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Regeneration of Nonhuman Primate Hearts With Human Induced Pluripotent Stem Cell-Derived Cardiac Spheroids.
Kobayashi H, Tohyama S, Ichimura H, Ohashi N, Chino S, Soma Y, Tani H, Tanaka Y, Yang X, Shiba N, Kadota S, Haga K, Moriwaki T, Morita-Umei Y, Umei TC, Sekine O, Kishino Y, Kanazawa H, Kawagishi H, Yamada M, Narita K, Naito T, Seto T, Kuwahara K, Shiba Y, Fukuda K. Kobayashi H, et al. Among authors: kadota s. Circulation. 2024 Apr 26. doi: 10.1161/CIRCULATIONAHA.123.064876. Online ahead of print. Circulation. 2024. PMID: 38666382
Transplantation of increased dose of CMs resulted in significantly greater engraftment and long-term contractile benefits (fractional shortening at 12 weeks after transplantation: 22.51.0%; 16.61.1%; P<0.01, left ventricular ejection fraction at 12 weeks after transplan …
Transplantation of increased dose of CMs resulted in significantly greater engraftment and long-term contractile benefits (fractional …
Mature human induced pluripotent stem cell-derived cardiomyocytes promote angiogenesis through alpha-B crystallin.
Tanaka Y, Kadota S, Zhao J, Kobayashi H, Okano S, Izumi M, Honda Y, Ichimura H, Shiba N, Uemura T, Wada Y, Chuma S, Nakada T, Tohyama S, Fukuda K, Yamada M, Seto T, Kuwahara K, Shiba Y. Tanaka Y, et al. Among authors: kadota s. Stem Cell Res Ther. 2023 Sep 7;14(1):240. doi: 10.1186/s13287-023-03468-4. Stem Cell Res Ther. 2023. PMID: 37679796 Free PMC article.
Furthermore, CRYAB overexpression enhanced angiogenesis in the D28-CM grafts at 4 weeks post-transplantation. CONCLUSIONS: Long-term cultured mature hiPSC-CMs promoted engraftment, maturation and angiogenesis post-transplantation in infarcted rat hearts. CRYAB, which was h …
Furthermore, CRYAB overexpression enhanced angiogenesis in the D28-CM grafts at 4 weeks post-transplantation. CONCLUSIONS: Long-term …
Complementary mRNA expression of enzymes producing nitric oxide and prostaglandin in ductus arteriosus with respect to their role in maintaining patency.
Yamana R, Kadota S, Ishii K, Suzuki T, Miyazaki Y, Tanaka K, Usami M, Takizawa T. Yamana R, et al. Among authors: kadota s. Congenit Anom (Kyoto). 2023 Mar;63(2):47-51. doi: 10.1111/cga.12505. Epub 2023 Jan 4. Congenit Anom (Kyoto). 2023. PMID: 36573317
mRNA expression of molecules related to the activity of nitric oxide or prostaglandin E2, the critical regulators maintaining the ductus arteriosus patency, was examined in rat ductus arteriosus at preterm (days 18.5 and 19.5 of pregnancy) and near term (days 20.5 and 21.5 …
mRNA expression of molecules related to the activity of nitric oxide or prostaglandin E2, the critical regulators maintaining the ductus art …
The association between post-load low insulin level and high mortality rates in patients with no previous diagnosis of diabetes mellitus.
Kadota S, Matsuda M, Izuhara M, Baba O, Mitsuoka H, Shioji K, Uegaito T. Kadota S, et al. Int J Cardiol. 2011 Apr 1;148(1):59-63. doi: 10.1016/j.ijcard.2009.10.024. Epub 2009 Nov 24. Int J Cardiol. 2011. PMID: 19939479
BACKGROUND: Hyperinsulinemia and insulin resistance have been proposed as having a causal role in pathogenesis of atherosclerosis; however, the relationship between post-load insulin levels and long-term survival is not clear. We investigated whether post-load insulin resp …
BACKGROUND: Hyperinsulinemia and insulin resistance have been proposed as having a causal role in pathogenesis of atherosclerosis; however, …
Long-term effects of early statin therapy for patients with acute myocardial infarction treated with stent implantation.
Kadota S, Matsuda M, Izuhara M, Baba O, Moriwaki S, Shioji K, Takeuchi Y, Uegaito T. Kadota S, et al. J Cardiol. 2008 Jun;51(3):171-8. doi: 10.1016/j.jjcc.2008.02.003. Epub 2008 Apr 18. J Cardiol. 2008. PMID: 18522792 Free article.
OBJECTIVES: Statins are widely administered to patients with acute myocardial infarction (AMI), but knowledge of the effects of early statin therapy on the long-term mortality of AMI patients after stent implantation is still limited, especially for beyond low-density lipo …
OBJECTIVES: Statins are widely administered to patients with acute myocardial infarction (AMI), but knowledge of the effects of early statin …
Stringent requirement for the C protein of wild-type measles virus for growth both in vitro and in macaques.
Takeuchi K, Takeda M, Miyajima N, Ami Y, Nagata N, Suzaki Y, Shahnewaz J, Kadota S, Nagata K. Takeuchi K, et al. Among authors: kadota s. J Virol. 2005 Jun;79(12):7838-44. doi: 10.1128/JVI.79.12.7838-7844.2005. J Virol. 2005. PMID: 15919937 Free PMC article.
Enhanced green fluorescent protein-expressing wtMV(C-) consistently induced late-stage cell rounding and cell death in the presence of a fusion-inhibiting peptide, suggesting that the C protein can prevent cell death and is required for long-term MV infection. Neutralizing …
Enhanced green fluorescent protein-expressing wtMV(C-) consistently induced late-stage cell rounding and cell death in the presence of a fus …
[Ameliorating effects of dan-shen and its major ingredient calcium/magnesium lithospermate B on cognitive deficiencies in senescence-accelerated mouse].
Nomura Y, Arima T, Namba T, Hattori M, Kadota S. Nomura Y, et al. Among authors: kadota s. Nihon Yakurigaku Zasshi. 1997 Oct;110 Suppl 1:142P-147P. doi: 10.1254/fpj.110.supplement_142. Nihon Yakurigaku Zasshi. 1997. PMID: 9503422 Japanese.
Effect of the long-term treatment with a Dan-Shen (Salviae miltiorrhizae radix) methanol extract (DME) or its major ingredient lithospermate B (LSB) on memory and learning in scenescence-accelerated mouse (SAM) was investigated by means of Morris's water maze task. ...
Effect of the long-term treatment with a Dan-Shen (Salviae miltiorrhizae radix) methanol extract (DME) or its major ingredient lithos …