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Developmental programming in human umbilical cord vein endothelial cells following fetal growth restriction.
Terstappen F, Calis JJA, Paauw ND, Joles JA, van Rijn BB, Mokry M, Plösch T, Lely AT. Terstappen F, et al. Among authors: joles ja. Clin Epigenetics. 2020 Nov 30;12(1):185. doi: 10.1186/s13148-020-00980-9. Clin Epigenetics. 2020. PMID: 33256815 Free PMC article.
Our approach, involving transcriptomic profiling by RNA-sequencing and gene set enrichment analysis focused on cardiovascular and renal gene sets and targeted DNA methylation assays, contributes to the identification of targets underlying long-term cardiovascular and renal …
Our approach, involving transcriptomic profiling by RNA-sequencing and gene set enrichment analysis focused on cardiovascular and renal gene …
Exenatide twice-daily does not affect renal function or albuminuria compared to titrated insulin glargine in patients with type 2 diabetes mellitus: A post-hoc analysis of a 52-week randomised trial.
Muskiet MHA, Bunck MC, Heine RJ, Cornér A, Yki-Järvinen H, Eliasson B, Joles JA, Diamant M, Tonneijck L, van Raalte DH. Muskiet MHA, et al. Among authors: joles ja. Diabetes Res Clin Pract. 2019 Jul;153:14-22. doi: 10.1016/j.diabres.2019.05.001. Epub 2019 May 9. Diabetes Res Clin Pract. 2019. PMID: 31078666 Clinical Trial.
AIMS: To compare the effects of long-term treatment with the GLP-1RA exenatide twice-daily versus titrated insulin glargine (iGlar) on renal function and albuminuria in type 2 diabetes (T2DM) patients. ...
AIMS: To compare the effects of long-term treatment with the GLP-1RA exenatide twice-daily versus titrated insulin glargine (iGlar) o …
Prenatal Sildenafil Therapy Improves Cardiovascular Function in Fetal Growth Restricted Offspring of Dahl Salt-Sensitive Rats.
Terstappen F, Spradley FT, Bakrania BA, Clarke SM, Joles JA, Paauw ND, Garrett MR, Lely AT, Sasser JM. Terstappen F, et al. Among authors: joles ja. Hypertension. 2019 May;73(5):1120-1127. doi: 10.1161/HYPERTENSIONAHA.118.12454. Hypertension. 2019. PMID: 30827146 Free PMC article.
Fetal growth restriction (FGR) is associated with increased risk for cardiovascular and renal disorders in later life. Prenatal sildenafil improves birth weight in FGR animal models. Whether sildenafil treatment protects against long-term cardiovascular and renal di …
Fetal growth restriction (FGR) is associated with increased risk for cardiovascular and renal disorders in later life. Prenatal sildenafil i …
Elevated renal tissue oxygenation in premature fetal growth restricted neonates: An observational study.
Terstappen F, Paauw ND, Alderliesten T, Joles JA, Vijlbrief DC, Lely AT, Lemmers PMA. Terstappen F, et al. Among authors: joles ja. PLoS One. 2018 Sep 20;13(9):e0204268. doi: 10.1371/journal.pone.0204268. eCollection 2018. PLoS One. 2018. PMID: 30235316 Free PMC article.
Renal artery blood flow (pulsatility and resistance index) was measured within 24 hours after birth. A linear mixed model approach was used (intercept slope = r) to analyze the NIRS parameters. ...How these observations correlate with short- and long-term renal func …
Renal artery blood flow (pulsatility and resistance index) was measured within 24 hours after birth. A linear mixed model approach wa …
Extravascular renal denervation ameliorates juvenile hypertension and renal damage resulting from experimental hyperleptinemia in rats.
Oosterhuis NR, Fernandes R, Maicas N, Bae SE, Pombo J, Gremmels H, Poston L, Joles JA, Samuelsson AM. Oosterhuis NR, et al. Among authors: joles ja. J Hypertens. 2017 Dec;35(12):2537-2547. doi: 10.1097/HJH.0000000000001472. J Hypertens. 2017. PMID: 28704264
CONCLUSION: We propose that neonatal hyperleptinemia programmes long-term renal structural and functional damage, through renal sympathetic nerve activation....
