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mTORC1 inhibition impairs activation of the unfolded protein response and induces cell death during ER stress in cardiomyocytes.
Hofmann C, Löwenthal Z, Aghajani M, Kaufman RJ, Katus HA, Frey N, Glembotski CC, Völkers M, Doroudgar S. Hofmann C, et al. Among authors: katus ha. Am J Physiol Heart Circ Physiol. 2023 Aug 1;325(2):H311-H320. doi: 10.1152/ajpheart.00682.2022. Epub 2023 Jun 9. Am J Physiol Heart Circ Physiol. 2023. PMID: 37294892 Free PMC article.
Pharmacological inhibition of mTORC1 increased cell death during ER stress, indicating that the mTORC1 pathway serves adaptive functions during ER stress in cardiomyocytes potentially by controlling the expression of protective unfolded protein response genes.NEW & NOTEWORTHY …
Pharmacological inhibition of mTORC1 increased cell death during ER stress, indicating that the mTORC1 pathway serves adaptive functions dur …
Biomarker Concentrations and Their Temporal Changes in Patients With Myocardial Infarction and Nonobstructive Compared With Obstructive Coronary Arteries: Results From the PLATO Trial.
Hjort M, Eggers KM, Lakic TG, Lindbäck J, Budaj A, Cornel JH, Giannitsis E, Katus HA, Siegbahn A, Storey RF, Becker RC, Wallentin L, Lindahl B; PLATO trial investigators*. Hjort M, et al. Among authors: katus ha. J Am Heart Assoc. 2023 Jan 3;12(1):e027466. doi: 10.1161/JAHA.122.027466. Epub 2022 Dec 24. J Am Heart Assoc. 2023. PMID: 36565198 Free PMC article. Clinical Trial.
Adjusted linear regression models were used to compare concentrations and their short- and long-term changes. The adjusted geometric mean ratios (GMRs) in patients with MINOCA (median age, 61 years; 50.4% women) indicated lower hs-cTnT (GMR, 0.77 [95% CI, 0.68-0.88]) but h …
Adjusted linear regression models were used to compare concentrations and their short- and long-term changes. The adjusted geometric …
Prognostic value of changes in high-sensitivity cardiac troponin T beyond biological variation in stable outpatients with cardiovascular disease: a validation study.
Biener M, Giannitsis E, Hogrefe K, Mueller-Hennessen M, Fröhlich H, Katus HA, Frey N, Frankenstein L, Täger T. Biener M, et al. Among authors: katus ha. Clin Res Cardiol. 2022 Mar;111(3):333-342. doi: 10.1007/s00392-021-01952-6. Epub 2021 Oct 25. Clin Res Cardiol. 2022. PMID: 34694435 Free PMC article.
OBJECTIVE: To evaluate the prognostic implications of longitudinal long-term changes beyond the biological variation of high-sensitivity cardiac troponin T (hs-cTnT) in outpatients with stable or asymptomatic cardiovascular disease (CV) and to assess possible differences i …
OBJECTIVE: To evaluate the prognostic implications of longitudinal long-term changes beyond the biological variation of high-sensitiv …
PASCAL-based mitral valve repair in an all-comer population: acute and mid-term clinical results.
Schlegel P, Crespo López P, Kreusser MM, Katus HA, Frey N, Geis NA, Raake PWJ. Schlegel P, et al. Among authors: katus ha. ESC Heart Fail. 2021 Oct;8(5):3530-3538. doi: 10.1002/ehf2.13569. Epub 2021 Aug 27. ESC Heart Fail. 2021. PMID: 34448541 Free PMC article.
AIMS: We investigated short and mid-term safety and efficacy of the PASCAL system for percutaneous mitral valve repair (PMVr) in severe mitral regurgitation (MR) in an all-comer population. ...CONCLUSIONS: Percutaneous mitral valve repair using PASCAL in a real-world, all- …
AIMS: We investigated short and mid-term safety and efficacy of the PASCAL system for percutaneous mitral valve repair (PMVr) in seve …
Impact of Atrial Fibrillation on Outcome in Takotsubo Syndrome: Data From the International Takotsubo Registry.
