical decision-making. The current lack of data on long-te …
Long-term safety and efficacy of tezacaftor-ivacaftor in individuals with cystic fibrosis aged 12 years or older who are homozygous or heterozygous for Phe508del CFTR (EXTEND): an open-label extension study.
Flume PA, Biner RF, Downey DG, Brown C, Jain M, Fischer R, De Boeck K, Sawicki GS, Chang P, Paz-Diaz H, Rubin JL, Yang Y, Hu X, Pasta DJ, Millar SJ, Campbell D, Wang X, Ahluwalia N, Owen CA, Wainwright CE; VX14-661-110 study group. Flume PA, et al. Lancet Respir Med. 2021 Jul;9(7):733-746. doi: 10.1016/S2213-2600(20)30510-5. Epub 2021 Feb 10. Lancet Respir Med. 2021. PMID: 33581080
Here, we present results of study 661-110 (EXTEND), a 96-week open-label extension study that assessed long-term safety, tolerability, and efficacy of tezacaftor-ivacaftor in participants aged 12 years or older with cystic fibrosis who were homozygous or heterozygous for t …
Here, we present results of study 661-110 (EXTEND), a 96-week open-label extension study that assessed long-term safety, tolerability …
Persistent Tachypnea of Infancy. Usual and Aberrant.
Rauch D, Wetzke M, Reu S, Wesselak W, Schams A, Hengst M, Kammer B, Ley-Zaporozhan J, Kappler M, Proesmans M, Lange J, Escribano A, Kerem E, Ahrens F, Brasch F, Schwerk N, Griese M; PTI (Persistent Tachypnea of Infancy) Study Group of the Kids Lung Register. Rauch D, et al. Among authors: kerem e. Am J Respir Crit Care Med. 2016 Feb 15;193(4):438-47. doi: 10.1164/rccm.201508-1655OC. Am J Respir Crit Care Med. 2016. PMID: 26474448 Free article.
OBJECTIVES: To determine whether infants with the characteristic clinical presentation and computed tomographic (CT) imaging of NEHI (referred to as "usual PTI") have long-term outcome and biopsy findings similar to those of infants with an aberrant presentation and/or wit …
OBJECTIVES: To determine whether infants with the characteristic clinical presentation and computed tomographic (CT) imaging of NEHI (referr …
[How can asthma in children be controlled?].
Rousso S, Shoseyov D, Kerem E. Rousso S, et al. Among authors: kerem e. Harefuah. 2013 May;152(5):299-303, 307. Harefuah. 2013. PMID: 23885456 Review. Hebrew.
These exacerbations are caused by an increased inflammatory process in the airways. This review focuses on the various daily long term control medications used to prevent exacerbations. The pharmacotherapy used to manage asthma is based mainly on inhaled corticosteroids (I …
These exacerbations are caused by an increased inflammatory process in the airways. This review focuses on the various daily long term …
Meconium ileus in patients with cystic fibrosis is not a risk factor for clinical deterioration and survival: the Israeli Multicenter Study.
Efrati O, Nir J, Fraser D, Cohen-Cymberknoh M, Shoseyov D, Vilozni D, Modan-Moses D, Levy R, Szeinberg A, Kerem E, Rivlin J. Efrati O, et al. Among authors: kerem e. J Pediatr Gastroenterol Nutr. 2010 Feb;50(2):173-8. doi: 10.1097/MPG.0b013e3181a3bfdd. J Pediatr Gastroenterol Nutr. 2010. PMID: 19668004
Bacterial colonization, z score of body mass index, and pulmonary function tests were similar in patients with and without MI in the long term. In younger patients, many clinical parameters were more prevalent in patients with MI (P = 0.004). However, these differences dis …
Bacterial colonization, z score of body mass index, and pulmonary function tests were similar in patients with and without MI in the long …
Nasal potential difference in non-classic cystic fibrosis-long term follow up.
Jaron R, Yaakov Y, Rivlin J, Blau H, Bentur L, Yahav Y, Kerem E, Bibi H, Picard E, Wilschanski M. Jaron R, et al. Among authors: kerem e. Pediatr Pulmonol. 2008 Jun;43(6):545-9. doi: 10.1002/ppul.20807. Pediatr Pulmonol. 2008. PMID: 18433042 Free article.
BACKGROUND: Nasal potential difference (NPD) measurement is an electrophysiological test that assesses cystic fibrosis transmembrane conductance regulator (CFTR) activity and is a recognized diagnostic tool in CF. The aim of this study is to assess in the long term the rol …
BACKGROUND: Nasal potential difference (NPD) measurement is an electrophysiological test that assesses cystic fibrosis transmembrane conduct …
Long term nutritional rehabilitation by gastrostomy in Israeli patients with cystic fibrosis: clinical outcome in advanced pulmonary disease.
Efrati O, Mei-Zahav M, Rivlin J, Kerem E, Blau H, Barak A, Bujanover Y, Augarten A, Cochavi B, Yahav Y, Modan-Moses D. Efrati O, et al. Among authors: kerem e. J Pediatr Gastroenterol Nutr. 2006 Feb;42(2):222-8. doi: 10.1097/01.mpg.0000189348.09925.02. J Pediatr Gastroenterol Nutr. 2006. PMID: 16456419
Our study aims were: 1) To evaluate the effect of nutritional supplementation via gastrostomy on nutritional, clinical, and pulmonary parameters, and 2) To identify predicting factors for success of long-term nutritional rehabilitation. METHODS: Twenty-one Israeli patients …
Our study aims were: 1) To evaluate the effect of nutritional supplementation via gastrostomy on nutritional, clinical, and pulmonary parame …
Efficacy of corticosteroids in acute bronchiolitis: short-term and long-term follow-up.
Berger I, Argaman Z, Schwartz SB, Segal E, Kiderman A, Branski D, Kerem E. Berger I, et al. Among authors: kerem e. Pediatr Pulmonol. 1998 Sep;26(3):162-6. doi: 10.1002/(sici)1099-0496(199809)26:3<162::aid-ppul2>3.0.co;2-n. Pediatr Pulmonol. 1998. PMID: 9773910 Clinical Trial.
Corticosteroids continue to be used by many physicians to treat infants with bronchiolitis. The aim of this study was to examine the short-term and long-term efficacy of oral corticosteroid therapy when added to beta2-agonists in infants with mild to moderate bronch …
Corticosteroids continue to be used by many physicians to treat infants with bronchiolitis. The aim of this study was to examine the short- …