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APRIL: A double-blind, placebo-controlled, randomized, Phase Ib/IIa clinical study of ApTOLL for the treatment of acute ischemic stroke.
Hernández-Jiménez M, Abad-Santos F, Cotgreave I, Gallego J, Jilma B, Flores A, Jovin TG, Vivancos J, Molina CA, Montaner J, Casariego J, Dalsgaard M, Hernández-Pérez M, Liebeskind DS, Cobo E, Ribo M. Hernández-Jiménez M, et al. Among authors: jovin tg. Front Neurol. 2023 Feb 24;14:1127585. doi: 10.3389/fneur.2023.1127585. eCollection 2023. Front Neurol. 2023. PMID: 36908619 Free PMC article.
IDENTIFICATION OF THE TRIAL: EudraCT: 2020-002059-38 and ClinicalTrials.gov Identifier: NCT04734548 https://clinicaltrials.gov/ct2/show/NCT04734548?term=ApTOLL&cond=Stroke&draw=2&rank=1....
IDENTIFICATION OF THE TRIAL: EudraCT: 2020-002059-38 and ClinicalTrials.gov Identifier: NCT04734548 https://clinicaltrials.gov/ct2/show/NCT0 …
Delays in thrombolysis during COVID-19 are associated with worse neurological outcomes: the Society of Vascular and Interventional Neurology Multicenter Collaboration.
Jillella DV, Nahab F, Nguyen TN, Abdalkader M, Liebeskind DS, Vora N, Rai V, Haussen DC, Nogueira RG, Desai S, Jadhav AP, Czap AL, Zha AM, Linfante I, Hassan AE, Quispe-Orozco D, Ortega-Gutierrez S, Khandelwal P, Patel P, Zaidat O, Jovin TG, Kamen S, Siegler JE. Jillella DV, et al. Among authors: jovin tg. J Neurol. 2022 Feb;269(2):603-608. doi: 10.1007/s00415-021-10734-z. Epub 2021 Jul 31. J Neurol. 2022. PMID: 34333701 Free PMC article.
INTRODUCTION: We have demonstrated in a multicenter cohort that the COVID-19 pandemic has led to a delay in intravenous thrombolysis (IVT) among stroke patients. Whether this delay contributes to meaningful short-term outcome differences in these patients warranted further …
INTRODUCTION: We have demonstrated in a multicenter cohort that the COVID-19 pandemic has led to a delay in intravenous thrombolysis (IVT) a …
Endovascular Treatment Effect Diminishes With Increasing Thrombus Perviousness: Pooled Data From 7 Trials on Acute Ischemic Stroke.
Kappelhof M, Tolhuisen ML, Treurniet KM, Dutra BG, Alves H, Zhang G, Brown S, Muir KW, Dávalos A, Roos YBWEM, Saver JL, Demchuk AM, Jovin TG, Bracard S, Campbell BCV, van der Lugt A, Guillemin F, White P, Hill MD, Dippel DWJ, Mitchell PJ, Goyal M, Marquering HA, Majoie CBLM; HERMES Collaborators. Kappelhof M, et al. Among authors: jovin tg. Stroke. 2021 Nov;52(11):3633-3641. doi: 10.1161/STROKEAHA.120.033124. Epub 2021 Jul 20. Stroke. 2021. PMID: 34281377 Free PMC article.
RESULTS: Increased perviousness was associated with improved functional outcome. After adding a multiplicative term of thrombus attenuation increase and treatment allocation, model fit improved significantly (P=0.03), indicating interaction between perviousness and EVT ben …
RESULTS: Increased perviousness was associated with improved functional outcome. After adding a multiplicative term of thrombus atten …
Stroke etiologies in patients with COVID-19: the SVIN COVID-19 multinational registry.
Ramos-Araque ME, Siegler JE, Ribo M, Requena M, López C, de Lera M, Arenillas JF, Pérez IH, Gómez-Vicente B, Talavera B, Portela PC, Guillen AN, Urra X, Llull L, Renú A, Nguyen TN, Jillella D, Nahab F, Nogueira R, Haussen D, Then R, Thon JM, Esparragoza LR, Hernández-Pérez M, Bustamante A, Mansour OY, Megahed M, Hassan T, Liebeskind DS, Hassan A, Bushnaq S, Osman M, Vazquez AR; SVIN Multinational Registry and Task Force. Ramos-Araque ME, et al. BMC Neurol. 2021 Jan 30;21(1):43. doi: 10.1186/s12883-021-02075-1. BMC Neurol. 2021. PMID: 33514335 Free PMC article.
In a large multinational cohort of consecutive COVID-19 patients with stroke, we evaluated clinical predictors of cryptogenic stroke, short-term functional outcomes and in-hospital mortality among patients according to stroke etiology. METHODS: We explored clinical charact …
In a large multinational cohort of consecutive COVID-19 patients with stroke, we evaluated clinical predictors of cryptogenic stroke, short- …
Effect of atrial fibrillation on endovascular thrombectomy for acute ischemic stroke. A meta-analysis of individual patient data from six randomised trials: Results from the HERMES collaboration.
Smaal JA, de Ridder IR, Heshmatollah A, van Zwam WH, Dippel D, Majoie CB, Brown S, Goyal M, Campbell B, Muir KW, Demchuck AM, Davalos A, Jovin TG, Mitchell PJ, White P, Saver JL, Hill MD, Roos YB, van der Lugt A, van Oostenbrugge RJ; HERMES collaboration. Smaal JA, et al. Among authors: jovin tg. Eur Stroke J. 2020 Sep;5(3):245-251. doi: 10.1177/2396987320923447. Epub 2020 May 13. Eur Stroke J. 2020. PMID: 33072878 Free PMC article.