El-Battrawy I, Cammann VL, Kato K, Szawan KA, Di Vece D, Rossi A, Wischnewsky M, Hermes-Laufer J, Gili S, Citro R, Bossone E, Neuhaus M, Franke J, Meder B, Jaguszewski M, Noutsias M, Knorr M, Heiner S, D'Ascenzo F, Dichtl W, Burgdorf C, Kherad B, Tschöpe C, Sarcon A, Shinbane J, Rajan L, Michels G, Pfister R, Cuneo A, Jacobshagen C, Karakas M, Koenig W, Pott A, Meyer P, David Arroja J, Banning A, Cuculi F, Kobza R, Fischer TA, Vasankari T, Airaksinen KEJ, Napp LC, Budnik M, Dworakowski R, MacCarthy P, Kaiser C, Osswald S, Galiuto L, Chan C, Bridgman P, Beug D, Delmas C, Lairez O, Gilyarova E, Shilova A, Gilyarov M, Kozel M, Tousek P, Winchester DE, Galuszka J, Ukena C, Poglajen G, Carrilho-Ferreira P, Hauck C, Paolini C, Bilato C, Kobayashi Y, Prasad A, Rihal CS, Liu K, Schulze PC, Bianco M, Jörg L, Rickli H, Pestana G, Nguyen TH, Böhm M, Maier LS, Pinto FJ, Widimský P, Felix SB, Opolski G, Braun-Dullaeus RC, Rottbauer W, Hasenfuß G, Pieske BM, Schunkert H, Thiele H, Bauersachs J, Katus HA, Horowitz JD, Di Mario C, Münzel T, Crea F, Bax JJ, Lüscher TF, Ruschitzka F, Duru F, Borggrefe M, Ghadri JR, Akin I, Templin C. El-Battrawy I, et al. Among authors: katus ha. J Am Heart Assoc. 2021 Aug 3;10(15):e014059. doi: 10.1161/JAHA.119.014059. Epub 2021 Jul 28. J Am Heart Assoc. 2021. PMID: 34315238 Free PMC article.
Left ventricular ejection fraction was significantly lower (P=0.001), and cardiogenic shock was more often observed (P<0.001) in the AF group. Both in-hospital (P<0.001) and long-term mortality (P<0.001) were higher in the AF group. Multivariable Cox regression an …
Left ventricular ejection fraction was significantly lower (P=0.001), and cardiogenic shock was more often observed (P<0.001) in the AF g …
Histone deacetylase 2-dependent ventricular electrical remodeling in a porcine model of early heart failure.
Syren P, Rahm AK, Schweizer PA, Bruehl C, Katus HA, Frey N, Thomas D, Lugenbiel P. Syren P, et al. Among authors: katus ha. Life Sci. 2021 Sep 15;281:119769. doi: 10.1016/j.lfs.2021.119769. Epub 2021 Jun 26. Life Sci. 2021. PMID: 34186046
MATERIALS AND METHODS: HDAC and ion channel expression was quantified in a porcine model of early HF induced by short-term atrial tachypacing, resulting in atrial fibrillation with rapid ventricular rate response. ...
MATERIALS AND METHODS: HDAC and ion channel expression was quantified in a porcine model of early HF induced by short-term atrial tac …
Safety and effectiveness of Phoenix atherectomy for endovascular treatment in calcified common femoral artery lesions.
Kronlage M, Erbel C, Lichtenberg M, Heinrich U, Katus HA, Frey N, Giusca S, Korosoglou G. Kronlage M, et al. Among authors: katus ha. Vasa. 2021 Sep;50(5):378-386. doi: 10.1024/0301-1526/a000960. Epub 2021 Jun 22. Vasa. 2021. PMID: 34155913
The aim of this study is to investigate the procedural safety and mid-term outcomes of minimal invasive Phoenix atherectomy for the treatment of CFA lesions. ...Conclusions: The Phoenix device can be used for the effective endovascular treatment of CFA lesions, due to its …
The aim of this study is to investigate the procedural safety and mid-term outcomes of minimal invasive Phoenix atherectomy for the t …
Prognostic impact of acute pulmonary triggers in patients with takotsubo syndrome: new insights from the International Takotsubo Registry.