CONCLUSION: We propose that neonatal hyperleptinemia programmes long-term renal structural and functional damage, through renal sympa …
Innovative Perspective: Gadolinium-Free Magnetic Resonance Imaging in Long-Term Follow-Up after Kidney Transplantation.
van Eijs MJM, van Zuilen AD, de Boer A, Froeling M, Nguyen TQ, Joles JA, Leiner T, Verhaar MC. van Eijs MJM, et al. Among authors: joles ja. Front Physiol. 2017 May 16;8:296. doi: 10.3389/fphys.2017.00296. eCollection 2017. Front Physiol. 2017. PMID: 28559850 Free PMC article. Review.
We propose that functional MRI mechanistically provides tools for diagnostic work-up in long-term follow-up of kidney allografts....
We propose that functional MRI mechanistically provides tools for diagnostic work-up in long-term follow-up of kidney allografts....
Exposure to placental ischemia impairs postpartum maternal renal and cardiac function in rats.
Paauw ND, Joles JA, Spradley FT, Bakrania B, Zsengeller ZK, Franx A, Verhaar MC, Granger JP, Lely AT. Paauw ND, et al. Among authors: joles ja. Am J Physiol Regul Integr Comp Physiol. 2017 May 1;312(5):R664-R670. doi: 10.1152/ajpregu.00510.2016. Epub 2017 Feb 15. Am J Physiol Regul Integr Comp Physiol. 2017. PMID: 28202440 Free PMC article.
In rats, we assessed whether placental ischemia results in long-term effects on the maternal cardiovascular and renal systems using the reduced uterine perfusion pressure (RUPP) model for PE. ...
In rats, we assessed whether placental ischemia results in long-term effects on the maternal cardiovascular and renal systems using t …
High-Normal Estimated Glomerular Filtration Rate in Early-Onset Preeclamptic Women 10 Years Postpartum.
Paauw ND, Joles JA, Drost JT, Verhaar MC, Franx A, Navis G, Maas AH, Lely AT. Paauw ND, et al. Among authors: joles ja. Hypertension. 2016 Dec;68(6):1407-1414. doi: 10.1161/HYPERTENSIONAHA.116.08227. Epub 2016 Oct 31. Hypertension. 2016. PMID: 27802418
Whether these subtle differences predispose to or predict long-term renal function loss in fPE women remains to be investigated. ...
Whether these subtle differences predispose to or predict long-term renal function loss in fPE women remains to be investigated. ...
Central role for melanocortin-4 receptors in offspring hypertension arising from maternal obesity.
Samuelsson AS, Mullier A, Maicas N, Oosterhuis NR, Eun Bae S, Novoselova TV, Chan LF, Pombo JM, Taylor PD, Joles JA, Coen CW, Balthasar N, Poston L. Samuelsson AS, et al. Among authors: joles ja. Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):12298-12303. doi: 10.1073/pnas.1607464113. Epub 2016 Oct 6. Proc Natl Acad Sci U S A. 2016. PMID: 27791019 Free PMC article.
Early-life exposure of the PVH to maternal obesity through postnatal elevation of leptin may have long-term consequences for cardiovascular health....
Early-life exposure of the PVH to maternal obesity through postnatal elevation of leptin may have long-term consequences for cardiova …
Pregnancy as a critical window for blood pressure regulation in mother and child: programming and reprogramming.
Paauw ND, van Rijn BB, Lely AT, Joles JA. Paauw ND, et al. Among authors: joles ja. Acta Physiol (Oxf). 2017 Jan;219(1):241-259. doi: 10.1111/apha.12702. Epub 2016 May 26. Acta Physiol (Oxf). 2017. PMID: 27124608 Review.
Pregnancy is a critical time for long-term blood pressure regulation in both mother and child. Pregnancies complicated by placental insufficiency, resulting in pre-eclampsia and intrauterine growth restriction, are associated with a threefold increased risk of the mother t …
Pregnancy is a critical time for long-term blood pressure regulation in both mother and child. Pregnancies complicated by placental i …
24 results