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Mapping the Proteoform Landscape of Five Human Tissues.
Drown BS, Jooß K, Melani RD, Lloyd-Jones C, Camarillo JM, Kelleher NL. Drown BS, et al. Among authors: kelleher nl. J Proteome Res. 2022 May 6;21(5):1299-1310. doi: 10.1021/acs.jproteome.2c00034. Epub 2022 Apr 12. J Proteome Res. 2022. PMID: 35413190 Free PMC article.
The chemical structure of proteins is controlled at the transcriptional, translational, and post-translational levels, creating a variety of products with modulated functions within the cell. The term "proteoform" encapsulates this complexity at the level of chemical compo …
The chemical structure of proteins is controlled at the transcriptional, translational, and post-translational levels, creating a variety of …
Reducing protein oxidation in low-flow electrospray enables deeper investigation of proteoforms by top down proteomics.
Kim K, Compton PD, Toby TK, Thomas PM, Wilkins JT, Mutharasan RK, Kelleher NL. Kim K, et al. Among authors: kelleher nl. EuPA Open Proteom. 2015 Sep;8:40-47. doi: 10.1016/j.euprot.2015.05.005. Epub 2015 Jun 5. EuPA Open Proteom. 2015. PMID: 26753126 Free PMC article.
All of these effects are accentuated in comparison to bottom up proteomics due to the increased probability of having oxidizable residues within a particular species with increasing mass. Herein, we describe a configuration (which we term "Low Protein Oxidation (LPOx)") fo …
All of these effects are accentuated in comparison to bottom up proteomics due to the increased probability of having oxidizable residues wi …
Top-down proteomics with mass spectrometry imaging: a pilot study towards discovery of biomarkers for neurodevelopmental disorders.
Ye H, Mandal R, Catherman A, Thomas PM, Kelleher NL, Ikonomidou C, Li L. Ye H, et al. Among authors: kelleher nl. PLoS One. 2014 Apr 7;9(4):e92831. doi: 10.1371/journal.pone.0092831. eCollection 2014. PLoS One. 2014. PMID: 24710523 Free PMC article.
Overall, our findings indicate that a brief neonatal exposure to a compound that alters excitatory/inhibitory balance in the brain has a long term effect on protein expression patterns during subsequent development, highlighting the utility of MALDI-MSI as a discovery tool …
Overall, our findings indicate that a brief neonatal exposure to a compound that alters excitatory/inhibitory balance in the brain has a lon …
Proteoform: a single term describing protein complexity.
Smith LM, Kelleher NL; Consortium for Top Down Proteomics. Smith LM, et al. Among authors: kelleher nl. Nat Methods. 2013 Mar;10(3):186-7. doi: 10.1038/nmeth.2369. Nat Methods. 2013. PMID: 23443629 Free PMC article. No abstract available.
Global histone profiling by LC-FTMS after inhibition and knockdown of deacetylases in human cells.
Li M, Jiang L, Kelleher NL. Li M, et al. Among authors: kelleher nl. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Nov 15;877(30):3885-92. doi: 10.1016/j.jchromb.2009.09.042. Epub 2009 Oct 1. J Chromatogr B Analyt Technol Biomed Life Sci. 2009. PMID: 19828382 Free PMC article.
Global histone modifications and their putative relevance to short and long term cellular programming have drawn substantial interest in the study of chromatin. ...
Global histone modifications and their putative relevance to short and long term cellular programming have drawn substantial interest …