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Non-random genetic alterations in the cyanobacterium Nostoc sp. exposed to space conditions.
Liu Y, Jeraldo P, Herbert W, McDonough S, Eckloff B, de Vera JP, Cockell C, Leya T, Baqué M, Jen J, Schulze-Makuch D, Walther-Antonio M. Liu Y, et al. Among authors: jen j. Sci Rep. 2022 Jul 22;12(1):12580. doi: 10.1038/s41598-022-16789-w. Sci Rep. 2022. PMID: 35869252 Free PMC article.
Understanding the impact of long-term exposure of microorganisms to space is critical in understanding how these exposures impact the evolution and adaptation of microbial life under space conditions. ...The cause(s) of these non-random alterations and their implications t …
Understanding the impact of long-term exposure of microorganisms to space is critical in understanding how these exposures impact the …
Novel de novo TREX1 mutation in a patient with retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations mimicking demyelinating disease.
Macaron G, Khoury J, Hajj-Ali RA, Prayson RA, Srivastava S, Ehlers JP, Mamsa H, Liszewski MK, Jen JC, Bermel RA, Ontaneda D. Macaron G, et al. Among authors: jen jc. Mult Scler Relat Disord. 2021 Jul;52:103015. doi: 10.1016/j.msard.2021.103015. Epub 2021 May 7. Mult Scler Relat Disord. 2021. PMID: 34044261
Only one de novo case has been reported in the literature. We report the long-term clinical, radiological, and pathological presentation of a patient with a de novo and novel mutation in this gene. ...
Only one de novo case has been reported in the literature. We report the long-term clinical, radiological, and pathological presentat …
High frequency electrical stimulation promotes expression of extracellular matrix proteins from human astrocytes.
Jang JS, Choi CI, Yi J, Butters K, Kim I, Bhagwate A, Jen J, Chang SY. Jang JS, et al. Among authors: jen j. Mol Biol Rep. 2019 Aug;46(4):4369-4375. doi: 10.1007/s11033-019-04890-9. Epub 2019 Jul 2. Mol Biol Rep. 2019. PMID: 31267326 Free PMC article.
Our results suggest that astrocytes are involved in the long-term modulation of extra cellular matrix environments and that they may influence persistent cell-to-cell interaction and help maintain neuromodulation over time....
Our results suggest that astrocytes are involved in the long-term modulation of extra cellular matrix environments and that they may …
A DRD1 polymorphism predisposes to lung cancer among those exposed to secondhand smoke during childhood.
Robles AI, Yang P, Jen J, McClary AC, Calhoun K, Bowman ED, Vähäkangas K, Greathouse KL, Wang Y, Olivo-Marston S, Wenzlaff AS, Deng B, Schwartz AG, Ryan BM. Robles AI, et al. Among authors: jen j. Cancer Prev Res (Phila). 2014 Dec;7(12):1210-8. doi: 10.1158/1940-6207.CAPR-14-0158. Epub 2014 Oct 3. Cancer Prev Res (Phila). 2014. PMID: 25281486 Free PMC article.

This relationship was evident in both ever (OR, 0.74; 95% CI, 0.62-0.88; P = 0.001) and never smokers (OR, 0.61; 95% CI, 0.47-0.79; P < 0.0001), European American (OR, 0.65; 95% CI, 0.53-0.80; P < 0.0001), and African American (OR, 0.73; 95% CI, 0.62-0.88; P = 0.001) popula

…

This relationship was evident in both ever (OR, 0.74; 95% CI, 0.62-0.88; P = 0.001) and never smokers (OR, 0.61; 95% CI, 0.47-0.79; P < 0

