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The structure-function relationship of Pseudomonas aeruginosa in infections and its influence on the microenvironment.
Lichtenberg M, Jakobsen TH, Kühl M, Kolpen M, Jensen PØ, Bjarnsholt T. Lichtenberg M, et al. Among authors: jensen po. FEMS Microbiol Rev. 2022 Sep 2;46(5):fuac018. doi: 10.1093/femsre/fuac018. FEMS Microbiol Rev. 2022. PMID: 35472245 Free PMC article. Review.
While intensively studied, the basic mechanisms enabling the long-term survival of P. aeruginosa in the host, despite massive immune system attack and heavy antimicrobial treatment, remain to be identified. ...
While intensively studied, the basic mechanisms enabling the long-term survival of P. aeruginosa in the host, despite massive immune …
Potential Advances of Adjunctive Hyperbaric Oxygen Therapy in Infective Endocarditis.
Lerche CJ, Schwartz F, Pries-Heje MM, Fosbøl EL, Iversen K, Jensen PØ, Høiby N, Hyldegaard O, Bundgaard H, Moser C. Lerche CJ, et al. Among authors: jensen po. Front Cell Infect Microbiol. 2022 Feb 3;12:805964. doi: 10.3389/fcimb.2022.805964. eCollection 2022. Front Cell Infect Microbiol. 2022. PMID: 35186793 Free PMC article. Review.
New therapeutic options in IE are much needed and adjunctive HBOT might be a therapeutic option in certain IE patients to decrease morbidity and mortality and improve the long-term outcome of this severe disease....
New therapeutic options in IE are much needed and adjunctive HBOT might be a therapeutic option in certain IE patients to decrease morbidity …
Revival of Krebs-Ringer balanced salt solution for the investigation of polymorphonuclear leukocytes and Pseudomonas aeruginosa biofilm interaction.
Bjarnsholt T, Jensen PØ, Alhede M. Bjarnsholt T, et al. Among authors: jensen po. Pathog Dis. 2019 Jul 1;77(5):ftz052. doi: 10.1093/femspd/ftz052. Pathog Dis. 2019. PMID: 31529027
We show that Krebs-Ringer BSS prolonged the survival of PMNs compared to HBSS and RPMI 1640 and that the addition of 10% FBS significantly enhanced the long-term survival (20 h) compared to HS. Furthermore, we observed aggregation of Pseudomonas aeruginosa when grown in th …
We show that Krebs-Ringer BSS prolonged the survival of PMNs compared to HBSS and RPMI 1640 and that the addition of 10% FBS significantly e …
Modelling of ciprofloxacin killing enhanced by hyperbaric oxygen treatment in Pseudomonas aeruginosa PAO1 biofilms.
Gade PAV, Olsen TB, Jensen PØ, Kolpen M, Høiby N, Henneberg KÅ, Sams T. Gade PAV, et al. Among authors: jensen po. PLoS One. 2018 Jun 14;13(6):e0198909. doi: 10.1371/journal.pone.0198909. eCollection 2018. PLoS One. 2018. PMID: 29902223 Free PMC article.
The complete oxygen model comprises a reaction-diffusion equation describing the oxygen consumption by using a Michaelis-Menten reaction term. The oxygen model performed well in predicting oxygen concentrations in both time and depth into the biofilm. At 2.8 bar pure oxyge …
The complete oxygen model comprises a reaction-diffusion equation describing the oxygen consumption by using a Michaelis-Menten reaction …
Microenvironmental characteristics and physiology of biofilms in chronic infections of CF patients are strongly affected by the host immune response.
Jensen PØ, Kolpen M, Kragh KN, Kühl M. Jensen PØ, et al. APMIS. 2017 Apr;125(4):276-288. doi: 10.1111/apm.12668. APMIS. 2017. PMID: 28407427 Review.
High levels of nitrate and nitrite enable P. aeruginosa to persist fueled by denitrification in the PMN-surrounded biofilm aggregates. This configuration creates a potentially long-term stable ecological niche for P. aeruginosa in the CF lung, which is largely governed by …
High levels of nitrate and nitrite enable P. aeruginosa to persist fueled by denitrification in the PMN-surrounded biofilm aggregates. This …
The effect of short-term, high-dose oral N-acetylcysteine treatment on oxidative stress markers in cystic fibrosis patients with chronic P. aeruginosa infection -- a pilot study.
Skov M, Pressler T, Lykkesfeldt J, Poulsen HE, Jensen PØ, Johansen HK, Qvist T, Kræmer D, Høiby N, Ciofu O. Skov M, et al. Among authors: jensen po. J Cyst Fibros. 2015 Mar;14(2):211-8. doi: 10.1016/j.jcf.2014.09.015. Epub 2014 Oct 23. J Cyst Fibros. 2015. PMID: 25458464 Free article. Clinical Trial.
Sublethal ciprofloxacin treatment leads to rapid development of high-level ciprofloxacin resistance during long-term experimental evolution of Pseudomonas aeruginosa.
Jørgensen KM, Wassermann T, Jensen PØ, Hengzuang W, Molin S, Høiby N, Ciofu O. Jørgensen KM, et al. Among authors: jensen po. Antimicrob Agents Chemother. 2013 Sep;57(9):4215-21. doi: 10.1128/AAC.00493-13. Epub 2013 Jun 17. Antimicrob Agents Chemother. 2013. PMID: 23774442 Free PMC article.
The dynamics of occurrence and the genetic basis of ciprofloxacin resistance were studied in a long-term evolution experiment (940 generations) in wild-type, reference strain (PAO1) and hypermutable (PAOdeltamutS and PAOMY-Mgm) P. aeruginosa populations continuously expose …
The dynamics of occurrence and the genetic basis of ciprofloxacin resistance were studied in a long-term evolution experiment (940 ge …
Quorum sensing and virulence of Pseudomonas aeruginosa during lung infection of cystic fibrosis patients.
Bjarnsholt T, Jensen PØ, Jakobsen TH, Phipps R, Nielsen AK, Rybtke MT, Tolker-Nielsen T, Givskov M, Høiby N, Ciofu O; Scandinavian Cystic Fibrosis Study Consortium. Bjarnsholt T, et al. Among authors: jensen po. PLoS One. 2010 Apr 12;5(4):e10115. doi: 10.1371/journal.pone.0010115. PLoS One. 2010. PMID: 20404933 Free PMC article.
To elucidate the dynamics of P. aeruginosa QS systems during long term infection of the CF lung, we have investigated 238 isolates obtained from 152 CF patients at different stages of infection ranging from intermittent to late chronic. ...
To elucidate the dynamics of P. aeruginosa QS systems during long term infection of the CF lung, we have investigated 238 isolates ob …