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Ultra-short-term heart rate variability during resistance exercise in the elderly.
Arêas GPT, Caruso FCR, Simões RP, Castello-Simões V, Jaenisch RB, Sato TO, Cabiddu R, Mendes R, Arena R, Borghi-Silva A. Arêas GPT, et al. Among authors: jaenisch rb. Braz J Med Biol Res. 2018;51(6):e6962. doi: 10.1590/1414-431x20186962. Epub 2018 May 21. Braz J Med Biol Res. 2018. PMID: 29791599 Free PMC article.
The aim of the present study was to compare ultra-short-term HRV analysis with standard short-term HRV analysis during low-intensity, dynamic, lower limb resistance exercise in healthy elderly subjects. ...No significant difference was found at any exercise intensit …
The aim of the present study was to compare ultra-short-term HRV analysis with standard short-term HRV analysis during low-int …
Efficient derivation of microglia-like cells from human pluripotent stem cells.
Muffat J, Li Y, Yuan B, Mitalipova M, Omer A, Corcoran S, Bakiasi G, Tsai LH, Aubourg P, Ransohoff RM, Jaenisch R. Muffat J, et al. Among authors: jaenisch r. Nat Med. 2016 Nov;22(11):1358-1367. doi: 10.1038/nm.4189. Epub 2016 Sep 26. Nat Med. 2016. PMID: 27668937 Free PMC article.
This modular differentiation system allows for the study of microglia in highly defined conditions as they mature in response to developmentally relevant cues, and it provides a framework in which to study the long-term interactions of microglia residing in a tissue-like e …
This modular differentiation system allows for the study of microglia in highly defined conditions as they mature in response to development …
Genetic and molecular identification of three human TPP1 functions in telomerase action: recruitment, activation, and homeostasis set point regulation.
Sexton AN, Regalado SG, Lai CS, Cost GJ, O'Neil CM, Urnov FD, Gregory PD, Jaenisch R, Collins K, Hockemeyer D. Sexton AN, et al. Among authors: jaenisch r. Genes Dev. 2014 Sep 1;28(17):1885-99. doi: 10.1101/gad.246819.114. Epub 2014 Aug 15. Genes Dev. 2014. PMID: 25128433 Free PMC article.
Telomere length homeostasis is essential for the long-term survival of stem cells, and its set point determines the proliferative capacity of differentiated cell lineages by restricting the reservoir of telomeric repeats. ...Using genome engineering of human embryonic stem …
Telomere length homeostasis is essential for the long-term survival of stem cells, and its set point determines the proliferative cap …
Tet1 is critical for neuronal activity-regulated gene expression and memory extinction.
Rudenko A, Dawlaty MM, Seo J, Cheng AW, Meng J, Le T, Faull KF, Jaenisch R, Tsai LH. Rudenko A, et al. Among authors: jaenisch r. Neuron. 2013 Sep 18;79(6):1109-1122. doi: 10.1016/j.neuron.2013.08.003. Neuron. 2013. PMID: 24050401 Free PMC article.
Furthermore, Tet1KO animals exhibited abnormal hippocampal long-term depression and impaired memory extinction. Analysis of the key regulatory gene, Npas4, indicated that its promoter region, containing multiple CpG dinucleotides, is hypermethylated in both naive Tet1KO mi …
Furthermore, Tet1KO animals exhibited abnormal hippocampal long-term depression and impaired memory extinction. Analysis of the key r …
Toward eliminating HLA class I expression to generate universal cells from allogeneic donors.
Torikai H, Reik A, Soldner F, Warren EH, Yuen C, Zhou Y, Crossland DL, Huls H, Littman N, Zhang Z, Tykodi SS, Kebriaei P, Lee DA, Miller JC, Rebar EJ, Holmes MC, Jaenisch R, Champlin RE, Gregory PD, Cooper LJ. Torikai H, et al. Among authors: jaenisch r. Blood. 2013 Aug 22;122(8):1341-9. doi: 10.1182/blood-2013-03-478255. Epub 2013 Jun 5. Blood. 2013. PMID: 23741009 Free PMC article.