…
Quality assessment metrics for whole genome gene expression profiling of paraffin embedded samples.
Mahoney DW, Therneau TM, Anderson SK, Jen J, Kocher JP, Reinholz MM, Perez EA, Eckel-Passow JE. Mahoney DW, et al. Among authors: jen j. BMC Res Notes. 2013 Jan 30;6:33. doi: 10.1186/1756-0500-6-33. BMC Res Notes. 2013. PMID: 23360712 Free PMC article.
BACKGROUND: Formalin fixed, paraffin embedded tissues are most commonly used for routine pathology analysis and for long term tissue preservation in the clinical setting. Many institutions have large archives of Formalin fixed, paraffin embedded tissues that provide a uniq …
BACKGROUND: Formalin fixed, paraffin embedded tissues are most commonly used for routine pathology analysis and for long term tissue …
EGFR somatic mutations in lung tumors: radon exposure and passive smoking in former- and never-smoking U.S. women.
Taga M, Mechanic LE, Hagiwara N, Vähäkangas KH, Bennett WP, Alavanja MC, Welsh JA, Khan MA, Lee A, Diasio R, Edell E, Bungum A, Jang JS, Yang P, Jen J, Harris CC. Taga M, et al. Among authors: jen j. Cancer Epidemiol Biomarkers Prev. 2012 Jun;21(6):988-92. doi: 10.1158/1055-9965.EPI-12-0166. Epub 2012 Apr 20. Cancer Epidemiol Biomarkers Prev. 2012. PMID: 22523180 Free PMC article.
METHODS: This hypothesis was investigated by analyzing EGFR mutations in 70 lung tumors from a population of never and long-term former female smokers from Missouri with detailed exposure assessments. ...
METHODS: This hypothesis was investigated by analyzing EGFR mutations in 70 lung tumors from a population of never and long-term form …
Recurrent deep vein thrombosis: long-term incidence and natural history.
Labropoulos N, Jen J, Jen H, Gasparis AP, Tassiopoulos AK. Labropoulos N, et al. Among authors: jen j. Ann Surg. 2010 Apr;251(4):749-53. doi: 10.1097/SLA.0b013e3181d568db. Ann Surg. 2010. PMID: 20224361 Free article.
OBJECTIVE: To determine the long-term incidence, risk factors, and associated morbidity and mortality of recurrent deep vein thrombosis (DVT). SUMMARY BACKGROUND DATA: Few studies have examined the long-term natural history and impact of recurrent DVT. METHODS: We c …
OBJECTIVE: To determine the long-term incidence, risk factors, and associated morbidity and mortality of recurrent deep vein thrombos …
Individualized Cognition-Action intervention to prevent behavioral disturbances and functional decline in institutionalized older adults: a randomized pilot trial.
Dechamps A, Alban R, Jen J, Decamps A, Traissac T, Dehail P. Dechamps A, et al. Among authors: jen j. Int J Geriatr Psychiatry. 2010 Aug;25(8):850-60. doi: 10.1002/gps.2427. Int J Geriatr Psychiatry. 2010. PMID: 19946868 Clinical Trial.
DESIGN: 12 weeks randomized pilot trial of either individualized Cognition-Action program (n = 24) or routine medical care as control (C, n = 25). SETTING: Long-term care (LTC) of the Geriatric Department from the University State Hospital in Bordeaux, France. ...
DESIGN: 12 weeks randomized pilot trial of either individualized Cognition-Action program (n = 24) or routine medical care as control (C, n …
Promoter hypermethylation patterns of p16, O6-methylguanine-DNA-methyltransferase, and death-associated protein kinase in tumors and saliva of head and neck cancer patients.
Rosas SL, Koch W, da Costa Carvalho MG, Wu L, Califano J, Westra W, Jen J, Sidransky D. Rosas SL, et al. Among authors: jen j. Cancer Res. 2001 Feb 1;61(3):939-42. Cancer Res. 2001. PMID: 11221887
Detection of aberrant promoter hypermethylation patterns of cancer-related genes in saliva of head and cancer patients is feasible and may be potentially useful for detecting and monitoring disease recurrence. Long-term longitudinal studies are needed to evaluate this appr …
Detection of aberrant promoter hypermethylation patterns of cancer-related genes in saliva of head and cancer patients is feasible and may b …
Enhancement of the glutamate response by cAMP-dependent protein kinase in hippocampal neurons.
Greengard P, Jen J, Nairn AC, Stevens CF. Greengard P, et al. Among authors: jen j. Science. 1991 Sep 6;253(5024):1135-8. doi: 10.1126/science.1716001. Science. 1991. PMID: 1716001
Receptor channels activated by glutamate, an excitatory neurotransmitter in the mammalian brain, are involved in processes such as long-term potentiation and excitotoxicity. Studies of glutamate receptor channels expressed in cultured hippocampal pyramidal neurons reveal t …
Receptor channels activated by glutamate, an excitatory neurotransmitter in the mammalian brain, are involved in processes such as long-t …