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Lower Limits for Reporting High-Sensitivity Cardiac Troponin Assays and Impact of Analytical Performance on Patient Misclassification.
Aakre KM, Apple FS, Mills NL, Meex SJR, Collinson PO; International Federation of Clinical Chemistry Committee on Clinical Applications of Cardiac Biomarkers (IFCC C-CB). Aakre KM, et al. Clin Chem. 2024 Mar 2;70(3):497-505. doi: 10.1093/clinchem/hvad185. Clin Chem. 2024. PMID: 38102065 Review.
BACKGROUND: Cardiac troponin measurements are indispensable for the diagnosis of myocardial infarction and provide useful information for long-term risk prediction of cardiovascular disease. Accelerated diagnostic pathways prevent unnecessary hospital admission, but requir …
BACKGROUND: Cardiac troponin measurements are indispensable for the diagnosis of myocardial infarction and provide useful information for lo …
Incidence and outcomes of high bleeding risk patients with type 1 and type 2 myocardial infarction in a community-based cohort: Application of the Academic Research Consortium High Bleeding Risk Criteria.
Breen TJ, Raphael CE, Ingraham B, Lane C, Huxley S, Roger VL, Jaffe A, Lewis B, Sandoval YB, Prasad A, Rihal CS, Gulati R, Singh M. Breen TJ, et al. Among authors: jaffe a. Int J Cardiol. 2024 Feb 1;396:131565. doi: 10.1016/j.ijcard.2023.131565. Epub 2023 Oct 30. Int J Cardiol. 2024. PMID: 37913957
CONCLUSION: HBR is common among unselected patients with T1MI and T2MI and is associated with increased overall and cardiovascular mortality, recurrent cardiovascular events, and major bleeding on long-term follow up....
CONCLUSION: HBR is common among unselected patients with T1MI and T2MI and is associated with increased overall and cardiovascular mortality …
Single Troponin Measurement to Rule Out Myocardial Infarction: JACC Review Topic of the Week.
Jaffe AS, Body R, Mills NL, Aakre KM, Collinson PO, Saenger A, Hammarsten O, Wereski R, Omland T, Sandoval Y, Ordonez-Llanos J, Apple FS; IFCC Committee on Cardiac Bio-Markers. Jaffe AS, et al. J Am Coll Cardiol. 2023 Jul 4;82(1):60-69. doi: 10.1016/j.jacc.2023.04.040. J Am Coll Cardiol. 2023. PMID: 37380305 Review.
The term "single-sample rule-out" refers to the ability of very low concentrations of high-sensitivity cardiac troponin (hs-cTn) on presentation to exclude acute myocardial infarction with high clinical sensitivity and negative predictive value. ...
The term "single-sample rule-out" refers to the ability of very low concentrations of high-sensitivity cardiac troponin (hs-cTn) on p …
Use of the HEAR Score for 30-Day Risk-Stratification in Emergency Department Patients.
Ola O, Akula A, De Michieli L, Knott JD, Lobo R, Mehta RA, Hodge DO, Gulati R, Sandoval Y, Jaffe AS. Ola O, et al. Among authors: jaffe as. Am J Med. 2023 Sep;136(9):918-926.e5. doi: 10.1016/j.amjmed.2023.04.041. Epub 2023 May 24. Am J Med. 2023. PMID: 37236417
BACKGROUND: The 2021 American College of Cardiology/American Heart Association chest pain guidelines recommend risk scores such as HEAR (History, Electrocardiogram, Age, Risk factors) for short-term risk stratification, yet limited data exist integrating them with high-sen …
BACKGROUND: The 2021 American College of Cardiology/American Heart Association chest pain guidelines recommend risk scores such as HEAR (His …
BEAT CF pulmonary exacerbations core protocol for evaluating the management of pulmonary exacerbations in people with cystic fibrosis.
Schultz A, McLeod C, Berry S, Marsh J, McKenzie A, Messer M, Wood J, Saville B, Jaffe A, Ranganathan S, Stick S, Wark P, Webb S, Snelling T. Schultz A, et al. Among authors: jaffe a. Trials. 2023 Mar 22;24(1):211. doi: 10.1186/s13063-023-07076-8. Trials. 2023. PMID: 36949472 Free PMC article. Clinical Trial.
The BEAT CF PEx cohort will be used to evaluate the comparative effectiveness of interventions for the treatment of PEx requiring intensive therapy (PERITs), with a primary focus on short-term improvements in lung function. This will be achieved through the conduct of coho …
The BEAT CF PEx cohort will be used to evaluate the comparative effectiveness of interventions for the treatment of PEx requiring intensive …
Does Effectiveness of a Brief Substance Use Treatment Depend on PTSD? An Evaluation of Motivational Enhancement Therapy for Active-Duty Army Personnel.
Kaysen D, Jaffe AE, Shoenberger B, Walton TO, Pierce AR, Walker DD. Kaysen D, et al. Among authors: jaffe ae. J Stud Alcohol Drugs. 2022 Nov;83(6):924-933. doi: 10.15288/jsad.22-00011. J Stud Alcohol Drugs. 2022. PMID: 36484590 Free PMC article. Clinical Trial.
Findings suggest that PTSD remission may serve as an early prognostic indicator of long-term alcohol use changes, or alternatively, delivery of MET during heightened transitory distress may be most effective for reducing alcohol use....
Findings suggest that PTSD remission may serve as an early prognostic indicator of long-term alcohol use changes, or alternatively, d …
Mindful Awareness Promotes Resilience: Buffered Links Among Childhood Sexual Abuse Severity, Goal-Directed Emotion Dysregulation, and Psychopathology.
Kumar SA, Brockdorf AN, Jaffe AE, Church HR, Messman TL, DiLillo D. Kumar SA, et al. Among authors: jaffe ae. Mindfulness (N Y). 2022 Apr;13(4):993-1006. doi: 10.1007/s12671-022-01854-2. Epub 2022 Mar 9. Mindfulness (N Y). 2022. PMID: 36185759 Free PMC article.
OBJECTIVES: Childhood sexual abuse is linked to long-term consequences, including depression and anxiety in adulthood. ...
OBJECTIVES: Childhood sexual abuse is linked to long-term consequences, including depression and anxiety in adulthood. ...
Molecular phenotypes associated with antipsychotic drugs in the human caudate nucleus.
Perzel Mandell KA, Eagles NJ, Deep-Soboslay A, Tao R, Han S, Wilton R, Szalay AS, Hyde TM, Kleinman JE, Jaffe AE, Weinberger DR. Perzel Mandell KA, et al. Among authors: jaffe ae. Mol Psychiatry. 2022 Apr;27(4):2061-2067. doi: 10.1038/s41380-022-01453-6. Epub 2022 Mar 2. Mol Psychiatry. 2022. PMID: 35236959 Free PMC article.
As a first look at the molecular effects of antipsychotics in the human brain, the lack of epigenetic effects is unexpected, possibly because long term treatment effects may be relatively stable for extended periods....
As a first look at the molecular effects of antipsychotics in the human brain, the lack of epigenetic effects is unexpected, possibly becaus …
114 results