Long-term engraftment of allogeneic cells necessitates eluding immune-mediated rejection, which is currently achieved by matching for human leukocyte antigen (HLA) expression, immunosuppression, and/or delivery of donor-derived cells to sanctuary sites. ...
Long-term engraftment of allogeneic cells necessitates eluding immune-mediated rejection, which is currently achieved by matching for …
Matrix remodeling maintains embryonic stem cell self-renewal by activating Stat3.
Przybyla LM, Theunissen TW, Jaenisch R, Voldman J. Przybyla LM, et al. Among authors: jaenisch r. Stem Cells. 2013 Jun;31(6):1097-106. doi: 10.1002/stem.1360. Stem Cells. 2013. PMID: 23404867 Free PMC article.
We also find that addition of the interstitial collagenase MMP1 is sufficient to maintain long-term leukemia inhibitory factor (LIF)-independent mouse ESC (mESC) self-renewal in a dose-dependent manner. ...
We also find that addition of the interstitial collagenase MMP1 is sufficient to maintain long-term leukemia inhibitory factor (LIF)- …
Transnuclear mice with pre-defined T cell receptor specificities against Toxoplasma gondii obtained via SCNT.
Kirak O, Frickel EM, Grotenbreg GM, Suh H, Jaenisch R, Ploegh HL. Kirak O, et al. Among authors: jaenisch r. J Vis Exp. 2010 Sep 30;(43):2168. doi: 10.3791/2168. J Vis Exp. 2010. PMID: 20972401 Free PMC article.
However, such TCRs are usually isolated from the relevant T cells after long-term culture often following repeated antigen stimulation, which unavoidably selects for T cells with high affinity. ...
However, such TCRs are usually isolated from the relevant T cells after long-term culture often following repeated antigen stimulatio …
Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats.
Hargus G, Cooper O, Deleidi M, Levy A, Lee K, Marlow E, Yow A, Soldner F, Hockemeyer D, Hallett PJ, Osborn T, Jaenisch R, Isacson O. Hargus G, et al. Among authors: jaenisch r. Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15921-6. doi: 10.1073/pnas.1010209107. Epub 2010 Aug 23. Proc Natl Acad Sci U S A. 2010. PMID: 20798034 Free PMC article.
Such findings establish the transplantation of human PDiPS cell-derived neurons as a long-term in vivo method to analyze potential disease-related changes in a physiological context. ...
Such findings establish the transplantation of human PDiPS cell-derived neurons as a long-term in vivo method to analyze potential di …
Transnuclear mice with predefined T cell receptor specificities against Toxoplasma gondii obtained via SCNT.
Kirak O, Frickel EM, Grotenbreg GM, Suh H, Jaenisch R, Ploegh HL. Kirak O, et al. Among authors: jaenisch r. Science. 2010 Apr 9;328(5975):243-8. doi: 10.1126/science.1178590. Science. 2010. PMID: 20378817 Free PMC article.
Such TCRs are usually isolated from the relevant T cells after long-term culture, often after repeated antigen stimulation, which unavoidably skews the T cell population used. ...
Such TCRs are usually isolated from the relevant T cells after long-term culture, often after repeated antigen stimulation, which una …
Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotency.
Hanna J, Markoulaki S, Schorderet P, Carey BW, Beard C, Wernig M, Creyghton MP, Steine EJ, Cassady JP, Foreman R, Lengner CJ, Dausman JA, Jaenisch R. Hanna J, et al. Among authors: jaenisch r. Cell. 2008 Apr 18;133(2):250-64. doi: 10.1016/j.cell.2008.03.028. Cell. 2008. PMID: 18423197 Free PMC article.
Multiple iPS lines were clonally derived from both nonfully and fully differentiated B lymphocytes, which gave rise to adult chimeras with germline contribution, and to late-term embryos when injected into tetraploid blastocysts. Our study provides definite proof for the d …
Multiple iPS lines were clonally derived from both nonfully and fully differentiated B lymphocytes, which gave rise to adult chimeras with g …
26 results