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Achromobacter spp. in a Cohort of Non-Selected Pre- and Post-Lung Transplant Recipients.
Crone CG, Rezahosseini O, Schultz HHL, Qvist T, Johansen HK, Nielsen SD, Perch M. Crone CG, et al. Among authors: johansen hk. Pathogens. 2022 Jan 28;11(2):181. doi: 10.3390/pathogens11020181. Pathogens. 2022. PMID: 35215124 Free PMC article.
Achromobacter spp. mainly affected LTXr with CF as the underlying disease and was rare in non-CF LTXr. Larger studies are needed to assess long-term outcomes of Achromobacter spp. in LTXr....
Achromobacter spp. mainly affected LTXr with CF as the underlying disease and was rare in non-CF LTXr. Larger studies are needed to assess l …
A retrospective review of Achromobacter species and antibiotic treatments in patients with primary ciliary dyskinesia.
Holgersen MG, Marthin JK, Johansen HK, Nielsen KG. Holgersen MG, et al. Among authors: johansen hk. Chron Respir Dis. 2021 Jan-Dec;18:14799731211061600. doi: 10.1177/14799731211061600. Chron Respir Dis. 2021. PMID: 34854775 Free PMC article.
Conclusion The prevalence of Achromobacter species in patients with PCD is in line with what has been reported in cystic fibrosis and can occur transiently, intermittently, or develop into a serious persistent lung infection associated with long-term antibiotic treatment.. …
Conclusion The prevalence of Achromobacter species in patients with PCD is in line with what has been reported in cystic fibrosis and can oc …
Adaptive Interactions of Achromobacter spp. with Pseudomonas aeruginosa in Cystic Fibrosis Chronic Lung Co-Infection.
Sandri A, Haagensen JAJ, Veschetti L, Johansen HK, Molin S, Malerba G, Signoretto C, Boaretti M, Lleo MM. Sandri A, et al. Among authors: johansen hk. Pathogens. 2021 Aug 3;10(8):978. doi: 10.3390/pathogens10080978. Pathogens. 2021. PMID: 34451442 Free PMC article.
To evaluate the possible evolution of such interplay, we assessed the ability of Achromobacter spp. isolates to affect the biofilm formation of co-isolated P. aeruginosa strains during long-term chronic co-infections. We observed both competition and cohabitation. ...
To evaluate the possible evolution of such interplay, we assessed the ability of Achromobacter spp. isolates to affect the biofilm formation …
Compensatory evolution of Pseudomonas aeruginosa's slow growth phenotype suggests mechanisms of adaptation in cystic fibrosis.
La Rosa R, Rossi E, Feist AM, Johansen HK, Molin S. La Rosa R, et al. Among authors: johansen hk. Nat Commun. 2021 May 27;12(1):3186. doi: 10.1038/s41467-021-23451-y. Nat Commun. 2021. PMID: 34045458 Free PMC article.
Long-term infection of the airways of cystic fibrosis patients with Pseudomonas aeruginosa is often accompanied by a reduction in bacterial growth rate. ...
Long-term infection of the airways of cystic fibrosis patients with Pseudomonas aeruginosa is often accompanied by a reduction in bac …
Bacterial persisters in long-term infection: Emergence and fitness in a complex host environment.
Bartell JA, Cameron DR, Mojsoska B, Haagensen JAJ, Pressler T, Sommer LM, Lewis K, Molin S, Johansen HK. Bartell JA, et al. Among authors: johansen hk. PLoS Pathog. 2020 Dec 14;16(12):e1009112. doi: 10.1371/journal.ppat.1009112. eCollection 2020 Dec. PLoS Pathog. 2020. PMID: 33315938 Free PMC article.
In sum, the Hip phenotype appears to substantially contribute to long-term establishment of a lineage in the CF lung environment. Our results argue against the existence of a single dominant molecular mechanism underlying bacterial antibiotic persistence. ...
In sum, the Hip phenotype appears to substantially contribute to long-term establishment of a lineage in the CF lung environment. Our …
Gene Loss and Acquisition in Lineages of Pseudomonas aeruginosa Evolving in Cystic Fibrosis Patient Airways.
Gabrielaite M, Johansen HK, Molin S, Nielsen FC, Marvig RL. Gabrielaite M, et al. Among authors: johansen hk. mBio. 2020 Oct 27;11(5):e02359-20. doi: 10.1128/mBio.02359-20. mBio. 2020. PMID: 33109761 Free PMC article.
Here, we investigated P. aeruginosa within-host evolution with regard to gene loss and acquisition. We show that during long-term infection P. aeruginosa genomes tend to lose genes, in particular, genes related to virulence. ...
Here, we investigated P. aeruginosa within-host evolution with regard to gene loss and acquisition. We show that during long-term inf …
Hypermutator Pseudomonas aeruginosa Exploits Multiple Genetic Pathways To Develop Multidrug Resistance during Long-Term Infections in the Airways of Cystic Fibrosis Patients.
Colque CA, Albarracín Orio AG, Feliziani S, Marvig RL, Tobares AR, Johansen HK, Molin S, Smania AM. Colque CA, et al. Among authors: johansen hk. Antimicrob Agents Chemother. 2020 Apr 21;64(5):e02142-19. doi: 10.1128/AAC.02142-19. Print 2020 Apr 21. Antimicrob Agents Chemother. 2020. PMID: 32071060 Free PMC article.
Convergent Metabolic Specialization through Distinct Evolutionary Paths in Pseudomonas aeruginosa.
La Rosa R, Johansen HK, Molin S. La Rosa R, et al. Among authors: johansen hk. mBio. 2018 Apr 10;9(2):e00269-18. doi: 10.1128/mBio.00269-18. mBio. 2018. PMID: 29636437 Free PMC article.
Evolution by natural selection under complex and dynamic environmental conditions occurs through intricate and often counterintuitive trajectories affecting many genes and metabolic solutions. To study short- and long-term evolution of bacteria in vivo, we used the natural …
Evolution by natural selection under complex and dynamic environmental conditions occurs through intricate and often counterintuitive trajec …
Clinical care of children with primary ciliary dyskinesia.
Lucas JS, Alanin MC, Collins S, Harris A, Johansen HK, Nielsen KG, Papon JF, Robinson P, Walker WT. Lucas JS, et al. Among authors: johansen hk. Expert Rev Respir Med. 2017 Oct;11(10):779-790. doi: 10.1080/17476348.2017.1360770. Epub 2017 Aug 2. Expert Rev Respir Med. 2017. PMID: 28745925 Review.
Abnormal ciliary function in childhood leads to neonatal respiratory distress in term infants, persistent wet cough, bronchiectasis, chronic rhinosinusitis, and hearing impairment; approximately 50% of patients have situs inversus. ...
Abnormal ciliary function in childhood leads to neonatal respiratory distress in term infants, persistent wet cough, bronchiectasis, …
33 results