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Sulfur Amino Acid Supplementation Abrogates Protective Effects of Caloric Restriction for Enhancing Bone Marrow Regrowth Following Ionizing Radiation.
Hine C, Treviño-Villarreal JH, Mejia P, Longchamp A, Brace LE, Harputlugil E, Mitchell SJ, Yang J, Guan Y, Maciejewski JP, Jha BK, Mitchell JR. Hine C, et al. Among authors: jha bk. Nutrients. 2022 Apr 6;14(7):1529. doi: 10.3390/nu14071529. Nutrients. 2022. PMID: 35406143 Free PMC article.
The exogenous addition of H(2)S inhibited Ten eleven translocation 2 (TET2) activity in vitro, thus providing a potential mechanism of action. Short-term CR or fasting therefore offers BM radioprotection and promotes regrowth in part via altered sulfur amino acid metabolis …
The exogenous addition of H(2)S inhibited Ten eleven translocation 2 (TET2) activity in vitro, thus providing a potential mechanism of actio …
Interaction of tacrolimus through hedgehog signaling pathway: An in vitro evaluation using rat hepatocytes.
Fatima N, Sheikh N, Satoskar AR, Jha BK, Akhtar T, Tayyeb A, Ashfaq I. Fatima N, et al. Among authors: jha bk. Hum Exp Toxicol. 2021 Nov;40(11):1955-1961. doi: 10.1177/09603271211017313. Epub 2021 May 12. Hum Exp Toxicol. 2021. PMID: 33977768
Tacrolimus (TAC) is the drug of choice in immunosuppressive therapy for organ transplantation; however, adverse effects are still a major concern. The current study aims to decipher the short-term exposure of TAC on rat hepatocytes in relation to activation of hedgehog (HH …
Tacrolimus (TAC) is the drug of choice in immunosuppressive therapy for organ transplantation; however, adverse effects are still a major co …
Effect of Short-Term Tacrolimus Exposure on Rat Liver: An Insight into Serum Antioxidant Status, Liver Lipid Peroxidation, and Inflammation.
Fatima N, Sheikh N, Satoskar AR, Akhtar T, Tayyeb A, Ashfaq I, Ryan N, Ambreen S, Jha BK, Oghumu S. Fatima N, et al. Among authors: jha bk. Mediators Inflamm. 2021 Feb 24;2021:6613786. doi: 10.1155/2021/6613786. eCollection 2021. Mediators Inflamm. 2021. PMID: 33679236 Free PMC article.
In retrospect, a multitude of studies have reported effects of TAC, such as nephrotoxicity, diabetes, and other complications. However, limited information is available regarding short-term exposure of TAC on the liver. Therefore, the present study was designed to unravel …
In retrospect, a multitude of studies have reported effects of TAC, such as nephrotoxicity, diabetes, and other complications. However, limi …