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Public Health Responses to CBRN Terrorism in the Middle East and North Africa.
Mani Z, Plummer V, Kuhn L, Khorram-Manesh A, Tin D, Goniewicz K. Mani Z, et al. Among authors: kuhn l. Disaster Med Public Health Prep. 2024 Apr 15;18:e87. doi: 10.1017/dmp.2024.73. Disaster Med Public Health Prep. 2024. PMID: 38618924
These findings indicate the extensive impact of CBRN terrorism on healthcare infrastructures, highlighting the challenges in providing immediate health responses and the necessity for long-term recovery strategies. CONCLUSIONS: The study underscores the need for improved h …
These findings indicate the extensive impact of CBRN terrorism on healthcare infrastructures, highlighting the challenges in providing immed …
Effective early antiretroviral therapy in perinatal-HIV infection reduces subsequent plasma inflammatory profile.
Nguyen AN, Plotkin AL, Odumade OA, De Armas L, Pahwa S, Morrocchi E, Cotugno N, Rossi P, Foster C, Domínguez-Rodríguez S, Tagarro A, Syphurs C, Diray-Arce J, Fatou B, Ozonoff A, Levy O, Palma P, Smolen KK; on the behalf of the EPIICAL Consortium. Nguyen AN, et al. Pediatr Res. 2023 Nov;94(5):1667-1674. doi: 10.1038/s41390-023-02669-0. Epub 2023 Jun 13. Pediatr Res. 2023. PMID: 37308683
BACKGROUND: The long-term immunologic effects of antiretroviral therapy (ART) in children with perinatally-acquired HIV (PHIV) have not been fully elucidated. ...Our results suggest that effective ART treatment initiated within 6 months of life in PHIV participants dampens …
BACKGROUND: The long-term immunologic effects of antiretroviral therapy (ART) in children with perinatally-acquired HIV (PHIV) have n …
Impact of antenatal antiretroviral drug exposure on the growth of children who are HIV-exposed uninfected: the national South African Prevention of Mother to Child Evaluation cohort study.
Ramokolo V, Kuhn L, Lombard C, Jackson D, Goga AE. Ramokolo V, et al. Among authors: kuhn l. BMC Infect Dis. 2022 Dec 6;22(1):908. doi: 10.1186/s12879-022-07847-9. BMC Infect Dis. 2022. PMID: 36474212 Free PMC article.
RESULTS: Among 2526 CHEU, 617 (24.4%) were exposed to ART since -pregnancy (pre-conception ART), 782 (31.0%) to ART commencing post-conception, 879 (34.8%) to maternal ARV prophylaxis (Azidothymidine (AZT)), and 248 (9.8%) had no ARV exposure. In unadjusted analyses, preterm b …
RESULTS: Among 2526 CHEU, 617 (24.4%) were exposed to ART since -pregnancy (pre-conception ART), 782 (31.0%) to ART commencing post-concepti …
RelB contributes to the survival, migration and lymphomagenesis of B cells with constitutively active CD40 signaling.
Kuhn LB, Valentin S, Stojanovic K, Strobl DC, Babushku T, Wang Y, Rambold U, Scheffler L, Grath S, John-Robbert D, Blum H, Feuchtinger A, Blutke A, Weih F, Kitamura D, Rad R, Strobl LJ, Zimber-Strobl U. Kuhn LB, et al. Front Immunol. 2022 Aug 30;13:913275. doi: 10.3389/fimmu.2022.913275. eCollection 2022. Front Immunol. 2022. PMID: 36110848 Free PMC article.
RNA-Seq-analysis revealed that several genes involved in B-cell migration, survival, proliferation and cytokine signaling govern the transcriptional differences modulated by the ablation of RelB in long-term CD40-stimulated B cells. Inactivation of RelB did not abrogate ly …
RNA-Seq-analysis revealed that several genes involved in B-cell migration, survival, proliferation and cytokine signaling govern the transcr …
Evaluation of submaximal endurance in young children living with HIV.
Potterton J, Strehlau R, Shiau S, Comley-White N, Kuhn L, Yin M, Arpadi S. Potterton J, et al. Among authors: kuhn l. S Afr J Physiother. 2022 Feb 21;78(1):1613. doi: 10.4102/sajp.v78i1.1613. eCollection 2022. S Afr J Physiother. 2022. PMID: 35281781 Free PMC article.
BACKGROUND: There is growing concern about the long-term sequelae [a condition which is the consequence of a previous disease or injury] of perinatally acquired human immunodeficiency virus (HIV). ...
BACKGROUND: There is growing concern about the long-term sequelae [a condition which is the consequence of a previous disease or inju …
Evaluation of mortality following paclitaxel drug-coated balloon angioplasty of femoropopliteal lesions in patients with ulcerations and gangrene - a single center experience.
