Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

Search Results

8 results

Filters applied: . Clear all
Page 1
Multiple tissue-specific epigenetic alterations regulate persistent gene expression changes following developmental DES exposure in mouse reproductive tissues.
Jefferson TB, Wang T, Jefferson WN, Li Y, Hamilton KJ, Wade PA, Williams CJ, Korach KS. Jefferson TB, et al. Among authors: jefferson wn. Epigenetics. 2023 Dec;18(1):2139986. doi: 10.1080/15592294.2022.2139986. Epub 2022 Nov 3. Epigenetics. 2023. PMID: 36328762 Free PMC article.
Clinically, developmental exposure to the endocrine disrupting chemical, diethylstilboestrol (DES), results in long-term male and female infertility. Experimentally, developmental exposure to DES results in abnormal reproductive tract phenotypes in male and female mice. .. …
Clinically, developmental exposure to the endocrine disrupting chemical, diethylstilboestrol (DES), results in long-term male and fem …
Epithelial membrane protein 2 (EMP2) deficiency alters placental angiogenesis, mimicking features of human placental insufficiency.
Williams CJ, Chu A, Jefferson WN, Casero D, Sudhakar D, Khurana N, Hogue CP, Aryasomayajula C, Patel P, Sullivan P, Padilla-Banks E, Mohandessi S, Janzen C, Wadehra M. Williams CJ, et al. Among authors: jefferson wn. J Pathol. 2017 Jun;242(2):246-259. doi: 10.1002/path.4893. Epub 2017 May 3. J Pathol. 2017. PMID: 28295343 Free PMC article.
To determine if these results translated to human pregnancy, placentas from normal, term deliveries or those complicated by placental insufficiency resulting in intrauterine growth restriction (IUGR) were stained for EMP2. ...
To determine if these results translated to human pregnancy, placentas from normal, term deliveries or those complicated by placental …
Circulating levels of genistein in the neonate, apart from dose and route, predict future adverse female reproductive outcomes.
Jefferson WN, Williams CJ. Jefferson WN, et al. Reprod Toxicol. 2011 Apr;31(3):272-9. doi: 10.1016/j.reprotox.2010.10.001. Epub 2010 Oct 15. Reprod Toxicol. 2011. PMID: 20955782 Free PMC article. Review.
Here we review studies quantifying the amount of phytoestrogen exposure in human adults and infants and discuss the few available epidemiological studies that have addressed long-term consequences of developmental phytoestrogen exposure. We then describe in detail rodent m …
Here we review studies quantifying the amount of phytoestrogen exposure in human adults and infants and discuss the few available epidemiolo …
Prenatal exposure to bisphenol a at environmentally relevant doses adversely affects the murine female reproductive tract later in life.
Newbold RR, Jefferson WN, Padilla-Banks E. Newbold RR, et al. Among authors: jefferson wn. Environ Health Perspect. 2009 Jun;117(6):879-85. doi: 10.1289/ehp.0800045. Epub 2009 Jan 15. Environ Health Perspect. 2009. PMID: 19590677 Free PMC article.
OBJECTIVES: In this study we investigated whether prenatal BPA causes long-term adverse effects in female reproductive tissues in an experimental animal model previously shown useful in studying effects of prenatal DES. ...We did not observe these lesions in controls. CONC …
OBJECTIVES: In this study we investigated whether prenatal BPA causes long-term adverse effects in female reproductive tissues in an …
Effects of endocrine disruptors on obesity.
Newbold RR, Padilla-Banks E, Jefferson WN, Heindel JJ. Newbold RR, et al. Among authors: jefferson wn. Int J Androl. 2008 Apr;31(2):201-8. doi: 10.1111/j.1365-2605.2007.00858.x. Int J Androl. 2008. PMID: 18315718 Review.
Together, these data suggest new targets (i.e. adipocyte differentiation and mechanisms involved in weight homeostasis) of abnormal programming by EDCs, and provide evidence that support the scientific term 'the developmental origins of adult disease'. The emerging idea of …
Together, these data suggest new targets (i.e. adipocyte differentiation and mechanisms involved in weight homeostasis) of abnormal programm …
Long-term adverse effects of neonatal exposure to bisphenol A on the murine female reproductive tract.
Newbold RR, Jefferson WN, Padilla-Banks E. Newbold RR, et al. Among authors: jefferson wn. Reprod Toxicol. 2007 Aug-Sep;24(2):253-8. doi: 10.1016/j.reprotox.2007.07.006. Epub 2007 Jul 27. Reprod Toxicol. 2007. PMID: 17804194 Free PMC article.
Since concern has been mounting regarding the human health and environmental effects of bisphenol A (BPA), a high-production-volume chemical with estrogenic activity used in the synthesis of plastics, we investigated its long-term effects in an experimental animal model th …
Since concern has been mounting regarding the human health and environmental effects of bisphenol A (BPA), a high-production-volume chemical …
Adverse effects of the model environmental estrogen diethylstilbestrol are transmitted to subsequent generations.
Newbold RR, Padilla-Banks E, Jefferson WN. Newbold RR, et al. Among authors: jefferson wn. Endocrinology. 2006 Jun;147(6 Suppl):S11-7. doi: 10.1210/en.2005-1164. Epub 2006 May 11. Endocrinology. 2006. PMID: 16690809 Review.
In humans and experimental animals, exposure to DES during critical periods of reproductive tract differentiation permanently alters estrogen target tissues and results in long-term abnormalities such as uterine neoplasia that are not manifested until later in life. ...Tog …
In humans and experimental animals, exposure to DES during critical periods of reproductive tract differentiation permanently alters estroge …
Developmental exposure to diethylstilbestrol (DES) alters uterine response to estrogens in prepubescent mice: low versus high dose effects.
Newbold RR, Jefferson WN, Padilla-Banks E, Haseman J. Newbold RR, et al. Among authors: jefferson wn. Reprod Toxicol. 2004 May;18(3):399-406. doi: 10.1016/j.reprotox.2004.01.007. Reprod Toxicol. 2004. PMID: 15082075
A similar dose-response curve was seen in 4 months old ovariectomized DES-treated mice suggesting the altered response was long-term. These data suggest xenoestrogen exposure during critical developmental windows alters hormone programming so that the uterus responds abnor …
A similar dose-response curve was seen in 4 months old ovariectomized DES-treated mice suggesting the altered response was long-term. …