The primary effect parameter was the adjusted common odds ratio, estimated with ordinal logistic regression (shift analysis); treatment effect modification of atrial fibrillation was assessed with a multiplicative interaction term. RESULTS: Among 1351 patients, 447 patient …
The primary effect parameter was the adjusted common odds ratio, estimated with ordinal logistic regression (shift analysis); treatment effe …
Falling stroke rates during COVID-19 pandemic at a comprehensive stroke center.
Siegler JE, Heslin ME, Thau L, Smith A, Jovin TG. Siegler JE, et al. Among authors: jovin tg. J Stroke Cerebrovasc Dis. 2020 Aug;29(8):104953. doi: 10.1016/j.jstrokecerebrovasdis.2020.104953. Epub 2020 May 14. J Stroke Cerebrovasc Dis. 2020. PMID: 32689621 Free PMC article.
PATIENTS AND METHODS: A Comprehensive Stroke Center prospective cohort was retrospectively analyzed for the number of stroke admissions, demographic features, and short-term outcomes 5 months prior to 3/1/2020 (pre-COVID-19), and in the 6 weeks that followed (COVID-19 peri …
PATIENTS AND METHODS: A Comprehensive Stroke Center prospective cohort was retrospectively analyzed for the number of stroke admissions, dem …
Pivotal Trial of the Neuroform Atlas Stent for Treatment of Anterior Circulation Aneurysms: One-Year Outcomes.
Zaidat OO, Hanel RA, Sauvageau EA, Aghaebrahim A, Lin E, Jadhav AP, Jovin TG, Khaldi A, Gupta RG, Johnson A, Frei D, Loy D, Malek A, Toth G, Siddiqui A, Reavey-Cantwell J, Thomas A, Hetts SW, Jankowitz BT; ATLAS Investigators. Zaidat OO, et al. Among authors: jovin tg. Stroke. 2020 Jul;51(7):2087-2094. doi: 10.1161/STROKEAHA.119.028418. Epub 2020 Jun 17. Stroke. 2020. PMID: 32568654 Free PMC article. Clinical Trial.
CONCLUSIONS: In the ATLAS IDE anterior circulation aneurysm cohort premarket approval study, the Neuroform Atlas stent with adjunctive coiling met the primary end points and demonstrated high rates of long-term complete aneurysm occlusion at 12 months, with 100% technical …
CONCLUSIONS: In the ATLAS IDE anterior circulation aneurysm cohort premarket approval study, the Neuroform Atlas stent with adjunctive coili …
Predicting outcomes after acute reperfusion therapy for basilar artery occlusion.
Jadhav AP, Desai SM, Panczykowski DM, Rangaraju S, Campbell D, Ritvonen JK, Schreiner M, Silvennoinen H, Gerber J, Puetz V, Raza SA, Haussen DC, Nogueira RG, Strbian D, Jovin TG, Lindsberg PJ. Jadhav AP, et al. Among authors: jovin tg. Eur J Neurol. 2020 Nov;27(11):2176-2184. doi: 10.1111/ene.14406. Epub 2020 Jul 28. Eur J Neurol. 2020. PMID: 32558040
BACKGROUND AND PURPOSE: Basilar artery occlusion (BAO) leads to high rates of morbidity and mortality, despite successful recanalization. The discordance between flow restoration and long-term functional status clouds clinical decision-making regarding further aggressive c …
BACKGROUND AND PURPOSE: Basilar artery occlusion (BAO) leads to high rates of morbidity and mortality, despite successful recanalization. Th …
Public Health and Cost Benefits of Successful Reperfusion After Thrombectomy for Stroke.
Kunz WG, Almekhlafi MA, Menon BK, Saver JL, Hunink MG, Dippel DWJ, Majoie CBLM, Liebeskind DS, Jovin TG, Davalos A, Bracard S, Guillemin F, Campbell BCV, Mitchell PJ, White P, Muir KW, Brown S, Demchuk AM, Hill MD, Goyal M; HERMES Collaborators. Kunz WG, et al. Among authors: jovin tg. Stroke. 2020 Mar;51(3):899-907. doi: 10.1161/STROKEAHA.119.027874. Epub 2020 Jan 22. Stroke. 2020. PMID: 31964289
Conclusions- Improved reperfusion grants patients with stroke additional QALYs and leads to long-term cost savings. Procedural strategies to achieve complete reperfusion should be assessed for safety and feasibility, even when initial reperfusion seems to be adequate....
Conclusions- Improved reperfusion grants patients with stroke additional QALYs and leads to long-term cost savings. Procedural strate …
A new era for stroke therapy: Integrating neurovascular protection with optimal reperfusion.
Shi L, Rocha M, Leak RK, Zhao J, Bhatia TN, Mu H, Wei Z, Yu F, Weiner SL, Ma F, Jovin TG, Chen J. Shi L, et al. Among authors: jovin tg. J Cereb Blood Flow Metab. 2018 Dec;38(12):2073-2091. doi: 10.1177/0271678X18798162. Epub 2018 Sep 7. J Cereb Blood Flow Metab. 2018. PMID: 30191760 Free PMC article. Review.
Furthermore, only a small fraction of preclinical studies included long-term functional assessments, aged animals of both genders, and models with stroke comorbidities. ...
Furthermore, only a small fraction of preclinical studies included long-term functional assessments, aged animals of both genders, an …
18 results