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First-Line Nivolumab Plus Chemotherapy for Advanced Gastric, Gastroesophageal Junction, and Esophageal Adenocarcinoma: 3-Year Follow-Up of the Phase III CheckMate 649 Trial.
Janjigian YY, Ajani JA, Moehler M, Shen L, Garrido M, Gallardo C, Wyrwicz L, Yamaguchi K, Cleary JM, Elimova E, Karamouzis M, Bruges R, Skoczylas T, Bragagnoli A, Liu T, Tehfe M, Zander T, Kowalyszyn R, Pazo-Cid R, Schenker M, Feeny K, Wang R, Lei M, Chen C, Nathani R, Shitara K. Janjigian YY, et al. Among authors: karamouzis m. J Clin Oncol. 2024 Feb 21:JCO2301601. doi: 10.1200/JCO.23.01601. Online ahead of print. J Clin Oncol. 2024. PMID: 38382001
Adding nivolumab to chemotherapy maintained clinically meaningful long-term survival benefit versus chemotherapy alone, with an acceptable safety profile, supporting the continued use of nivolumab plus chemotherapy as standard first-line treatment for advanced gastroesopha …
Adding nivolumab to chemotherapy maintained clinically meaningful long-term survival benefit versus chemotherapy alone, with an accep …
Exploiting Autophagy-Dependent Neoantigen Presentation in Tumor Microenvironment.
Koustas E, Trifylli EM, Sarantis P, Papadopoulos N, Papanikolopoulos K, Aloizos G, Damaskos C, Garmpis N, Garmpi A, Matthaios D, Karamouzis MV. Koustas E, et al. Among authors: karamouzis mv. Genes (Basel). 2023 Feb 13;14(2):474. doi: 10.3390/genes14020474. Genes (Basel). 2023. PMID: 36833401 Free PMC article. Review.
Emergence of cancer immunotherapy has already shown some remarkable results, having changed therapeutic strategy in clinical practice for several cancer types. Despite these promising long-term responses, several patients seem to lack the ability to respond to immune check …
Emergence of cancer immunotherapy has already shown some remarkable results, having changed therapeutic strategy in clinical practice for se …
Robot-Assisted Minimally Invasive Esophagectomy versus Open Esophagectomy for Esophageal Cancer: A Systematic Review and Meta-Analysis.
Esagian SM, Ziogas IA, Skarentzos K, Katsaros I, Tsoulfas G, Molena D, Karamouzis MV, Rouvelas I, Nilsson M, Schizas D. Esagian SM, et al. Among authors: karamouzis mv. Cancers (Basel). 2022 Jun 29;14(13):3177. doi: 10.3390/cancers14133177. Cancers (Basel). 2022. PMID: 35804949 Free PMC article. Review.
No other statistically significant difference was observed regarding surgical and short-term oncological outcomes. Similar findings were observed when comparing totally robotic procedures only to OE. ...
No other statistically significant difference was observed regarding surgical and short-term oncological outcomes. Similar findings w …
Nivolumab plus chemotherapy or ipilimumab in gastro-oesophageal cancer.
Shitara K, Ajani JA, Moehler M, Garrido M, Gallardo C, Shen L, Yamaguchi K, Wyrwicz L, Skoczylas T, Bragagnoli AC, Liu T, Tehfe M, Elimova E, Bruges R, Zander T, de Azevedo S, Kowalyszyn R, Pazo-Cid R, Schenker M, Cleary JM, Yanez P, Feeney K, Karamouzis MV, Poulart V, Lei M, Xiao H, Kondo K, Li M, Janjigian YY. Shitara K, et al. Among authors: karamouzis mv. Nature. 2022 Mar;603(7903):942-948. doi: 10.1038/s41586-022-04508-4. Epub 2022 Mar 23. Nature. 2022. PMID: 35322232 Free PMC article. Clinical Trial.
Treatment combining 1 mg kg(-1) nivolumab with 3 mg kg(-1) ipilimumab demonstrated clinically meaningful anti-tumour activity with a manageable safety profile in heavily pre-treated patients with advanced gastro-oesophageal cancer(12). Here we report both long-term follow- …
Treatment combining 1 mg kg(-1) nivolumab with 3 mg kg(-1) ipilimumab demonstrated clinically meaningful anti-tumour activity with a managea …
The Resistance Mechanisms of Checkpoint Inhibitors in Solid Tumors.
Koustas E, Sarantis P, Papavassiliou AG, Karamouzis MV. Koustas E, et al. Among authors: karamouzis mv. Biomolecules. 2020 Apr 25;10(5):666. doi: 10.3390/biom10050666. Biomolecules. 2020. PMID: 32344837 Free PMC article. Review.
