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Antagonism of myostatin enhances muscle regeneration during sarcopenia.
Siriett V, Salerno MS, Berry C, Nicholas G, Bower R, Kambadur R, Sharma M. Siriett V, et al. Among authors: kambadur r. Mol Ther. 2007 Aug;15(8):1463-70. doi: 10.1038/sj.mt.6300182. Epub 2007 Jun 5. Mol Ther. 2007. PMID: 17551508 Free article.
The present study specifically tests the therapeutic value of a myostatin antagonist in sarcopenia. We report here that a short-term blockade of myostatin, through stage-specific administration of a myostatin antagonist, significantly enhanced muscle regeneration in aged m …
The present study specifically tests the therapeutic value of a myostatin antagonist in sarcopenia. We report here that a short-term …
Actions of short-term fasting on human skeletal muscle myogenic and atrogenic gene expression.
Larsen AE, Tunstall RJ, Carey KA, Nicholas G, Kambadur R, Crowe TC, Cameron-Smith D. Larsen AE, et al. Among authors: kambadur r. Ann Nutr Metab. 2006;50(5):476-81. doi: 10.1159/000095354. Epub 2006 Aug 24. Ann Nutr Metab. 2006. PMID: 16931880
The coordinated control of these myogenic and atrogenic factors in human skeletal muscle following short-term fasting is currently unknown. METHOD: Healthy adults (n = 6, age 27.6 years) undertook a 40-hour fast. ...CONCLUSIONS: Unlike previous observations in catabolic an …
The coordinated control of these myogenic and atrogenic factors in human skeletal muscle following short-term fasting is currently un …
Prolonged underfeeding of sheep increases myostatin and myogenic regulatory factor Myf-5 in skeletal muscle while IGF-I and myogenin are repressed.
Jeanplong F, Bass JJ, Smith HK, Kirk SP, Kambadur R, Sharma M, Oldham JM. Jeanplong F, et al. Among authors: kambadur r. J Endocrinol. 2003 Mar;176(3):425-37. doi: 10.1677/joe.0.1760425. J Endocrinol. 2003. PMID: 12630927
Subsequently, Myf-5, MyoD, myostatin mRNA and processed myostatin increased, suggesting that satellite cells may have become progressively quiescent. Long-term underfeeding caused muscle necrosis in some animals and IGF-I and MRF expression was increased in these, indicati …
Subsequently, Myf-5, MyoD, myostatin mRNA and processed myostatin increased, suggesting that satellite cells may have become progressively q …
The regulation and action of myostatin as a negative regulator of muscle development during avian embryogenesis.
Amthor H, Huang R, McKinnell I, Christ B, Kambadur R, Sharma M, Patel K. Amthor H, et al. Among authors: kambadur r. Dev Biol. 2002 Nov 15;251(2):241-57. doi: 10.1006/dbio.2002.0812. Dev Biol. 2002. PMID: 12435355 Free article.
Finally, we show that application of Myostatin protein into the developing limb bud results in a down-regulation of Pax-3 and Myf-5, both genes associated with proliferation of myogenic cells; and, furthermore, Myostatin also prevents the expression of MyoD, a gene associated wit …
Finally, we show that application of Myostatin protein into the developing limb bud results in a down-regulation of Pax-3 and Myf-5, both ge …