Biphasic Regulation of Mitogen-Activated Protein Kinase Phosphatase 3 in Hypoxic Colon Cancer Cells.
Kim HS, Kang YH, Lee J, Han SR, Kim DB, Ko H, Park S, Lee MS.
Kim HS, et al. Among authors: kang yh.
Mol Cells. 2021 Oct 31;44(10):710-722. doi: 10.14348/molcells.2021.0093.
Mol Cells. 2021.
PMID: 34711689
Free PMC article.
These findings indicated that MKP-3, induced by HIF-1alpha in hypoxia, negatively regulates HIF-1alpha protein levels and hypoxia-responsive genes. However, we also found that long-term hypoxia ((>)12 h) induced proteasomal degradation of MKP-3 in a lactic acid-dependen …
These findings indicated that MKP-3, induced by HIF-1alpha in hypoxia, negatively regulates HIF-1alpha protein levels and hypoxia-responsive …