Kato K, Cammann VL, Napp LC, Szawan KA, Micek J, Dreiding S, Levinson RA, Petkova V, Würdinger M, Patrascu A, Sumalinog R, Gili S, Clarenbach CF, Kohler M, Wischnewsky M, Citro R, Vecchione C, Bossone E, Neuhaus M, Franke J, Meder B, Jaguszewski M, Noutsias M, Knorr M, Heiner S, D'Ascenzo F, Dichtl W, Burgdorf C, Kherad B, Tschöpe C, Sarcon A, Shinbane J, Rajan L, Michels G, Pfister R, Cuneo A, Jacobshagen C, Karakas M, Koenig W, Pott A, Meyer P, Roffi M, Banning A, Wolfrum M, Cuculi F, Kobza R, Fischer TA, Vasankari T, Airaksinen KEJ, Budnik M, Dworakowski R, MacCarthy P, Kaiser C, Osswald S, Galiuto L, Chan C, Bridgman P, Beug D, Delmas C, Lairez O, Gilyarova E, Shilova A, Gilyarov M, El-Battrawy I, Akin I, Kozel M, Tousek P, Winchester DE, Galuszka J, Ukena C, Poglajen G, Carrilho-Ferreira P, Hauck C, Paolini C, Bilato C, Sano M, Ishibashi I, Takahara M, Himi T, Kobayashi Y, Prasad A, Rihal CS, Liu K, Schulze PC, Bianco M, Jörg L, Rickli H, Pestana G, Nguyen TH, Böhm M, Maier LS, Pinto FJ, Widimský P, Felix SB, Opolski G, Braun-Dullaeus RC, Rottbauer W, Hasenfuß G, Pieske BM, Schunkert H, Borggrefe M, Thiele H, Bauersachs J, Katus HA, Horowitz JD, Di Mario C, Münzel T, C… See abstract for full author list ➔ Kato K, et al. Among authors: katus ha. ESC Heart Fail. 2021 Jun;8(3):1924-1932. doi: 10.1002/ehf2.13165. Epub 2021 Mar 13. ESC Heart Fail. 2021. PMID: 33713566 Free PMC article.
Survival analysis demonstrated that patients with an acute pulmonary trigger had the worst long-term outcome (P = 0.002). The presence of an acute pulmonary trigger was independently associated with worse long-term mortality (hazard ratio 2.12, 95% confidence interv …
Survival analysis demonstrated that patients with an acute pulmonary trigger had the worst long-term outcome (P = 0.002). The presenc …
Case series of high-risk percutaneous coronary intervention with rotational atherectomy under short-term mechanical circulatory support with TandemHeart in the setting of acute myocardial infarction.
Großekettler L, Schmack B, Katus HA, Bekeredjian R, Raake P. Großekettler L, et al. Among authors: katus ha. Eur Heart J Case Rep. 2020 Sep 16;4(4):1-6. doi: 10.1093/ehjcr/ytaa219. eCollection 2020 Aug. Eur Heart J Case Rep. 2020. PMID: 33426433 Free PMC article.
Prognostic value of texture analysis from cardiac magnetic resonance imaging in patients with Takotsubo syndrome: a machine learning based proof-of-principle approach.
Mannil M, Kato K, Manka R, von Spiczak J, Peters B, Cammann VL, Kaiser C, Osswald S, Nguyen TH, Horowitz JD, Katus HA, Ruschitzka F, Ghadri JR, Alkadhi H, Templin C. Mannil M, et al. Among authors: katus ha. Sci Rep. 2020 Nov 25;10(1):20537. doi: 10.1038/s41598-020-76432-4. Sci Rep. 2020. PMID: 33239695 Free PMC article.
Cardiac magnetic resonance (CMR) imaging has become an important technique for non-invasive diagnosis of takotsubo syndrome (TTS). The long-term prognostic value of CMR imaging in TTS has not been fully elucidated yet. ...This proof-of-principle study is the first to ident …
Cardiac magnetic resonance (CMR) imaging has become an important technique for non-invasive diagnosis of takotsubo syndrome (TTS). The long- …
137 results