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AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence.
Lee S, Karki R, Wang Y, Nguyen LN, Kalathur RC, Kanneganti TD. Lee S, et al. Among authors: karki r. Nature. 2021 Sep;597(7876):415-419. doi: 10.1038/s41586-021-03875-8. Epub 2021 Sep 1. Nature. 2021. PMID: 34471287 Free PMC article.
Collectively, our findings define a previously unknown regulatory and molecular interaction between AIM2, pyrin and ZBP1 that drives assembly of an AIM2-mediated multi-protein complex that we term the AIM2 PANoptosome and comprising multiple inflammasome sensors and cell d …
Collectively, our findings define a previously unknown regulatory and molecular interaction between AIM2, pyrin and ZBP1 that drives assembl …
Design and Rationale of the APPELHUS Phase 3 Open-Label Study of Factor B Inhibitor Iptacopan for Atypical Hemolytic Uremic Syndrome.
Kavanagh D, Greenbaum LA, Bagga A, Karki RG, Chen CW, Vasudevan S, Charney A, Dahlke M, Fakhouri F. Kavanagh D, et al. Among authors: karki rg. Kidney Int Rep. 2023 Apr 29;8(7):1332-1341. doi: 10.1016/j.ekir.2023.04.029. eCollection 2023 Jul. Kidney Int Rep. 2023. PMID: 37441479 Free PMC article.
Further studies are required to define the optimal duration of existing therapies, and to identify new agents that are convenient for long-term administration. Iptacopan (LNP023) is an oral, first-in-class, highly potent, proximal AP inhibitor that specifically binds facto …
Further studies are required to define the optimal duration of existing therapies, and to identify new agents that are convenient for long- …
Synergism of TNF-α and IFN-γ triggers inflammatory cell death, tissue damage, and mortality in SARS-CoV-2 infection and cytokine shock syndromes.
Karki R, Sharma BR, Tuladhar S, Williams EP, Zalduondo L, Samir P, Zheng M, Sundaram B, Banoth B, Malireddi RKS, Schreiner P, Neale G, Vogel P, Webby R, Jonsson CB, Kanneganti TD. Karki R, et al. bioRxiv [Preprint]. 2020 Nov 13:2020.10.29.361048. doi: 10.1101/2020.10.29.361048. bioRxiv. 2020. PMID: 33140051 Free PMC article. Updated. Preprint.
The findings also provide a molecular and mechanistic description for the term cytokine storm. Additionally, these results open new avenues for the treatment of other infectious and autoinflammatory diseases and cancers where TNF-alpha and IFN-gamma synergism play key path …
The findings also provide a molecular and mechanistic description for the term cytokine storm. Additionally, these results open new a …
Predicted N-terminal N-linked glycosylation sites may underlie membrane protein expression patterns in Saccharomyces cerevisiae.
Karki R, Rimal S, Rieth MD. Karki R, et al. Yeast. 2021 Sep;38(9):497-506. doi: 10.1002/yea.3657. Epub 2021 Jul 5. Yeast. 2021. PMID: 34182612
Multiple strategies are presented in this article, which suggest different methods that can be implemented to circumvent the unwanted consequences of N-linked glycosylation during the expression process. These considerations may have long-term benefits for high-level prote …
Multiple strategies are presented in this article, which suggest different methods that can be implemented to circumvent the unwanted conseq …
Defining "mutation" and "polymorphism" in the era of personal genomics.
Karki R, Pandya D, Elston RC, Ferlini C. Karki R, et al. BMC Med Genomics. 2015 Jul 15;8:37. doi: 10.1186/s12920-015-0115-z. BMC Med Genomics. 2015. PMID: 26173390 Free PMC article.
We propose to solve this nomenclature dilemma by defining mutations as DNA variants obtained in a paired sequencing project including the germline DNA of the same individual as a reference. Moreover, the term mutation should be accompanied by a qualifying prefix indicating …
We propose to solve this nomenclature dilemma by defining mutations as DNA variants obtained in a paired sequencing project including the ge …
Effects of an intervention on health behaviors of older coronary artery bypass (CAB) patients.
Kummel M, Vahlberg T, Ojanlatva A, Kärki R, Mattila T, Kivelä SL. Kummel M, et al. Among authors: karki r. Arch Gerontol Geriatr. 2008 Mar-Apr;46(2):227-44. doi: 10.1016/j.archger.2007.04.003. Epub 2007 May 22. Arch Gerontol Geriatr. 2008. PMID: 17517442 Clinical Trial.
Effectiveness of cardiac rehabilitation among the elderly is not yet adequately known about. The purpose was to describe short-term (3-month), intermediate (6-month), and long-term (12-month) effects of health counseling, guidance, and adjustment education in groups …
Effectiveness of cardiac rehabilitation among the elderly is not yet adequately known about. The purpose was to describe short-term ( …