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Systematic Analysis of Long Non-Coding RNA Genes in Nonalcoholic Fatty Liver Disease.
Ilieva M, Dao J, Miller HE, Madsen JH, Bishop AJR, Kauppinen S, Uchida S. Ilieva M, et al. Among authors: kauppinen s. Noncoding RNA. 2022 Jul 22;8(4):56. doi: 10.3390/ncrna8040056. Noncoding RNA. 2022. PMID: 35893239 Free PMC article.
., rich in processed carbohydrates and saturated fats), and cardiometabolic diseases are interlinked to liver diseases, including non-alcoholic fatty liver disease (NAFLD), which is a collective term to describe the excess accumulation of fat in the liver of people who dri …
., rich in processed carbohydrates and saturated fats), and cardiometabolic diseases are interlinked to liver diseases, including non-alcoho …
Three-year mortality in 30-day survivors of critical care with acute kidney injury: data from the prospective observational FINNAKI study.
Mildh H, Pettilä V, Korhonen AM, Karlsson S, Ala-Kokko T, Reinikainen M, Vaara ST; FINNAKI Study Group. Mildh H, et al. Ann Intensive Care. 2016 Dec;6(1):118. doi: 10.1186/s13613-016-0218-5. Epub 2016 Nov 29. Ann Intensive Care. 2016. PMID: 27900737 Free PMC article.
BACKGROUND: The role of an episode of acute kidney injury (AKI) in long-term mortality among initial survivors of critical illness is controversial. ...
BACKGROUND: The role of an episode of acute kidney injury (AKI) in long-term mortality among initial survivors of critical illness is …
Predicting one-year mortality of critically ill patients with early acute kidney injury: data from the prospective multicenter FINNAKI study.
Poukkanen M, Vaara ST, Reinikainen M, Selander T, Nisula S, Karlsson S, Parviainen I, Koskenkari J, Pettilä V; FINNAKI Study Group. Poukkanen M, et al. Crit Care. 2015 Mar 27;19(1):125. doi: 10.1186/s13054-015-0848-2. Crit Care. 2015. PMID: 25887685 Free PMC article.
INTRODUCTION: No predictive models for long-term mortality in critically ill patients with acute kidney injury (AKI) exist. ...
INTRODUCTION: No predictive models for long-term mortality in critically ill patients with acute kidney injury (AKI) exist. ...
Copeptin levels are associated with organ dysfunction and death in the intensive care unit after out-of-hospital cardiac arrest.
Ristagno G, Latini R, Plebani M, Zaninotto M, Vaahersalo J, Masson S, Tiainen M, Kurola J, Gaspari F, Milani V, Pettilä V, Skrifvars MB; FINNRESUSCI Study Group. Ristagno G, et al. Crit Care. 2015 Mar 31;19(1):132. doi: 10.1186/s13054-015-0831-y. Crit Care. 2015. PMID: 25886856 Free PMC article.
Cortisol levels did not change between admission and 48 hours (P = 0.313), independently of outcome (P = 0.221). The AUC for predicting long-term outcome was weak for copeptin (0.62, 95% CI 0.55 to 0.69) and cortisol (0.62, 95% CI 0.54 to 0.69). ...
Cortisol levels did not change between admission and 48 hours (P = 0.313), independently of outcome (P = 0.221). The AUC for predicting long …
Admission interleukin-6 is associated with post resuscitation organ dysfunction and predicts long-term neurological outcome after out-of-hospital ventricular fibrillation.
Vaahersalo J, Skrifvars MB, Pulkki K, Stridsberg M, Røsjø H, Hovilehto S, Tiainen M, Varpula T, Pettilä V, Ruokonen E; FINNRESUSCI Laboratory Study Group. Vaahersalo J, et al. Resuscitation. 2014 Nov;85(11):1573-9. doi: 10.1016/j.resuscitation.2014.08.036. Epub 2014 Sep 17. Resuscitation. 2014. PMID: 25238742
AIM OF THE STUDY: To study plasma concentrations of interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs-CRP) and S-100B during intensive care after out-of-hospital cardiac arrest from ventricular fibrillation (OHCA-VF), and their associations with the duration of ischem …
AIM OF THE STUDY: To study plasma concentrations of interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs-CRP) and S-100B during int …
Pharmacological inhibition of a microRNA family in nonhuman primates by a seed-targeting 8-mer antimiR.
Rottiers V, Obad S, Petri A, McGarrah R, Lindholm MW, Black JC, Sinha S, Goody RJ, Lawrence MS, deLemos AS, Hansen HF, Whittaker S, Henry S, Brookes R, Najafi-Shoushtari SH, Chung RT, Whetstine JR, Gerszten RE, Kauppinen S, Näär AM. Rottiers V, et al. Among authors: kauppinen s. Sci Transl Med. 2013 Nov 20;5(212):212ra162. doi: 10.1126/scitranslmed.3006840. Sci Transl Med. 2013. PMID: 24259050 Free PMC article.
We recently demonstrated effective inhibition of entire miRNA families using seed-targeting 8-mer locked nucleic acid (LNA)-modified antimiRs in short-term experiments in mammalian cells and in mice. However, the long-term efficacy and safety of this approach in hig …
We recently demonstrated effective inhibition of entire miRNA families using seed-targeting 8-mer locked nucleic acid (LNA)-modified antimiR …
Age of red blood cells and outcome in acute kidney injury.
Kaukonen KM, Vaara ST, Pettilä V, Bellomo R, Tuimala J, Cooper DJ, Krusius T, Kuitunen A, Reinikainen M, Koskenkari J, Uusaro A; FINNAKI study group. Kaukonen KM, et al. Crit Care. 2013 Oct 4;17(5):R222. doi: 10.1186/cc13045. Crit Care. 2013. PMID: 24093554 Free PMC article.
INTRODUCTION: Transfusion of red blood cells (RBCs) and, in particular, older RBCs has been associated with increased short-term mortality in critically ill patients. We evaluated the association between age of transfused RBCs and acute kidney injury (AKI), hospital, and 9 …
INTRODUCTION: Transfusion of red blood cells (RBCs) and, in particular, older RBCs has been associated with increased short-term mort …
Silencing of microRNA families by seed-targeting tiny LNAs.
Obad S, dos Santos CO, Petri A, Heidenblad M, Broom O, Ruse C, Fu C, Lindow M, Stenvang J, Straarup EM, Hansen HF, Koch T, Pappin D, Hannon GJ, Kauppinen S. Obad S, et al. Among authors: kauppinen s. Nat Genet. 2011 Mar 20;43(4):371-8. doi: 10.1038/ng.786. Nat Genet. 2011. PMID: 21423181 Free PMC article.
In addition, systemically delivered, unconjugated tiny LNAs showed uptake in many normal tissues and in breast tumors in mice, coinciding with long-term miRNA silencing. Transcriptional and proteomic profiling suggested that tiny LNAs have negligible off-target effects, no …
In addition, systemically delivered, unconjugated tiny LNAs showed uptake in many normal tissues and in breast tumors in mice, coinciding wi …
12 results