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Different Frequency of Cyclic Tensile Strain Relates to Anabolic/Catabolic Conditions Consistent with Immunohistochemical Staining Intensity in Tenocytes.
Kubo Y, Hoffmann B, Goltz K, Schnakenberg U, Jahr H, Merkel R, Schulze-Tanzil G, Pufe T, Tohidnezhad M. Kubo Y, et al. Among authors: jahr h. Int J Mol Sci. 2020 Feb 6;21(3):1082. doi: 10.3390/ijms21031082. Int J Mol Sci. 2020. PMID: 32041254 Free PMC article.
Our IHC findings consistent with cell physiology suggest that appropriate stretching can reproduce in vitro short-term tenogenic anabolic/catabolic conditions and allow us to identify an anabolic stretching profile....
Our IHC findings consistent with cell physiology suggest that appropriate stretching can reproduce in vitro short-term tenogenic anab …
Additively manufactured functionally graded biodegradable porous iron.
Li Y, Jahr H, Pavanram P, Bobbert FSL, Paggi U, Zhang XY, Pouran B, Leeflang MA, Weinans H, Zhou J, Zadpoor AA. Li Y, et al. Among authors: jahr h. Acta Biomater. 2019 Sep 15;96:646-661. doi: 10.1016/j.actbio.2019.07.013. Epub 2019 Jul 11. Acta Biomater. 2019. PMID: 31302295
However, no functionally graded porous structures have ever been 3D-printed from biodegradable metals, even though biodegradability is crucial both for full tissue regeneration and for the prevention of implant-associated infections in the long term. Here, we present the f …
However, no functionally graded porous structures have ever been 3D-printed from biodegradable metals, even though biodegradability is cruci …
Osteostatin-coated porous titanium can improve early bone regeneration of cortical bone defects in rats.
van der Stok J, Lozano D, Chai YC, Amin Yavari S, Bastidas Coral AP, Verhaar JA, Gómez-Barrena E, Schrooten J, Jahr H, Zadpoor AA, Esbrit P, Weinans H. van der Stok J, et al. Among authors: jahr h. Tissue Eng Part A. 2015 May;21(9-10):1495-506. doi: 10.1089/ten.TEA.2014.0476. Epub 2015 Mar 10. Tissue Eng Part A. 2015. PMID: 25627039
This effect was initiated after a short burst release and might be related to the observed in vitro upregulation of OPG gene expression by osteostatin in osteoprogenitor cells. Long-term beneficial effects of osteostatin-coated, porous titanium implants on bone regeneratio …
This effect was initiated after a short burst release and might be related to the observed in vitro upregulation of OPG gene expression by o …
Calcineurin/nuclear factor of activated T cells (NFAT) signaling in cobalt-chromium-molybdenum (CoCrMo) particles-induced tumor necrosis factor-α (TNFα) secretion in MLO-Y4 osteocytes.
Orhue V, Kanaji A, Caicedo MS, Virdi AS, Sumner DR, Hallab NJ, Jahr H, Sena K. Orhue V, et al. Among authors: jahr h. J Orthop Res. 2011 Dec;29(12):1867-73. doi: 10.1002/jor.21458. Epub 2011 May 6. J Orthop Res. 2011. PMID: 21557302 Free article.
Aseptic loosening is the devastating long term complication of total hip arthroplasty and orthopedic implant debris has been shown to trigger an intense inflammatory reaction leading to resorption of the bone matrix. ...
Aseptic loosening is the devastating long term complication of total hip arthroplasty and orthopedic implant debris has been shown to …
Clinically translatable cell tracking and quantification by MRI in cartilage repair using superparamagnetic iron oxides.
van Buul GM, Kotek G, Wielopolski PA, Farrell E, Bos PK, Weinans H, Grohnert AU, Jahr H, Verhaar JA, Krestin GP, van Osch GJ, Bernsen MR. van Buul GM, et al. Among authors: jahr h. PLoS One. 2011 Feb 23;6(2):e17001. doi: 10.1371/journal.pone.0017001. PLoS One. 2011. PMID: 21373640 Free PMC article.
We studied superparamagnetic iron oxides (SPIO) for labeling human bone marrow-derived mesenchymal stem cells (hBMSCs) regarding effectivity, cell viability, long term metabolic cell activity, chondrogenic differentiation and hBMSC secretion profile. ...
