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Short-term stimulations of the entopeduncular nucleus induce cerebellar changes of c-Fos expression in an animal model of paroxysmal dystonia.
Lüttig A, Perl S, Zetsche M, Richter F, Franz D, Heerdegen M, Köhling R, Richter A. Lüttig A, et al. Among authors: kohling r. Brain Res. 2024 Jan 15;1823:148672. doi: 10.1016/j.brainres.2023.148672. Epub 2023 Nov 11. Brain Res. 2024. PMID: 37956748 Free article.
Insights into the mechanisms of DBS in animal models of dystonia can be helpful for optimization of DBS and add-on therapeutics. We recently found that short-term EPN-DBS with 130 Hz (50 A, 60 s) for 3 h improved dystonia in dt(sz) hamsters and reduced spontaneous excitato …
Insights into the mechanisms of DBS in animal models of dystonia can be helpful for optimization of DBS and add-on therapeutics. We recently …
GluN2B inhibition rescues impaired potentiation and epileptogenicity at associational-commissural CA3 synapses in a model of anti-NMDAR encephalitis.
Küpper M, Porath K, Sellmann T, Bien CG, Köhling R, Kirschstein T. Küpper M, et al. Among authors: kohling r. Neurosci Lett. 2023 Jan 31;795:137031. doi: 10.1016/j.neulet.2022.137031. Epub 2022 Dec 24. Neurosci Lett. 2023. PMID: 36574811
Anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis is an autoimmune epilepsy associated with memory deficits. Research has demonstrated that anti-NMDAR inhibit long-term potentiation, and, at the same time, lead to disinhibition in the form of epileptiform afterp …
Anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis is an autoimmune epilepsy associated with memory deficits. Research has demonst …
The software defined implantable modular platform (STELLA) for preclinical deep brain stimulation research in rodents.
Plocksties F, Kober M, Niemann C, Heller J, Fauser M, Nüssel M, Uster F, Franz D, Zwar M, Lüttig A, Kröger J, Harloff J, Schulz A, Richter A, Köhling R, Timmermann D, Storch A. Plocksties F, et al. Among authors: kohling r. J Neural Eng. 2021 Sep 21;18(5). doi: 10.1088/1741-2552/ac23e1. J Neural Eng. 2021. PMID: 34542029
Context.Long-term deep brain stimulation (DBS) studies in rodents are of crucial importance for research progress in this field. However, most stimulation devices require jackets or large head-mounted systems which severely affect mobility and general welfare influencing a …
Context.Long-term deep brain stimulation (DBS) studies in rodents are of crucial importance for research progress in this field. Howe …
Kv7 and Kir6 Channels Shape the Slow AHP in Mouse Dentate Gyrus Granule Cells and Control Burst-like Firing Behavior.
Laker D, Tolle F, Stegen M, Heerdegen M, Köhling R, Kirschstein T, Wolfart J. Laker D, et al. Among authors: kohling r. Neuroscience. 2021 Jul 15;467:56-72. doi: 10.1016/j.neuroscience.2021.05.025. Epub 2021 May 25. Neuroscience. 2021. PMID: 34048798
Application of 100 M nickel after XE991 and tolbutamide detected a third conductance contributing to burst-like firing and the sAHP, most likely mediated by T-type calcium channels. Lastly, medial perforant path-dentate gyrus long-term potentiation was amplified by XE991 a …
Application of 100 M nickel after XE991 and tolbutamide detected a third conductance contributing to burst-like firing and the sAHP, most li …
Deep brain stimulation by optimized stimulators in a phenotypic model of dystonia: Effects of different frequencies.
Paap M, Perl S, Lüttig A, Plocksties F, Niemann C, Timmermann D, Bahls C, van Rienen U, Franz D, Zwar M, Rohde M, Köhling R, Richter A. Paap M, et al. Among authors: kohling r. Neurobiol Dis. 2021 Jan;147:105163. doi: 10.1016/j.nbd.2020.105163. Epub 2020 Nov 6. Neurobiol Dis. 2021. PMID: 33166698 Free article.
The response to EPN-DBS confirms that the dt(sz) mutant is suitable to further investigate the effects of long-term DBS on severity of dystonia and neuronal network activities, important to give insights into the mechanisms of DBS....
The response to EPN-DBS confirms that the dt(sz) mutant is suitable to further investigate the effects of long-term DBS on severity o …
Stereotactically Injected Kv1.2 and CASPR2 Antisera Cause Differential Effects on CA1 Synaptic and Cellular Excitability, but Both Enhance the Vulnerability to Pro-epileptic Conditions.
