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Which terms should be used to describe medications used in the treatment of seizure disorders? An ILAE position paper.
Perucca E, French JA, Aljandeel G, Balestrini S, Braga P, Burneo JG, Felli AC, Cross JH, Galanopoulou AS, Jain S, Jiang Y, Kälviäinen R, Lim SH, Meador KJ, Mogal Z, Nabbout R, Sofia F, Somerville E, Sperling MR, Triki C, Trinka E, Walker MC, Wiebe S, Wilmshurst JM, Wirrell E, Yacubian EM, Kapur J. Perucca E, et al. Among authors: kapur j. Epilepsia. 2024 Mar;65(3):533-541. doi: 10.1111/epi.17877. Epub 2024 Jan 27. Epilepsia. 2024. PMID: 38279786 Review.
There was consensus that these medications should be collectively named "antiseizure medications". This term accurately reflects their primarily symptomatic effect against seizures and reduces the possibility of health care practitioners, patients, or caregivers having und …
There was consensus that these medications should be collectively named "antiseizure medications". This term accurately reflects thei …
Drug-Inducible Gene Therapy Effectively Reduces Spontaneous Seizures in Kindled Rats but Creates Off-Target Side Effects in Inhibitory Neurons.
Sullivan KA, Vitko I, Blair K, Gaykema RP, Failor MJ, San Pietro JM, Dey D, Williamson JM, Stornetta RL, Kapur J, Perez-Reyes E. Sullivan KA, et al. Among authors: kapur j. Int J Mol Sci. 2023 Jul 12;24(14):11347. doi: 10.3390/ijms241411347. Int J Mol Sci. 2023. PMID: 37511107 Free PMC article.
Moreover, a common property of antiepileptic drugs is a narrow therapeutic window between seizure control and side effects. Therefore, a long-term goal is to develop drug-inducible gene therapies that can be regulated by clinically relevant drugs. ...
Moreover, a common property of antiepileptic drugs is a narrow therapeutic window between seizure control and side effects. Therefore, a lon …
Chronic neuronal activation leads to elevated lactate dehydrogenase A through the AMP-activated protein kinase/hypoxia-inducible factor-1α hypoxia pathway.
Ksendzovsky A, Bachani M, Altshuler M, Walbridge S, Mortazavi A, Moyer M, Chen C, Fayed I, Steiner J, Edwards N, Inati SK, Jahanipour J, Maric D, Heiss JD, Kapur J, Zaghloul KA. Ksendzovsky A, et al. Among authors: kapur j. Brain Commun. 2022 Dec 1;5(1):fcac298. doi: 10.1093/braincomms/fcac298. eCollection 2023. Brain Commun. 2022. PMID: 36655171 Free PMC article.
In this study, we examine elevations in the lactate dehydrogenase A protein as a long-term cellular adaptation to elevated metabolic demand from chronic neuronal activation. ...Similar to states of hypoxia, this metabolic change occurs through the AMP-activated protein kin …
In this study, we examine elevations in the lactate dehydrogenase A protein as a long-term cellular adaptation to elevated metabolic …
Focal impaired awareness seizures in a rodent model: A functional anatomy.
Adotevi N, Kapur J. Adotevi N, et al. Among authors: kapur j. Epilepsia Open. 2022 Mar;7(1):110-123. doi: 10.1002/epi4.12563. Epub 2021 Dec 17. Epilepsia Open. 2022. PMID: 34822222 Free PMC article.
Many of the seizure-activated neuronal circuits are critical modulators of memory consolidation and long-term stress/depression response. The hijack of these memory and depression regulatory systems by a focal seizure could account for the frequent reports of comorbidities …
Many of the seizure-activated neuronal circuits are critical modulators of memory consolidation and long-term stress/depression respo …
Imaging findings on contrast-enhanced ultrasound, magnetic resonance imaging and hybrid positron emission tomography in Takayasu arteritis: a case report.
Goh Y, Ting E, Kapur J, Dewi M, Sinha AK, Sharma VK. Goh Y, et al. Among authors: kapur j. Med Ultrason. 2020 Nov 18;22(4):485-487. doi: 10.11152/mu-2249. Epub 2019 Dec 19. Med Ultrason. 2020. PMID: 32190860 Free article.