We studied superparamagnetic iron oxides (SPIO) for labeling human bone marrow-derived mesenchymal stem cells (hBMSCs) regarding effectivity …
Stretch-induced inhibition of Wnt/beta-catenin signaling in mineralizing osteoblasts.
Jansen JH, Eijken M, Jahr H, Chiba H, Verhaar JA, van Leeuwen JP, Weinans H. Jansen JH, et al. Among authors: jahr h. J Orthop Res. 2010 Mar;28(3):390-6. doi: 10.1002/jor.20991. J Orthop Res. 2010. PMID: 19780202 Free article.
We conducted in vitro stretch experiments using human pre-osteoblasts to study short- and long-term effects of mechanical loading on Wnt/beta-catenin signaling. ...
We conducted in vitro stretch experiments using human pre-osteoblasts to study short- and long-term effects of mechanical loading on …
Angiogenic capacity of human adipose-derived stromal cells during adipogenic differentiation: an in vitro study.
Verseijden F, Jahr H, Posthumus-van Sluijs SJ, Ten Hagen TL, Hovius SE, Seynhaeve AL, van Neck JW, van Osch GJ, Hofer SO. Verseijden F, et al. Among authors: jahr h. Tissue Eng Part A. 2009 Feb;15(2):445-52. doi: 10.1089/ten.tea.2007.0429. Tissue Eng Part A. 2009. PMID: 18652540
RESULTS: Gene expression of vascular endothelial growth factor (VEGF), placental growth factor, angiopoietin-1 (ANGPT1), angiopoietin-2 (ANGPT2), and protein secretion of VEGF significantly increased during short-term adipogenic differentiation of hASCs. Moreover, conditio …
RESULTS: Gene expression of vascular endothelial growth factor (VEGF), placental growth factor, angiopoietin-1 (ANGPT1), angiopoietin-2 (ANG …
Effects of iron oxide incorporation for long term cell tracking on MSC differentiation in vitro and in vivo.
Farrell E, Wielopolski P, Pavljasevic P, van Tiel S, Jahr H, Verhaar J, Weinans H, Krestin G, O'Brien FJ, van Osch G, Bernsen M. Farrell E, et al. Among authors: jahr h. Biochem Biophys Res Commun. 2008 May 16;369(4):1076-81. doi: 10.1016/j.bbrc.2008.02.159. Epub 2008 Mar 10. Biochem Biophys Res Commun. 2008. PMID: 18336785
With cell labeling, it is important to demonstrate efficient long term labeling without deleterious effects on cell phenotype and differentiation capacity. We demonstrate long term (7 weeks) retention of superparamagnetic iron oxide particles (SPIO) by mesenchymal s …
With cell labeling, it is important to demonstrate efficient long term labeling without deleterious effects on cell phenotype and dif …
Islet cell transplantation today.
Bretzel RG, Jahr H, Eckhard M, Martin I, Winter D, Brendel MD. Bretzel RG, et al. Among authors: jahr h. Langenbecks Arch Surg. 2007 May;392(3):239-53. doi: 10.1007/s00423-007-0183-4. Epub 2007 Mar 28. Langenbecks Arch Surg. 2007. PMID: 17393180
INTRODUCTION: Long-term studies strongly suggest that tight control of blood glucose can prevent the development and retard the progression of chronic complications of type 1 diabetes mellitus. ...
INTRODUCTION: Long-term studies strongly suggest that tight control of blood glucose can prevent the development and retard the progr …
The role of current product release criteria for identification of human islet preparations suitable for clinical transplantation.
Eckhard M, Brandhorst D, Winter D, Jaeger C, Jahr H, Bretzel RG, Brendel MD. Eckhard M, et al. Among authors: jahr h. Transplant Proc. 2004 Jun;36(5):1528-31. doi: 10.1016/j.transproceed.2004.06.001. Transplant Proc. 2004. PMID: 15251377
BACKGROUND: Alloimmunity, autoimmunity, and nonspecific inflammation are known to be potential determinants for long-term islet survival and insulin independence. Sufficient islet mass is a key determinant. ...However, currently used parameters are not predictive of long- …
BACKGROUND: Alloimmunity, autoimmunity, and nonspecific inflammation are known to be potential determinants for long-term islet survi …
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