Synergism of TNF-α and IFN-γ triggers inflammatory cell death, tissue damage, and mortality in SARS-CoV-2 infection and cytokine shock syndromes.
Karki R, Sharma BR, Tuladhar S, Williams EP, Zalduondo L, Samir P, Zheng M, Sundaram B, Banoth B, Malireddi RKS, Schreiner P, Neale G, Vogel P, Webby R, Jonsson CB, Kanneganti TD.
Karki R, et al.
bioRxiv [Preprint]. 2020 Nov 13:2020.10.29.361048. doi: 10.1101/2020.10.29.361048.
bioRxiv. 2020.
PMID: 33140051
Free PMC article.
Updated.
Preprint.
The findings also provide a molecular and mechanistic description for the term cytokine storm. Additionally, these results open new avenues for the treatment of other infectious and autoinflammatory diseases and cancers where TNF-alpha and IFN-gamma synergism play key path …
The findings also provide a molecular and mechanistic description for the term cytokine storm. Additionally, these results open new a …