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2002 1
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16 results

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Page 1
Characterizing post-branching nephrogenesis in the neonatal rabbit.
Schuh MP, Yarlagadda S, Alkhudairy L, Preusse K, Kopan R. Schuh MP, et al. Sci Rep. 2023 Nov 6;13(1):19234. doi: 10.1038/s41598-023-46624-9. Sci Rep. 2023. PMID: 37932368 Free PMC article.
Human nephrogenesis ends prior to birth in term infants (34-36 week gestation), with most (60%) nephrons forming in late gestation in two post-branching nephrogenesis (PBN) periods: arcading and lateral branch nephrogenesis. ...We performed morphologic and immunohis …
Human nephrogenesis ends prior to birth in term infants (34-36 week gestation), with most (60%) nephrons forming in late gesta …
Neonatal Immune Responses to Respiratory Viruses.
Eddens T, Parks OB, Williams JV. Eddens T, et al. Front Immunol. 2022 Apr 14;13:863149. doi: 10.3389/fimmu.2022.863149. eCollection 2022. Front Immunol. 2022. PMID: 35493465 Free PMC article. Review.
These early life infections present a formidable immunologic challenge with a number of possibly conflicting goals: simultaneously eliminate the acute pathogen, preserve the primary gas-exchange function of the lung parenchyma in a developing lung, and limit long-term sequ …
These early life infections present a formidable immunologic challenge with a number of possibly conflicting goals: simultaneously eliminate …
ST2 Is a Biomarker of Pediatric Pulmonary Arterial Hypertension Severity and Clinical Worsening.
Griffiths M, Yang J, Simpson CE, Vaidya D, Nies M, Brandal S, Damico R, Ivy DD, Austin ED, Pauciulo MW, Lutz KA, Rosenzweig EB, Hirsch R, Yung D, Nichols WC, Everett AD. Griffiths M, et al. Chest. 2021 Jul;160(1):297-306. doi: 10.1016/j.chest.2021.01.085. Epub 2021 Feb 18. Chest. 2021. PMID: 33609516 Free PMC article.
Clinical mortality models (the Registry to Evaluate Early and Long-Term PAH Disease Management [REVEAL] score) with and without ST2 were used to predict worsening outcomes and compared. ...
Clinical mortality models (the Registry to Evaluate Early and Long-Term PAH Disease Management [REVEAL] score) with and without ST2 w …
The pulmonary metatranscriptome prior to pediatric HCT identifies post-HCT lung injury.
Zinter MS, Lindemans CA, Versluys BA, Mayday MY, Sunshine S, Reyes G, Sirota M, Sapru A, Matthay MA, Kharbanda S, Dvorak CC, Boelens JJ, DeRisi JL. Zinter MS, et al. Blood. 2021 Mar 25;137(12):1679-1689. doi: 10.1182/blood.2020009246. Blood. 2021. PMID: 33512420 Free PMC article.
Lung injury after pediatric allogeneic hematopoietic cell transplantation (HCT) is a common and disastrous complication that threatens long-term survival. To develop strategies to prevent lung injury, novel tools are needed to comprehensively assess lung health in HCT cand …
Lung injury after pediatric allogeneic hematopoietic cell transplantation (HCT) is a common and disastrous complication that threatens long- …
Epigenetic Suppression of Transgenic T-cell Receptor Expression via Gamma-Retroviral Vector Methylation in Adoptive Cell Transfer Therapy.
Nowicki TS, Farrell C, Morselli M, Rubbi L, Campbell KM, Macabali MH, Berent-Maoz B, Comin-Anduix B, Pellegrini M, Ribas A. Nowicki TS, et al. Cancer Discov. 2020 Nov;10(11):1645-1653. doi: 10.1158/2159-8290.CD-20-0300. Epub 2020 Jul 22. Cancer Discov. 2020. PMID: 32699033 Free PMC article.
Transgenic T-cell receptor (TCR) adoptive cell therapies recognizing tumor antigens are associated with robust initial response rates, but frequent disease relapse. This usually occurs in the setting of poor long-term persistence of cells expressing the transgenic TCR, gen …
Transgenic T-cell receptor (TCR) adoptive cell therapies recognizing tumor antigens are associated with robust initial response rates, but f …
Human 3D cellular model of hypoxic brain injury of prematurity.