The emergence of cancer immunotherapy has already shown some remarkable results, having changed the treatment strategy in clinical practice for solid tumors. Despite these promising long-term responses, patients seem to lack the ability to respond to immune checkpoint inhi …
The emergence of cancer immunotherapy has already shown some remarkable results, having changed the treatment strategy in clinical practice …
Physical activity and sociodemographic variables related to global health, quality of life, and psychological factors in breast cancer survivors.
Patsou ED, Alexias GT, Anagnostopoulos FG, Karamouzis MV. Patsou ED, et al. Among authors: karamouzis mv. Psychol Res Behav Manag. 2018 Sep 6;11:371-381. doi: 10.2147/PRBM.S170027. eCollection 2018. Psychol Res Behav Manag. 2018. PMID: 30233264 Free PMC article.
RESULTS: Active women had lower depressive symptoms, less anxiety, higher self-esteem, and better global health and QoL, compared to the inactive ones, even in the long term after completing treatment through survivorship. Exercise had significant positive correlations wit …
RESULTS: Active women had lower depressive symptoms, less anxiety, higher self-esteem, and better global health and QoL, compared to the ina …
The effect of opioid dependence on conventional and novel biochemical parameters of bone metabolism.
Balodimos S, Nikolaou K, Njau S, Karamouzis M, Kovatsi L. Balodimos S, et al. Among authors: karamouzis m. Am J Drug Alcohol Abuse. 2015;41(6):535-40. doi: 10.3109/00952990.2015.1068321. Epub 2015 Aug 20. Am J Drug Alcohol Abuse. 2015. PMID: 26461969
BACKGROUND: Opioids influence bone metabolism in several ways and osteoporosis associated with the long-term use of opioids is believed to be multifactorial. OBJECTIVES: To investigate the effect of opioid dependence on conventional and novel biochemical parameters of bone …
BACKGROUND: Opioids influence bone metabolism in several ways and osteoporosis associated with the long-term use of opioids is believ …
Utilization of Systemic Chemotherapy in Advanced Urothelial Cancer: A Retrospective Collaborative Study by the Hellenic Genitourinary Cancer Group (HGUCG).
Bamias A, Peroukidis S, Stamatopoulou S, Tzannis K, Koutsoukos K, Andreadis C, Bozionelou V, Pistalmatzian N, Papatsoris A, Stravodimos K, Varthalitis I, Karamouzis M, Milaki G, Agorastos A, Kentepozidis N, Androulakis N, Bompolaki I, Kalofonos H, Mavroudis D, Dimopoulos MA. Bamias A, et al. Among authors: karamouzis m. Clin Genitourin Cancer. 2016 Apr;14(2):e153-9. doi: 10.1016/j.clgc.2015.09.009. Epub 2015 Sep 25. Clin Genitourin Cancer. 2016. PMID: 26437909
BACKGROUND: Advanced urothelial cancer (AUCa) is associated with poor long-term survival. Two major concerns are related to nonexposure to cisplatin-based chemotherapy and poor outcome after relapse. ...
BACKGROUND: Advanced urothelial cancer (AUCa) is associated with poor long-term survival. Two major concerns are related to nonexposu …
Physical training in patients on hemodialysis has a beneficial effect on the levels of eicosanoid hormone-like substances.
Karamouzis I, Grekas D, Karamouzis M, Kallaras K, Stergiou-Michailidou V, Kouidi E, Deligiannis A, Vavatsi-Christaki N. Karamouzis I, et al. Among authors: karamouzis m. Hormones (Athens). 2009 Apr-Jun;8(2):129-37. doi: 10.14310/horm.2002.1229. Hormones (Athens). 2009. PMID: 19570740 Free article.
OBJECTIVE: The aim of this study was to evaluate the changes in the levels of vasoactive eicosanoid hormone-like substances PGE2, PGI2 and TXA2 in hemodialysis (HD)patients who were following a long-term physical training program during the hemodialysis session. DESIGN: A …
OBJECTIVE: The aim of this study was to evaluate the changes in the levels of vasoactive eicosanoid hormone-like substances PGE2, PGI2 and T …
Atrial natriuretic peptide decreases aorta stiffness in cholesterol-fed anesthetized rabbits.
Kallaras K, Babas G, Stergiou-Michailidou V, Karamouzis M, Zaraboukas T. Kallaras K, et al. Among authors: karamouzis m. Pharmacol Res. 2009 Oct;60(4):324-31. doi: 10.1016/j.phrs.2009.04.014. Epub 2009 May 13. Pharmacol Res. 2009. PMID: 19446027
Atherosclerosis and SBP were the most important determinants of PWV and the effect of ANP was independent of confounding factors. It is concluded that short-term ANP administration in doses to achieve levels approximately threefold the pretreatment ones in normal and mildl …
Atherosclerosis and SBP were the most important determinants of PWV and the effect of ANP was independent of confounding factors. It is conc …
23 results