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Lyophilization provides long-term stability for a lipid nanoparticle-formulated, nucleoside-modified mRNA vaccine.
Muramatsu H, Lam K, Bajusz C, Laczkó D, Karikó K, Schreiner P, Martin A, Lutwyche P, Heyes J, Pardi N. Muramatsu H, et al. Among authors: kariko k. Mol Ther. 2022 May 4;30(5):1941-1951. doi: 10.1016/j.ymthe.2022.02.001. Epub 2022 Feb 4. Mol Ther. 2022. PMID: 35131437 Free PMC article.
They are effective, safe, and can be produced in large quantities. However, the long-term storage of mRNA-LNP vaccines without freezing is still a challenge. ...Importantly, we show in comparative mouse studies that lyophilized firefly luciferase-encoding mRNA-LNPs maintai …
They are effective, safe, and can be produced in large quantities. However, the long-term storage of mRNA-LNP vaccines without freezi …
Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies.
Pardi N, Parkhouse K, Kirkpatrick E, McMahon M, Zost SJ, Mui BL, Tam YK, Karikó K, Barbosa CJ, Madden TD, Hope MJ, Krammer F, Hensley SE, Weissman D. Pardi N, et al. Among authors: kariko k. Nat Commun. 2018 Aug 22;9(1):3361. doi: 10.1038/s41467-018-05482-0. Nat Commun. 2018. PMID: 30135514 Free PMC article.
Currently available influenza virus vaccines have inadequate effectiveness and are reformulated annually due to viral antigenic drift. Thus, development of a vaccine that confers long-term protective immunity against antigenically distant influenza virus strains is urgentl …
Currently available influenza virus vaccines have inadequate effectiveness and are reformulated annually due to viral antigenic drift. Thus, …
Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses.
Pardi N, Hogan MJ, Naradikian MS, Parkhouse K, Cain DW, Jones L, Moody MA, Verkerke HP, Myles A, Willis E, LaBranche CC, Montefiori DC, Lobby JL, Saunders KO, Liao HX, Korber BT, Sutherland LL, Scearce RM, Hraber PT, Tombácz I, Muramatsu H, Ni H, Balikov DA, Li C, Mui BL, Tam YK, Krammer F, Karikó K, Polacino P, Eisenlohr LC, Madden TD, Hope MJ, Lewis MG, Lee KK, Hu SL, Hensley SE, Cancro MP, Haynes BF, Weissman D. Pardi N, et al. Among authors: kariko k. J Exp Med. 2018 Jun 4;215(6):1571-1588. doi: 10.1084/jem.20171450. Epub 2018 May 8. J Exp Med. 2018. PMID: 29739835 Free PMC article.
T follicular helper (Tfh) cells are required to develop germinal center (GC) responses and drive immunoglobulin class switch, affinity maturation, and long-term B cell memory. In this study, we characterize a recently developed vaccine platform, nucleoside-modified, purifi …
T follicular helper (Tfh) cells are required to develop germinal center (GC) responses and drive immunoglobulin class switch, affinity matur …
Thermal preconditioning before rat arterial balloon injury: limitation of injury and sustained reduction of intimal thickening.
Neschis DG, Safford SD, Raghunath PN, Langer DJ, David ML, Hanna AK, Tomaszewski JE, Kariko K, Barnathan ES, Golden MA. Neschis DG, et al. Among authors: kariko k. Arterioscler Thromb Vasc Biol. 1998 Jan;18(1):120-6. doi: 10.1161/01.atv.18.1.120. Arterioscler Thromb Vasc Biol. 1998. PMID: 9445265
These results suggest that thermal preconditioning of vascular tissue may be an effective strategy to improve long-term results after revascularization procedures....
These results suggest that thermal preconditioning of vascular tissue may be an effective strategy to improve long-term results after …
Characterization of urokinase receptor expression by human placental trophoblasts.
Zini JM, Murray SC, Graham CH, Lala PK, Karikó K, Barnathan ES, Mazar A, Henkin J, Cines DB, McCrae KR. Zini JM, et al. Among authors: kariko k. Blood. 1992 Jun 1;79(11):2917-29. Blood. 1992. PMID: 1316787 Free article.
Trophoblasts derived from two first-trimester placentae bound more prourokinase than cells isolated from term placentae. Furthermore, in vitro differentiation of cultured cytotrophoblasts into syncytiotrophoblasts was associated with diminished expression of urokinase rece …
Trophoblasts derived from two first-trimester placentae bound more prourokinase than cells isolated from term placentae. Furthermore, …