Böhme T, Noory E, Beschorner U, Jacques B, Bürgelin K, Macharzina R, Kuhn LM, Nührenberg T, Neumann FJ, Zeller T. Böhme T, et al. Among authors: kuhn lm. Vasa. 2021 Feb;50(2):132-138. doi: 10.1024/0301-1526/a000910. Epub 2020 Oct 29. Vasa. 2021. PMID: 33118425
Background: A recent meta-analysis of randomized controlled trials suggested an increased long-term mortality risk following femoropopliteal angioplasty using paclitaxel coated devices. To assess the long-term mortality after paclitaxel drug-coated (DCB) and uncoate …
Background: A recent meta-analysis of randomized controlled trials suggested an increased long-term mortality risk following femoropo …
Cost-Effectiveness of Preemptive Switching to Efavirenz-Based Antiretroviral Therapy for Children With Human Immunodeficiency Virus.
Desmonde S, Frank SC, Coovadia A, Dahourou DL, Hou T, Abrams EJ, Amorissani-Folquet M, Walensky RP, Strehlau R, Penazzato M, Freedberg KA, Kuhn L, Leroy V, Ciaranello AL. Desmonde S, et al. Among authors: kuhn l. Open Forum Infect Dis. 2019 Jun 11;6(7):ofz276. doi: 10.1093/ofid/ofz276. eCollection 2019 Jul. Open Forum Infect Dis. 2019. PMID: 31334298 Free PMC article.
CONCLUSION: For children 3 years old and virologically suppressed by LPV/r-based ART, preemptive switching to EFV can improve long-term clinical outcomes and be cost saving. CLINICAL TRIALS REGISTRATION: NCT01127204....
CONCLUSION: For children 3 years old and virologically suppressed by LPV/r-based ART, preemptive switching to EFV can improve long-term …
Distinct epigenetic profiles in children with perinatally-acquired HIV on antiretroviral therapy.
Shiau S, Strehlau R, Wang S, Violari A, Do C, Patel F, Liberty A, Krupska I, Arpadi SM, Foca M, Coovadia A, Abrams EJ, Tycko B, Terry MB, Kuhn L. Shiau S, et al. Among authors: kuhn l. Sci Rep. 2019 Jul 19;9(1):10495. doi: 10.1038/s41598-019-46930-1. Sci Rep. 2019. PMID: 31324826 Free PMC article.
Perinatally-acquired HIV has persistent effects on long-term health outcomes, even after early treatment. We hypothesize that epigenetic indicators, such as DNA methylation, may elucidate cellular processes that explain these effects. ...
Perinatally-acquired HIV has persistent effects on long-term health outcomes, even after early treatment. We hypothesize that epigene …
Mitochondrial Impairment in Well-Suppressed Children with Perinatal HIV-Infection on Antiretroviral Therapy.
Shen J, Liberty A, Shiau S, Strehlau R, Pierson S, Patel F, Wang L, Burke M, Violari A, Coovadia A, Abrams EJ, Arpadi S, Foca M, Kuhn L. Shen J, et al. Among authors: kuhn l. AIDS Res Hum Retroviruses. 2020 Jan;36(1):27-38. doi: 10.1089/AID.2018.0182. Epub 2019 Jul 15. AIDS Res Hum Retroviruses. 2020. PMID: 31179720 Free PMC article.
Whether mitochondrial function recovers with early initiation of ART and sustained viral suppression on long-term ART is unclear. In this study, we evaluate mitochondrial markers in well-suppressed perinatally HIV-infected children initiated on ART early in life. ...
Whether mitochondrial function recovers with early initiation of ART and sustained viral suppression on long-term ART is unclear. In …
Patient-reported complications related to peripherally inserted central catheters: a multicentre prospective cohort study.
Krein SL, Saint S, Trautner BW, Kuhn L, Colozzi J, Ratz D, Lescinskas E, Chopra V. Krein SL, et al. Among authors: kuhn l. BMJ Qual Saf. 2019 Jul;28(7):574-581. doi: 10.1136/bmjqs-2018-008726. Epub 2019 Jan 25. BMJ Qual Saf. 2019. PMID: 30683751 Free PMC article.
RESULTS: Of the 438 patients in the analytic cohort (91.4% of those consented), two-thirds were male with a mean age of 56 years. The most common reason for PICC placement was long-term antibiotic therapy (43.4%). During the 70-day follow-up period, 61.4% of patients repor …
RESULTS: Of the 438 patients in the analytic cohort (91.4% of those consented), two-thirds were male with a mean age of 56 years. The most c …
49 results