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Cardiac troponin I as predictor for cardiac and other mortality in the German randomized lung cancer screening trial (LUSI).
Cortés-Ibáñez FO, Johnson T, Mascalchi M, Katzke V, Delorme S, Kaaks R. Cortés-Ibáñez FO, et al. Among authors: kaaks r. Sci Rep. 2024 Mar 26;14(1):7197. doi: 10.1038/s41598-024-57889-z. Sci Rep. 2024. PMID: 38531926 Free PMC article.
Our findings show that cTnI may be of use for identifying individuals at elevated risk specifically of short-term cardiac mortality in the context of LC screening....
Our findings show that cTnI may be of use for identifying individuals at elevated risk specifically of short-term cardiac mortality i …
Serum-based biomarkers associated with lung cancer risk and cause-specific mortality in the German randomized Lung Cancer Screening Intervention (LUSI) trial.
Cortés-Ibáñez FO, Johnson T, Mascalchi M, Katzke V, Delorme S, Kaaks R. Cortés-Ibáñez FO, et al. Among authors: kaaks r. Transl Lung Cancer Res. 2023 Dec 26;12(12):2460-2475. doi: 10.21037/tlcr-23-548. Epub 2023 Dec 22. Transl Lung Cancer Res. 2023. PMID: 38205209 Free PMC article.
CONCLUSIONS: Serum GDF-15 and IL-6 may be useful indicators for estimating risks for LC and competing mortality among long-term smokers participating in LC screening, to optimize LC screening strategies....
CONCLUSIONS: Serum GDF-15 and IL-6 may be useful indicators for estimating risks for LC and competing mortality among long-term smoke …
A genome-wide gene-based gene-environment interaction study of breast cancer in more than 90,000 women.
Wang X, Chen H, Middha Kapoor P, Su YR, Bolla MK, Dennis J, Dunning AM, Lush M, Wang Q, Michailidou K, Pharoah PDP, Hopper JL, Southey MC, Koutros S, Beane Freeman LE, Stone J, Rennert G, Shibli R, Murphy RA, Aronson K, Guénel P, Truong T, Teras LR, Hodge JM, Canzian F, Kaaks R, Brenner H, Arndt V, Hoppe R, Lo WY, Behrens S, Mannermaa A, Kosma VM, Jung A, Becher H, Giles GG, Haiman CA, Maskarinec G, Scott C, Winham S, Simard J, Goldberg MS, Zheng W, Long J, Troester MA, Love MI, Peng C, Tamimi R, Eliassen H, García-Closas M, Figueroa J, Ahearn T, Yang R, Evans DG, Howell A, Hall P, Czene K, Wolk A, Sandler DP, Taylor JA, Swerdlow AJ, Orr N, Lacey JV, Wang S, Olsson H, Easton DF, Milne RL, Hsu L, Kraft P, Chang-Claude J, Lindström S. Wang X, et al. Among authors: kaaks r. Cancer Res Commun. 2022 Apr;2(4):211-219. doi: 10.1158/2767-9764.CRC-21-0119. Epub 2022 Apr 8. Cancer Res Commun. 2022. PMID: 36303815 Free PMC article.
The strongest interaction observed was between the predicted expression of the C13orf45 gene and age at first full-term pregnancy (P(GXE)=4.4410(-6)). CONCLUSION: In this transcriptome-informed genome-wide gene-environment interaction study of breast cancer, we found no st …
The strongest interaction observed was between the predicted expression of the C13orf45 gene and age at first full-term pregnancy (P( …
Lung function impairment in the German Lung Cancer Screening Intervention Study (LUSI): prevalence, symptoms, and associations with lung cancer risk, tumor histology and all-cause mortality.
Kaaks R, Christodoulou E, Motsch E, Katzke V, Wielpütz MO, Kauczor HU, Heussel CP, Eichinger M, Delorme S. Kaaks R, et al. Transl Lung Cancer Res. 2022 Sep;11(9):1896-1911. doi: 10.21037/tlcr-22-63. Transl Lung Cancer Res. 2022. PMID: 36248328 Free PMC article.
METHODS: Spirometry was performed in the CT screening arm (n=2,029) of the German Lung Cancer Screening Intervention Study (LUSI)-a trial examining the effects of annual CT screening on lung cancer mortality, in 50-69-year-old long-term smokers. Participants were classifie …
METHODS: Spirometry was performed in the CT screening arm (n=2,029) of the German Lung Cancer Screening Intervention Study (LUSI)-a trial ex …
Anti-cancer therapy is associated with long-term epigenomic changes in childhood cancer survivors.
Robinson N, Casement J, Gunter MJ, Huybrechts I, Agudo A, Barranco MR, Eichelmann F, Johnson T, Kaaks R, Pala V, Panico S, Sandanger TM, Schultze MB, Travis RC, Tumino R, Vineis P, Weiderpass E, Skinner R, Sharp L, McKay JA, Strathdee G. Robinson N, et al. Among authors: kaaks r. Br J Cancer. 2022 Jul;127(2):288-300. doi: 10.1038/s41416-022-01792-9. Epub 2022 Mar 30. Br J Cancer. 2022. PMID: 35354948 Free PMC article.
We investigated the hypothesis that anti-cancer treatments are associated with long-term DNA methylation changes that could be key drivers of adverse late health effects. ...CONCLUSIONS: These novel methylation changes could serve as biomarkers for assessing normal cell to …
We investigated the hypothesis that anti-cancer treatments are associated with long-term DNA methylation changes that could be key dr …
The relationship between blood pressure and risk of renal cell carcinoma.
