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Surgomics: personalized prediction of morbidity, mortality and long-term outcome in surgery using machine learning on multimodal data.
Wagner M, Brandenburg JM, Bodenstedt S, Schulze A, Jenke AC, Stern A, Daum MTJ, Mündermann L, Kolbinger FR, Bhasker N, Schneider G, Krause-Jüttler G, Alwanni H, Fritz-Kebede F, Burgert O, Wilhelm D, Fallert J, Nickel F, Maier-Hein L, Dugas M, Distler M, Weitz J, Müller-Stich BP, Speidel S. Wagner M, et al. Among authors: jenke ac. Surg Endosc. 2022 Nov;36(11):8568-8591. doi: 10.1007/s00464-022-09611-1. Epub 2022 Sep 28. Surg Endosc. 2022. PMID: 36171451 Free PMC article.
Based on the expert survey (n = 66 participants) the feature category with the highest clinical relevance as rated by surgeons was "surgical skill and quality of performance" for morbidity and mortality (9.0 1.3 on a numerical rating scale from 1 to 10) as well as for long-ter
Based on the expert survey (n = 66 participants) the feature category with the highest clinical relevance as rated by surgeons was "surgical …
Impact of an In-House Pediatric Surgery Unit and Human Milk Centered Enteral Nutrition on Necrotizing Enterocolitis.
Zamrik S, Giachero F, Heldmann M, Hensel KO, Wirth S, Jenke AC. Zamrik S, et al. Among authors: jenke ac. Biomed Res Int. 2018 Nov 13;2018:5042707. doi: 10.1155/2018/5042707. eCollection 2018. Biomed Res Int. 2018. PMID: 30539013 Free PMC article.
The importance for mortality and morbidity of an in-house pediatric surgery unit for premature infants with necrotizing enterocolitis (NEC) remains undefined. Data on 389 consecutive very low birth weight infants with a birth weight <1250 g admitted between 2009 …
The importance for mortality and morbidity of an in-house pediatric surgery unit for premature infants with necrotizing enterocolitis (NEC) …
Neonatal exposure to hyperoxia leads to persistent disturbances in pulmonary histone signatures associated with NOS3 and STAT3 in a mouse model.
Chao CM, van den Bruck R, Lork S, Merkle J, Krampen L, Weil PP, Aydin M, Bellusci S, Jenke AC, Postberg J. Chao CM, et al. Among authors: jenke ac. Clin Epigenetics. 2018 Mar 20;10:37. doi: 10.1186/s13148-018-0469-0. eCollection 2018. Clin Epigenetics. 2018. PMID: 29581793 Free PMC article.
BACKGROUND: Early pulmonary oxygen exposure is one of the most important factors implicated in the development of bronchopulmonary dysplasia (BPD). METHODS: Here, we analyzed short- and long-term effects of neonatal hyperoxia on NOS3 and STAT3 expression and corresponding …
BACKGROUND: Early pulmonary oxygen exposure is one of the most important factors implicated in the development of bronchopulmonary dysplasia …
The influence of real-time blood glucose levels on left ventricular myocardial strain and strain rate in pediatric patients with type 1 diabetes mellitus - a speckle tracking echocardiography study.
Hensel KO, Grimmer F, Jenke AC, Wirth S, Heusch A. Hensel KO, et al. Among authors: jenke ac. BMC Cardiovasc Disord. 2015 Dec 21;15:175. doi: 10.1186/s12872-015-0171-5. BMC Cardiovasc Disord. 2015. PMID: 26691324 Free PMC article.
BACKGROUND: Echocardiographic myocardial performance parameters such as strain and strain rate are increasingly used to assess systolic and diastolic function in patients with diabetes mellitus and several other clinical and scientific scenarios. While long-term metabolic …
BACKGROUND: Echocardiographic myocardial performance parameters such as strain and strain rate are increasingly used to assess systolic and …
Operative management of cryptorchidism: guidelines and reality--a 10-year observational analysis of 3587 cases.
Hensel KO, Caspers T, Jenke AC, Schuler E, Wirth S. Hensel KO, et al. Among authors: jenke ac. BMC Pediatr. 2015 Sep 10;15:116. doi: 10.1186/s12887-015-0429-1. BMC Pediatr. 2015. PMID: 26357871 Free PMC article.
Timing of orchidopexy must be optimized in order to improve long-term prognosis. Both primary care providers and parents should be educated regarding the advantages of early orchidopexy in UDT. ...
Timing of orchidopexy must be optimized in order to improve long-term prognosis. Both primary care providers and parents should be ed …
Restitution of gene expression and histone acetylation signatures altered by hepatitis B virus through antiviral microRNA-like molecules in nontransformed murine hepatocytes.
Jenke AC, Hensel KO, Klein A, Willuhn L, Prax S, Weil PP, Winkler T, Deba T, Orth V, Baiker A, Wirth S, Postberg J. Jenke AC, et al. Clin Epigenetics. 2014 Nov 14;6(1):26. doi: 10.1186/1868-7083-6-26. eCollection 2014. Clin Epigenetics. 2014. PMID: 25859285 Free PMC article.
Neither such epigenome changes nor their response to antiviral treatment have been extensively studied to date, although viral infections are known to contribute to the long-term development of severe secondary diseases, for example, hepatocellular carcinoma. ...
Neither such epigenome changes nor their response to antiviral treatment have been extensively studied to date, although viral infections ar …
Long-term suppression of hepatitis B virus replication by short hairpin RNA expression using the scaffold/matrix attachment region-based replicating vector system pEPI-1.
Jenke AC, Wilhelm AD, Orth V, Lipps HJ, Protzer U, Wirth S. Jenke AC, et al. Antimicrob Agents Chemother. 2008 Jul;52(7):2355-9. doi: 10.1128/AAC.00067-08. Epub 2008 May 12. Antimicrob Agents Chemother. 2008. PMID: 18474581 Free PMC article.
Since the emergence of viral resistance of hepatitis B virus (HBV) during treatment is becoming an important issue even with newer drugs, there is a need for alternative treatment options such as, for example, RNA interference (RNAi) technology. While short-term suppressio …
Since the emergence of viral resistance of hepatitis B virus (HBV) during treatment is becoming an important issue even with newer drugs, th …
The nonviral episomal replicating vector pEPI-1 allows long-term inhibition of bcr-abl expression by shRNA.
Jenke AC, Eisenberger T, Baiker A, Stehle IM, Wirth S, Lipps HJ. Jenke AC, et al. Hum Gene Ther. 2005 Apr;16(4):533-9. doi: 10.1089/hum.2005.16.533. Hum Gene Ther. 2005. PMID: 15871685
These results demonstrate that the vector system pEPI-1 allows specific and efficient long term gene suppression by using a short hairpin RNA transcription unit....
These results demonstrate that the vector system pEPI-1 allows specific and efficient long term gene suppression by using a short hai …
Expression of a transgene encoded on a non-viral episomal vector is not subject to epigenetic silencing by cytosine methylation.
Jenke AC, Scinteie MF, Stehle IM, Lipps HJ. Jenke AC, et al. Mol Biol Rep. 2004 Jun;31(2):85-90. doi: 10.1023/b:mole.0000031363.35839.46. Mol Biol Rep. 2004. PMID: 15293783
The ideal vector has to be free of these side effects and should allow long-term expression of a transgene in the absence of selection. In this report we describe a novel non-viral episomal expression system fulfilling these criteria. ...Moreover, we provide the first expe …
The ideal vector has to be free of these side effects and should allow long-term expression of a transgene in the absence of selectio …