Pașca AM, Park JY, Shin HW, Qi Q, Revah O, Krasnoff R, O'Hara R, Willsey AJ, Palmer TD, Pașca SP. Pașca AM, et al. Nat Med. 2019 May;25(5):784-791. doi: 10.1038/s41591-019-0436-0. Epub 2019 May 6. Nat Med. 2019. PMID: 31061540 Free PMC article.
Owing to recent medical and technological advances in neonatal care, infants born extremely premature have increased survival rates(1,2). After birth, these infants are at high risk of hypoxic episodes because of lung immaturity, hypotension and lack of cerebral-flow regul …
Owing to recent medical and technological advances in neonatal care, infants born extremely premature have increased survival rates(1,2). Af …
Temporal dynamics of liver mitochondrial protein acetylation and succinylation and metabolites due to high fat diet and/or excess glucose or fructose.
Meyer JG, Softic S, Basisty N, Rardin MJ, Verdin E, Gibson BW, Ilkayeva O, Newgard CB, Kahn CR, Schilling B. Meyer JG, et al. PLoS One. 2018 Dec 26;13(12):e0208973. doi: 10.1371/journal.pone.0208973. eCollection 2018. PLoS One. 2018. PMID: 30586434 Free PMC article.
To connect diet and molecular changes, here we performed short- and long-term feeding of mice with standard chow diet (SCD) and high-fat diet (HFD), with or without glucose or fructose supplementation, and quantified liver metabolites, 861 proteins, and 1,815 protein level …
To connect diet and molecular changes, here we performed short- and long-term feeding of mice with standard chow diet (SCD) and high- …
Reactive astrocyte COX2-PGE2 production inhibits oligodendrocyte maturation in neonatal white matter injury.
Shiow LR, Favrais G, Schirmer L, Schang AL, Cipriani S, Andres C, Wright JN, Nobuta H, Fleiss B, Gressens P, Rowitch DH. Shiow LR, et al. Glia. 2017 Dec;65(12):2024-2037. doi: 10.1002/glia.23212. Epub 2017 Aug 30. Glia. 2017. PMID: 28856805 Free PMC article.
Here, we investigated downstream effects of pro-inflammatory IL-1beta to induce cyclooxygenase-2 (COX2) and prostaglandin E2 (PGE2) production in white matter. First, we assessed COX2 expression in human fetal brain and term neonatal brain affected by hypoxic-ischemic ence …
Here, we investigated downstream effects of pro-inflammatory IL-1beta to induce cyclooxygenase-2 (COX2) and prostaglandin E2 (PGE2) producti …
STIM1 and STIM2 cooperatively regulate mouse neutrophil store-operated calcium entry and cytokine production.
Clemens RA, Chong J, Grimes D, Hu Y, Lowell CA. Clemens RA, et al. Blood. 2017 Sep 28;130(13):1565-1577. doi: 10.1182/blood-2016-11-751230. Epub 2017 Jul 19. Blood. 2017. PMID: 28724541 Free PMC article.
Reactive oxygen species (ROS) production, degranulation, and phagocytosis are normal in the absence of STIM2, suggesting STIM1 is the dominant calcium sensor required for classical short-term neutrophil responses. However, neutrophil cytokine production required STIM2, but …
Reactive oxygen species (ROS) production, degranulation, and phagocytosis are normal in the absence of STIM2, suggesting STIM1 is the domina …
Urinary tract infections in the infant.
Arshad M, Seed PC. Arshad M, et al. Clin Perinatol. 2015 Mar;42(1):17-28, vii. doi: 10.1016/j.clp.2014.10.003. Epub 2014 Dec 24. Clin Perinatol. 2015. PMID: 25677994 Free PMC article. Review.
Early recognition and initiation of adequate therapy for UTI is important to reduce the risk of long-term renal scarring. Ampicillin and gentamicin are traditionally the empiric treatment of choice; however, local antibiotic resistance patterns should be considered. Matern …
Early recognition and initiation of adequate therapy for UTI is important to reduce the risk of long-term renal scarring. Ampicillin …
16 results