Alcala K, Mariosa D, Smith-Byrne K, Nasrollahzadeh Nesheli D, Carreras-Torres R, Ardanaz Aicua E, Bondonno NP, Bonet C, Brunström M, Bueno-de-Mesquita B, Chirlaque MD, Christakoudi S, Heath AK, Kaaks R, Katzke V, Krogh V, Ljungberg B, Martin RM, May A, Melander O, Palli D, Rodriguez-Barranco M, Sacerdote C, Stocks T, Tjønneland A, Travis RC, Vermeulen R, Chanock S, Purdue M, Weiderpass E, Muller D, Brennan P, Johansson M. Alcala K, et al. Among authors: kaaks r. Int J Epidemiol. 2022 Aug 10;51(4):1317-1327. doi: 10.1093/ije/dyac042. Int J Epidemiol. 2022. PMID: 35312764 Free PMC article.
RESULTS: In the univariable analysis, we observed clear positive associations with RCC risk for both diastolic and SBP when measured 5 years before diagnosis and suggestive evidence for a stronger risk association in the year leading up to diagnosis. In mutually adjusted analysis …
RESULTS: In the univariable analysis, we observed clear positive associations with RCC risk for both diastolic and SBP when measured 5 years …
Short- and long-term reproducibility of the COMET assay for measuring DNA damage biomarkers in frozen blood samples of the EPIC-Heidelberg cohort.
Bankoglu EE, Mukama T, Katzke V, Stipp F, Johnson T, Kühn T, Seyfried F, Godschalk R, Collins A, Kaaks R, Stopper H. Bankoglu EE, et al. Among authors: kaaks r. Mutat Res Genet Toxicol Environ Mutagen. 2022 Feb-Mar;874-875:503442. doi: 10.1016/j.mrgentox.2022.503442. Epub 2022 Jan 12. Mutat Res Genet Toxicol Environ Mutagen. 2022. PMID: 35151425
Serum markers of biological ageing provide long-term prediction of life expectancy-a longitudinal analysis in middle-aged and older German adults.
Srour B, Hynes LC, Johnson T, Kühn T, Katzke VA, Kaaks R. Srour B, et al. Among authors: kaaks r. Age Ageing. 2022 Feb 2;51(2):afab271. doi: 10.1093/ageing/afab271. Age Ageing. 2022. PMID: 35150586
We investigated whether a pre-selected panel of five serum markers of biological ageing could improve predicting the long-term mortality risk and LE in middle-aged and older women and men. ...CONCLUSIONS: serum markers of ageing are potentially strong predictors for long- …
We investigated whether a pre-selected panel of five serum markers of biological ageing could improve predicting the long-term mortal …
Long-term weight change and risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.
Ellingjord-Dale M, Christakoudi S, Weiderpass E, Panico S, Dossus L, Olsen A, Tjønneland A, Kaaks R, Schulze MB, Masala G, Gram IT, Skeie G, Rosendahl AH, Sund M, Key T, Ferrari P, Gunter M, Heath AK, Tsilidis KK, Riboli E; additional authors. Ellingjord-Dale M, et al. Among authors: kaaks r. Int J Epidemiol. 2022 Jan 6;50(6):1914-1926. doi: 10.1093/ije/dyab032. Epub 2021 Mar 23. Int J Epidemiol. 2022. PMID: 34999853 Free PMC article.
BACKGROUND: The role of obesity and weight change in breast-cancer development is complex and incompletely understood. We investigated long-term weight change and breast-cancer risk by body mass index (BMI) at age 20 years, menopausal status, hormone replacement therapy (H …
BACKGROUND: The role of obesity and weight change in breast-cancer development is complex and incompletely understood. We investigated long- …
Lifetime alcohol intake, drinking patterns over time and risk of stomach cancer: A pooled analysis of data from two prospective cohort studies.
Jayasekara H, MacInnis RJ, Lujan-Barroso L, Mayen-Chacon AL, Cross AJ, Wallner B, Palli D, Ricceri F, Pala V, Panico S, Tumino R, Kühn T, Kaaks R, Tsilidis K, Sánchez MJ, Amiano P, Ardanaz E, Chirlaque López MD, Merino S, Rothwell JA, Boutron-Ruault MC, Severi G, Sternby H, Sonestedt E, Bueno-de-Mesquita B, Boeing H, Travis R, Sandanger TM, Trichopoulou A, Karakatsani A, Peppa E, Tjønneland A, Yang Y, Hodge AM, Mitchell H, Haydon A, Room R, Hopper JL, Weiderpass E, Gunter MJ, Riboli E, Giles GG, Milne RL, Agudo A, English DR, Ferrari P. Jayasekara H, et al. Among authors: kaaks r. Int J Cancer. 2021 Jun 1;148(11):2759-2773. doi: 10.1002/ijc.33504. Epub 2021 Feb 22. Int J Cancer. 2021. PMID: 33554339 Free PMC article.
Alcohol consumption is causally linked to several cancers but the evidence for stomach cancer is inconclusive. In our study, the association between long-term alcohol intake and risk of stomach cancer and its subtypes was evaluated. ...
Alcohol consumption is causally linked to several cancers but the evidence for stomach cancer is inconclusive. In our study, the association …
64 results