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Biologic agents in rheumatology: unmet issues after 200 trials and $200 billion sales.
Ioannidis JP, Karassa FB, Druyts E, Thorlund K, Mills EJ. Ioannidis JP, et al. Among authors: karassa fb. Nat Rev Rheumatol. 2013 Nov;9(11):665-73. doi: 10.1038/nrrheum.2013.134. Epub 2013 Sep 3. Nat Rev Rheumatol. 2013. PMID: 23999553 Review.
We propose that improvements in the evidence regarding biologic treatments that are continually being added to the therapeutic armamentarium for rheumatic diseases might require revisiting the design and conduct of studies. For example, trials with long-term follow-up that …
We propose that improvements in the evidence regarding biologic treatments that are continually being added to the therapeutic armamentarium …