To our knowledge, this is the first case which demonstrates pictorial correlation of arterial wall neovascularity on CEUS with mural edema on magnetic resonance imaging and metabolic activity on positron emission tomography - computed tomography in the same patient. As TA is a ch …
To our knowledge, this is the first case which demonstrates pictorial correlation of arterial wall neovascularity on CEUS with mural edema o …
Neurosteroid-sensitive δ-GABAA receptors: A role in epileptogenesis?
Joshi S, Rajasekaran K, Williamson J, Kapur J. Joshi S, et al. Among authors: kapur j. Epilepsia. 2017 Mar;58(3):494-504. doi: 10.1111/epi.13660. Epub 2017 Jan 18. Epilepsia. 2017. PMID: 28452419 Free PMC article.
Finally, the effects of inhibiting N-methyl-d-aspartate receptors (NMDARs) during SE on the long-term plasticity of delta-GABARs, neurosteroid-induced modulation of tonic current, and epileptogenesis were studied. ...
Finally, the effects of inhibiting N-methyl-d-aspartate receptors (NMDARs) during SE on the long-term plasticity of delta-GABARs, neu …
Infant feeding effects on early neurocognitive development in Asian children.
Cai S, Pang WW, Low YL, Sim LW, Sam SC, Bruntraeger MB, Wong EQ, Fok D, Broekman BF, Singh L, Richmond J, Agarwal P, Qiu A, Saw SM, Yap F, Godfrey KM, Gluckman PD, Chong YS, Meaney MJ, Kramer MS, Rifkin-Graboi A; GUSTO Study Group. Cai S, et al. Am J Clin Nutr. 2015 Feb;101(2):326-36. doi: 10.3945/ajcn.114.095414. Epub 2014 Dec 10. Am J Clin Nutr. 2015. PMID: 25646330 Free article.
OBJECTIVE: We assessed associations between early infant feeding and detailed measures of cognitive development in the first 2 y of life in healthy Asian children born at term. DESIGN: In a prospective cohort study, neurocognitive testing was performed in 408 healthy child …
OBJECTIVE: We assessed associations between early infant feeding and detailed measures of cognitive development in the first 2 y of life in …
Gestational age and neonatal brain microstructure in term born infants: a birth cohort study.
Broekman BF, Wang C, Li Y, Rifkin-Graboi A, Saw SM, Chong YS, Kwek K, Gluckman PD, Fortier MV, Meaney MJ, Qiu A; GUSTO Study Group. Broekman BF, et al. PLoS One. 2014 Dec 23;9(12):e115229. doi: 10.1371/journal.pone.0115229. eCollection 2014. PLoS One. 2014. PMID: 25535959 Free PMC article.
To understand healthy brain development between 37-41 weeks of gestational age, our study assessed the in utero growth of the brain in healthy term born babies with DTI scanning soon after birth. METHODS: A cohort of 93 infants recruited from maternity hospitals in …
To understand healthy brain development between 37-41 weeks of gestational age, our study assessed the in utero growth of the brain in healt …
Impact of transient acute hypoxia on the developing mouse EEG.
Zanelli S, Goodkin HP, Kowalski S, Kapur J. Zanelli S, et al. Among authors: kapur j. Neurobiol Dis. 2014 Aug;68:37-46. doi: 10.1016/j.nbd.2014.03.005. Epub 2014 Mar 15. Neurobiol Dis. 2014. PMID: 24636798 Free PMC article.
Hypoxemic events are common in sick preterm and term infants and represent the most common cause of seizures in the newborn period. ...
Hypoxemic events are common in sick preterm and term infants and represent the most common cause of seizures in the newborn period. . …
Management of asymptomatic cardiac murmurs in term neonates.
Shenvi A, Kapur J, Rasiah SV. Shenvi A, et al. Among authors: kapur j. Pediatr Cardiol. 2013 Aug;34(6):1438-46. doi: 10.1007/s00246-013-0668-6. Epub 2013 Mar 10. Pediatr Cardiol. 2013. PMID: 23475198 Review.
In an asymptomatic term neonate with cardiac murmur, 124 (94 %) units perform pulse oximetry, 100 units (76 %) measure four-limb BP, 36 units (27 %) perform a CXR, and 52 units (39 %) perform an ECG. ...Currently there is wide variation in practice in the management of asy …
In an asymptomatic term neonate with cardiac murmur, 124 (94 %) units perform pulse oximetry, 100 units (76 %) measure four-limb BP, …
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