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Correlated Measurement of Endogenous ATE1 Activity on Native Acceptor Proteins in Tissues and Cultured Cells to Detect Cellular Aging.
Kaji H, Kaji A. Kaji H, et al. Methods Mol Biol. 2023;2620:41-50. doi: 10.1007/978-1-0716-2942-0_6. Methods Mol Biol. 2023. PMID: 37010747
Remarkably, in these assays, we found a close correlation between arginylation and aging, a discovery that we believe has longer-term implications in uncovering the importance of ATE1 in normal biology and disease therapies. ...
Remarkably, in these assays, we found a close correlation between arginylation and aging, a discovery that we believe has longer-term …
Effect of sustained insulin-releasing device made of poly(ethylene glycol) dimethacrylates on retinal function in streptozotocin-induced diabetic rats.
Hoshi A, Nagai N, Daigaku R, Motoyama R, Saijo S, Kaji H, Abe T. Hoshi A, et al. Among authors: kaji h. J Mater Sci Mater Med. 2020 May 27;31(6):52. doi: 10.1007/s10856-020-06392-8. J Mater Sci Mater Med. 2020. PMID: 32462459
In conclusion, the insulin-releasing device attenuated the reduction of retinal function in STZ-induced diabetic conditions for 4 weeks and the efficacy of the device might be partially related to PKC signaling in the retina. The long-term ability to control the blood gluc …
In conclusion, the insulin-releasing device attenuated the reduction of retinal function in STZ-induced diabetic conditions for 4 weeks and …
A drug refillable device for transscleral sustained drug delivery to the retina.
Nagai N, Saijo S, Song Y, Kaji H, Abe T. Nagai N, et al. Among authors: kaji h. Eur J Pharm Biopharm. 2019 Mar;136:184-191. doi: 10.1016/j.ejpb.2019.01.024. Epub 2019 Jan 25. Eur J Pharm Biopharm. 2019. PMID: 30690065
In conclusion, the refillable drug delivery device is a promising tool to administer drugs long-term by reinjection with less invasiveness to intraocular tissues....
In conclusion, the refillable drug delivery device is a promising tool to administer drugs long-term by reinjection with less invasiv …
Long-Term Protection of Genetically Ablated Rabbit Retinal Degeneration by Sustained Transscleral Unoprostone Delivery.
Nagai N, Koyanagi E, Izumida Y, Liu J, Katsuyama A, Kaji H, Nishizawa M, Osumi N, Kondo M, Terasaki H, Mashima Y, Nakazawa T, Abe T. Nagai N, et al. Among authors: kaji h. Invest Ophthalmol Vis Sci. 2016 Dec 1;57(15):6527-6538. doi: 10.1167/iovs.16-20453. Invest Ophthalmol Vis Sci. 2016. PMID: 27918826
PURPOSE: To evaluate the long-term protective effects of transscleral unoprostone (UNO) against retinal degeneration in transgenic (Tg) rabbits (Pro347Leu rhodopsin mutation). ...CONCLUSIONS: In Tg rabbits, URD use slowed the decline of retinal function for more than 32 we …
PURPOSE: To evaluate the long-term protective effects of transscleral unoprostone (UNO) against retinal degeneration in transgenic (T …
Correlated Measurement of Endogenous ATE1 Activity on Native Acceptor Proteins in Tissues and Cultured Cells to Detect Cellular Aging.
Kaji H, Kaji A. Kaji H, et al. Methods Mol Biol. 2015;1337:39-48. doi: 10.1007/978-1-4939-2935-1_6. Methods Mol Biol. 2015. PMID: 26285879
Remarkably, in these assays, we found a close correlation between arginylation and aging, a discovery that we believe has longer-term implications in uncovering the importance of ATE1 in normal biology and disease therapies. ...
Remarkably, in these assays, we found a close correlation between arginylation and aging, a discovery that we believe has longer-term …
Role of plasminogen activator inhibitor-1 in glucocorticoid-induced diabetes and osteopenia in mice.
Tamura Y, Kawao N, Yano M, Okada K, Okumoto K, Chiba Y, Matsuo O, Kaji H. Tamura Y, et al. Among authors: kaji h. Diabetes. 2015 Jun;64(6):2194-206. doi: 10.2337/db14-1192. Epub 2014 Dec 31. Diabetes. 2015. PMID: 25552599
Long-term use of glucocorticoids (GCs) causes numerous adverse effects, including glucose/lipid abnormalities, osteoporosis, and muscle wasting. ...
Long-term use of glucocorticoids (GCs) causes numerous adverse effects, including glucose/lipid abnormalities, osteoporosis, and musc …
Ribosome recycling: An essential process of protein synthesis.
Kiel MC, Kaji H, Kaji A. Kiel MC, et al. Among authors: kaji h. Biochem Mol Biol Educ. 2007 Jan;35(1):40-4. doi: 10.1002/bmb.6. Biochem Mol Biol Educ. 2007. PMID: 21591054 Free article.
It is only during the fourth step of translation that ribosomes are ultimately released from the mRNA, split into subunits, and are free to bind new mRNA, thus the term "ribosome recycling." This step is essential to the viability of cells. ...
It is only during the fourth step of translation that ribosomes are ultimately released from the mRNA, split into subunits, and are free to …
The usefulness of bone metabolic indices for the prediction of changes in bone mineral density after parathyroidectomy in patients with primary hyperparathyroidism.
Kaji H, Nomura R, Yamauchi M, Chihara K, Sugimoto T. Kaji H, et al. Horm Metab Res. 2006 Jun;38(6):411-6. doi: 10.1055/s-2006-944533. Horm Metab Res. 2006. PMID: 16823724
The measurement of urinary Dpd would be useful for predicting long-term changes in BMD at radial and lumbar spine after PTX than other bone metabolic indices....
The measurement of urinary Dpd would be useful for predicting long-term changes in BMD at radial and lumbar spine after PTX than othe …
12 results