Kirschstein T, Sadkiewicz E, Hund-Göschel G, Becker J, Guli X, Müller S, Rohde M, Hübner DC, Brehme H, Kolbaske S, Porath K, Sellmann T, Großmann A, Wittstock M, Syrbe S, Storch A, Köhling R. Kirschstein T, et al. Among authors: kohling r. Front Synaptic Neurosci. 2020 Mar 25;12:13. doi: 10.3389/fnsyn.2020.00013. eCollection 2020. Front Synaptic Neurosci. 2020. PMID: 32269520 Free PMC article.
Using extra- and intracellular techniques, synaptic transmission, long-term potentiation (LTP) and vulnerability to pro-epileptic conditions were analyzed. ...
Using extra- and intracellular techniques, synaptic transmission, long-term potentiation (LTP) and vulnerability to pro-epileptic con …
CK2 Inhibition Prior to Status Epilepticus Persistently Enhances KCa2 Function in CA1 Which Slows Down Disease Progression.
Schulze F, Müller S, Guli X, Schumann L, Brehme H, Riffert T, Rohde M, Goerss D, Rackow S, Einsle A, Kirschstein T, Köhling R. Schulze F, et al. Among authors: kohling r. Front Cell Neurosci. 2020 Feb 26;14:33. doi: 10.3389/fncel.2020.00033. eCollection 2020. Front Cell Neurosci. 2020. PMID: 32174814 Free PMC article.
METHODS: Here, we pretreated rats with TBB in vivo prior to the establishment of a pilocarpine-induced status epilepticus (SE) in order to analyze the long-term sequelae of such a preventive TBB administration. RESULTS: We found that TBB pretreatment delayed onset of seizu …
METHODS: Here, we pretreated rats with TBB in vivo prior to the establishment of a pilocarpine-induced status epilepticus (SE) in order to a …
Novel Object Recognition in Rats With NMDAR Dysfunction in CA1 After Stereotactic Injection of Anti-NMDAR Encephalitis Cerebrospinal Fluid.
Kersten M, Rabbe T, Blome R, Porath K, Sellmann T, Bien CG, Köhling R, Kirschstein T. Kersten M, et al. Among authors: kohling r. Front Neurol. 2019 Jun 5;10:586. doi: 10.3389/fneur.2019.00586. eCollection 2019. Front Neurol. 2019. PMID: 31231304 Free PMC article.
After recovery for 1-8 days, hippocampal slices were prepared from these animals and NMDAR-dependent long-term potentiation was assessed at the Schaffer collateral-CA1 synapse. In addition, we performed behavioral analyses using the open field and novel object recognition …
After recovery for 1-8 days, hippocampal slices were prepared from these animals and NMDAR-dependent long-term potentiation was asses …
Mitochondrial complex IV mutation increases reactive oxygen species production and reduces lifespan in aged mice.
Reichart G, Mayer J, Zehm C, Kirschstein T, Tokay T, Lange F, Baltrusch S, Tiedge M, Fuellen G, Ibrahim S, Köhling R. Reichart G, et al. Among authors: kohling r. Acta Physiol (Oxf). 2019 Apr;225(4):e13214. doi: 10.1111/apha.13214. Epub 2018 Nov 20. Acta Physiol (Oxf). 2019. PMID: 30376218
On the functional level, we could not detect significant differences in synaptic long-term potentiation, but found a markedly poor physical constitution to perform the Morris water maze task at the age of 24 months. ...
On the functional level, we could not detect significant differences in synaptic long-term potentiation, but found a markedly poor ph …
Oral administration of the casein kinase 2 inhibitor TBB leads to persistent KCa2.2 channel up-regulation in the epileptic CA1 area and cortex, but lacks anti-seizure efficacy in the pilocarpine epilepsy model.
Bajorat R, Porath K, Kuhn J, Goßla E, Goerss D, Sellmann T, Köhling R, Kirschstein T. Bajorat R, et al. Among authors: kohling r. Epilepsy Res. 2018 Nov;147:42-50. doi: 10.1016/j.eplepsyres.2018.08.012. Epub 2018 Sep 8. Epilepsy Res. 2018. PMID: 30219695
This prompted us to study the anti-seizure effects of TBB in the pilocarpine model of chronic epilepsy in vivo. To this end, we performed long-term video-EEG monitoring lasting 78-167 days of nine chronically epileptic rats and obtained a baseline seizure rate of 3.3 1.3 p …
This prompted us to study the anti-seizure effects of TBB in the pilocarpine model of chronic epilepsy in vivo. To this end, we performed lo …
30 results