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High-Sensitivity Cardiac Troponin I Thresholds to Identify Myocardial Injury After Noncardiac Surgery: A Cohort Study.
Duceppe E, Borges FK, Tiboni M, Pearse R, Chan MTV, Srinathan S, Kavsak PA, Garg AX, Sessler DI, Sapsford R, Heels-Ansdell D, Pettit S, Vasquez J, Mueller C, Walsh M, Szczeklik W, Rodseth R, Lalu M, Thabane L, Guyatt G, Devereaux PJ. Duceppe E, et al. Among authors: kavsak pa. Can J Cardiol. 2023 Mar;39(3):311-318. doi: 10.1016/j.cjca.2023.01.008. Epub 2023 Jan 20. Can J Cardiol. 2023. PMID: 36682485
BACKGROUND: Myocardial injury after noncardiac surgery (MINS) is common and associated with short- and long-term major cardiovascular events. Diagnostic criteria for MINS using Abbott high-sensitivity cardiac troponin I (hs-cTnI) are unknown. ...
BACKGROUND: Myocardial injury after noncardiac surgery (MINS) is common and associated with short- and long-term major cardiovascular …
Cardiac Troponin Testing in Patients with COVID-19: A Strategy for Testing and Reporting Results.
Kavsak PA, Hammarsten O, Worster A, Smith SW, Apple FS. Kavsak PA, et al. Clin Chem. 2021 Jan 8;67(1):107-113. doi: 10.1093/clinchem/hvaa225. Clin Chem. 2021. PMID: 33045044 Free PMC article. Review.
CONTENT: The purpose of this mini-review is: a) to review the pathophysiology of SARS-CoV-2 and the cardiovascular system, b) to overview the strengths and weaknesses of selected studies evaluating cardiac troponin in patients with COVID-19, and c) to recommend testing strategies …
CONTENT: The purpose of this mini-review is: a) to review the pathophysiology of SARS-CoV-2 and the cardiovascular system, b) to overview th …
Analytical performance of cardiac troponin assays - Current status and future needs.
Aakre KM, Saeed N, Wu AHB, Kavsak PA. Aakre KM, et al. Among authors: kavsak pa. Clin Chim Acta. 2020 Oct;509:149-155. doi: 10.1016/j.cca.2020.06.021. Epub 2020 Jun 12. Clin Chim Acta. 2020. PMID: 32540128 Free article. Review.
The hs-cTn assays were also important for the detection and monitoring of low-grade chronic myocardial injury, a condition that has been linked to increased long-term risk of cardiovascular morbidity and mortality. This review summarizes the general recommendations for def …
The hs-cTn assays were also important for the detection and monitoring of low-grade chronic myocardial injury, a condition that has been lin …
Application of High-Sensitivity Troponin in Suspected Myocardial Infarction.
Neumann JT, Twerenbold R, Ojeda F, Sörensen NA, Chapman AR, Shah ASV, Anand A, Boeddinghaus J, Nestelberger T, Badertscher P, Mokhtari A, Pickering JW, Troughton RW, Greenslade J, Parsonage W, Mueller-Hennessen M, Gori T, Jernberg T, Morris N, Liebetrau C, Hamm C, Katus HA, Münzel T, Landmesser U, Salomaa V, Iacoviello L, Ferrario MM, Giampaoli S, Kee F, Thorand B, Peters A, Borchini R, Jørgensen T, Söderberg S, Sans S, Tunstall-Pedoe H, Kuulasmaa K, Renné T, Lackner KJ, Worster A, Body R, Ekelund U, Kavsak PA, Keller T, Lindahl B, Wild P, Giannitsis E, Than M, Cullen LA, Mills NL, Mueller C, Zeller T, Westermann D, Blankenberg S; COMPASS-MI Study Group. Neumann JT, et al. Among authors: kavsak pa. N Engl J Med. 2019 Jun 27;380(26):2529-2540. doi: 10.1056/NEJMoa1803377. N Engl J Med. 2019. PMID: 31242362
Lower high-sensitivity troponin concentrations at presentation and smaller absolute changes during serial sampling were associated with a lower likelihood of myocardial infarction and a lower short-term risk of cardiovascular events. For example, high-sensitivity troponin …
Lower high-sensitivity troponin concentrations at presentation and smaller absolute changes during serial sampling were associated with a lo …
Evaluation of the Siemens ADVIA Centaur high-sensitivity cardiac troponin I assay in serum.
Kavsak PA, Worster A, Hill SA, Jaffe AS. Kavsak PA, et al. Clin Chim Acta. 2018 Dec;487:216-221. doi: 10.1016/j.cca.2018.10.012. Epub 2018 Oct 6. Clin Chim Acta. 2018. PMID: 30296440
We evaluated the Siemens ADVIA Centaur hs-cTnI assay in serum and thereby provide information on imprecision, long-term storage stability, freeze-thaw stability, method comparison to other hs-cTnI assays, and clinical performance. ...CONCLUSIONS: In serum, the Siemens ADVI …
We evaluated the Siemens ADVIA Centaur hs-cTnI assay in serum and thereby provide information on imprecision, long-term storage stabi …
Contemporary Emergency Department Management of Patients with Chest Pain: A Concise Review and Guide for the High-Sensitivity Troponin Era.
Andruchow JE, Kavsak PA, McRae AD. Andruchow JE, et al. Among authors: kavsak pa. Can J Cardiol. 2018 Feb;34(2):98-108. doi: 10.1016/j.cjca.2017.11.012. Epub 2017 Dec 2. Can J Cardiol. 2018. PMID: 29407013 Review.
These patients pose a disposition challenge to clinicians because although the differential diagnosis of elevated troponin concentrations is broad, these patients have an increased risk for short-term major adverse cardiac events. Use of repeated serial troponin sampling a …
These patients pose a disposition challenge to clinicians because although the differential diagnosis of elevated troponin concentrations is …
Analytical comparison of three different versions of a high-sensitivity cardiac troponin I assay over 10years.
Kavsak PA, Worster A, Hill SA, MacRae AR, Jaffe AS. Kavsak PA, et al. Clin Chim Acta. 2017 Dec;475:51-55. doi: 10.1016/j.cca.2017.10.006. Epub 2017 Oct 7. Clin Chim Acta. 2017. PMID: 29017768
BACKGROUND: Concerns have been raised on the long-term analytical performance of high-sensitivity cardiac troponin (hs-cTn) assays with respect to different reagent formulations, lots and instrumentation. ...
BACKGROUND: Concerns have been raised on the long-term analytical performance of high-sensitivity cardiac troponin (hs-cTn) assays wi …
18 results