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Safety and efficacy of doravirine as first-line therapy in adults with HIV-1: week 192 results from the open-label extensions of the DRIVE-FORWARD and DRIVE-AHEAD phase 3 trials.
Orkin C, Molina JM, Cahn P, Lombaard J, Supparatpinyo K, Kumar S, Campbell H, Wan H, Teal V, Jin Xu Z, Asante-Appiah E, Sklar P, Teppler H, Lahoulou R; DRIVE-FORWARD and DRIVE-AHEAD collaborators. Orkin C, et al. Lancet HIV. 2024 Feb;11(2):e75-e85. doi: 10.1016/S2352-3018(23)00258-8. Epub 2023 Dec 20. Lancet HIV. 2024. PMID: 38141637 Clinical Trial.
INTERPRETATION: Favourable efficacy and safety profiles for doravirine at week 96 were maintained through to week 192 in participants who continued or switched to doravirine, supporting use of doravirine for long-term first-line HIV-1 treatment and for virologically suppre …
INTERPRETATION: Favourable efficacy and safety profiles for doravirine at week 96 were maintained through to week 192 in participants who co …
Multiple tissue-specific epigenetic alterations regulate persistent gene expression changes following developmental DES exposure in mouse reproductive tissues.
Jefferson TB, Wang T, Jefferson WN, Li Y, Hamilton KJ, Wade PA, Williams CJ, Korach KS. Jefferson TB, et al. Epigenetics. 2023 Dec;18(1):2139986. doi: 10.1080/15592294.2022.2139986. Epub 2022 Nov 3. Epigenetics. 2023. PMID: 36328762 Free PMC article.
Clinically, developmental exposure to the endocrine disrupting chemical, diethylstilboestrol (DES), results in long-term male and female infertility. Experimentally, developmental exposure to DES results in abnormal reproductive tract phenotypes in male and female mice. .. …
Clinically, developmental exposure to the endocrine disrupting chemical, diethylstilboestrol (DES), results in long-term male and fem …
Indo-Pacific humpback dolphin occurrence north of Lantau Island, Hong Kong, based on year-round passive acoustic monitoring.
Munger L, Lammers MO, Cifuentes M, Würsig B, Jefferson TA, Hung SK. Munger L, et al. Among authors: jefferson ta. J Acoust Soc Am. 2016 Oct;140(4):2754. doi: 10.1121/1.4963874. J Acoust Soc Am. 2016. PMID: 27794297
Long-term passive acoustic monitoring (PAM) was conducted to study Indo-Pacific humpback dolphins, Sousa chinensis, as part of environmental impact assessments for several major coastal development projects in Hong Kong waters north of Lantau Island. ...These findings sugg …
Long-term passive acoustic monitoring (PAM) was conducted to study Indo-Pacific humpback dolphins, Sousa chinensis, as part of enviro …
Influenza vaccination for healthcare workers who care for people aged 60 or older living in long-term care institutions.
Thomas RE, Jefferson T, Lasserson TJ. Thomas RE, et al. Among authors: jefferson t. Cochrane Database Syst Rev. 2016 Jun 2;2016(6):CD005187. doi: 10.1002/14651858.CD005187.pub5. Cochrane Database Syst Rev. 2016. PMID: 27251461 Free PMC article. Review.
OBJECTIVES: To identify all randomised controlled trials (RCTs) and non-RCTs assessing the effects of vaccinating healthcare workers on the incidence of laboratory-proven influenza, pneumonia, death from pneumonia and admission to hospital for respiratory illness in those aged 60 …
OBJECTIVES: To identify all randomised controlled trials (RCTs) and non-RCTs assessing the effects of vaccinating healthcare workers on the …
[Facing the unreliability of clinical trials literature].
Jefferson T. Jefferson T. Recenti Prog Med. 2016 Jan;107(1):10-8. doi: 10.1701/2132.23098. Recenti Prog Med. 2016. PMID: 26901365 Italian.
Regulatory documents are probably more reliable than currently accessible other sources but there are many severe limitations to the long-term use of regulatory documents for research synthesis and decision-making. ...
Regulatory documents are probably more reliable than currently accessible other sources but there are many severe limitations to the long- …
Dolutegravir versus placebo in subjects harbouring HIV-1 with integrase inhibitor resistance associated substitutions: 48-week results from VIKING-4, a randomized study.
Akil B, Blick G, Hagins DP, Ramgopal MN, Richmond GJ, Samuel RM, Givens N, Vavro C, Song IH, Wynne B, Ait-Khaled M; VIKING-4 study team. Akil B, et al. Antivir Ther. 2015;20(3):343-8. doi: 10.3851/IMP2878. Epub 2014 Oct 16. Antivir Ther. 2015. PMID: 25321146 Clinical Trial.
VIKING-4 (ING116529) included a placebo-controlled 7-day monotherapy phase to demonstrate that short-term antiviral activity was attributable to DTG. METHODS: VIKING-4 is a Phase III randomized, double-blind study in therapy-experienced adults with integrase inhibitor (INI …
VIKING-4 (ING116529) included a placebo-controlled 7-day monotherapy phase to demonstrate that short-term antiviral activity was attr …
Influenza vaccination for healthcare workers who care for people aged 60 or older living in long-term care institutions.
Thomas RE, Jefferson T, Lasserson TJ. Thomas RE, et al. Among authors: jefferson t. Cochrane Database Syst Rev. 2013 Jul 22;(7):CD005187. doi: 10.1002/14651858.CD005187.pub4. Cochrane Database Syst Rev. 2013. PMID: 23881655 Updated. Review.
OBJECTIVES: To identify all randomised controlled trials (RCTs) and non-RCTs assessing the effects of vaccinating healthcare workers on the incidence of laboratory-proven influenza, pneumonia, death from pneumonia and admission to hospital for respiratory illness in those aged 60 …
OBJECTIVES: To identify all randomised controlled trials (RCTs) and non-RCTs assessing the effects of vaccinating healthcare workers on the …
Type VII collagen associated with the basement membrane of amniotic epithelium forms giant anchoring rivets which penetrate a massive lamina reticularis.
Ockleford CD, McCracken SA, Rimmington LA, Hubbard AR, Bright NA, Cockcroft N, Jefferson TB, Waldron E, d'Lacey C. Ockleford CD, et al. Among authors: jefferson tb. Placenta. 2013 Sep;34(9):727-37. doi: 10.1016/j.placenta.2013.06.002. Epub 2013 Jul 5. Placenta. 2013. PMID: 23834951
Intriguing possible functions of these features include nodes for growth of fibrous collagen sheets and sites of possible enzymatic degradation during regulated amnion weakening approaching term. If these sites are confirmed to be involved in amnion degradation and growth …
Intriguing possible functions of these features include nodes for growth of fibrous collagen sheets and sites of possible enzymatic degradat …
Design innovations and baseline findings in a long-term Parkinson's trial: the National Institute of Neurological Disorders and Stroke Exploratory Trials in Parkinson's Disease Long-Term Study-1.
Elm JJ; NINDS NET-PD Investigators. Elm JJ, et al. Mov Disord. 2012 Oct;27(12):1513-21. doi: 10.1002/mds.25175. Mov Disord. 2012. PMID: 23079770 Free PMC article. Clinical Trial.
A randomized, multicenter, double-blind, parallel-group, placebo-controlled phase III study of creatine (10 g daily) in participants with early, treated PD, the Long-term Study-1 (LS-1), is being conducted by the National Institute of Neurological Disorders and Stroke Expl …
A randomized, multicenter, double-blind, parallel-group, placebo-controlled phase III study of creatine (10 g daily) in participants with ea …
32 results