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Safety and feasibility of virus-specific T cells derived from umbilical cord blood in cord blood transplant recipients.
Abraham AA, John TD, Keller MD, Cruz CRN, Salem B, Roesch L, Liu H, Hoq F, Grilley BJ, Gee AP, Dave H, Jacobsohn DA, Krance RA, Shpall EJ, Martinez CA, Hanley PJ, Bollard CM. Abraham AA, et al. Among authors: jacobsohn da. Blood Adv. 2019 Jul 23;3(14):2057-2068. doi: 10.1182/bloodadvances.2019000201. Blood Adv. 2019. PMID: 31292125 Free PMC article.
In 7 patients receiving CB-VSTs for viral reactivation or infection, only 1 patient developed end-organ viral disease, which was in an immune privileged site (CMV retinitis) and occurred after steroid therapy for GVHD. Finally, we demonstrated the long-term persistence of …
In 7 patients receiving CB-VSTs for viral reactivation or infection, only 1 patient developed end-organ viral disease, which was in an immun …
Effect of Aging and Predonation Comorbidities on the Related Peripheral Blood Stem Cell Donor Experience: Report from the Related Donor Safety Study.
Pulsipher MA, Logan BR, Chitphakdithai P, Kiefer DM, Riches ML, Rizzo JD, Anderlini P, Leitman SF, Varni JW, Kobusingye H, Besser RM, Miller JP, Drexler RJ, Abdel-Mageed A, Ahmed IA, Akard LP, Artz AS, Ball ED, Bayer RL, Bigelow C, Bolwell BJ, Broun ER, Bunin NJ, Delgado DC, Duckworth K, Dvorak CC, Hahn TE, Haight AE, Hari PN, Hayes-Lattin BM, Jacobsohn DA, Jakubowski AA, Kasow KA, Lazarus HM, Liesveld JL, Linenberger M, Litzow MR, Longo W, Magalhaes-Silverman M, McCarty JM, McGuirk JP, Mori S, Prasad VK, Rowley SD, Rybka WB, Sahdev I, Schriber JR, Selby GB, Shaughnessy PJ, Shenoy S, Spitzer T, Tse WT, Uberti JP, Vusirikala M, Waller EK, Weisdorf DJ, Yanik GA, Navarro WH, Horowitz MM, Switzer GE, Shaw BE, Confer DL. Pulsipher MA, et al. Among authors: jacobsohn da. Biol Blood Marrow Transplant. 2019 Apr;25(4):699-711. doi: 10.1016/j.bbmt.2018.11.004. Epub 2018 Nov 10. Biol Blood Marrow Transplant. 2019. PMID: 30423480 Free PMC article.
The development of reduced-intensity approaches for allogeneic hematopoietic cell transplantation has resulted in growing numbers of older related donors (RDs) of peripheral blood stem cells (PBSCs). The effects of age on donation efficacy, toxicity, and long-term recovery …
The development of reduced-intensity approaches for allogeneic hematopoietic cell transplantation has resulted in growing numbers of older r …
Long-term survival and late effects among one-year survivors of second allogeneic hematopoietic cell transplantation for relapsed acute leukemia and myelodysplastic syndromes.
Duncan CN, Majhail NS, Brazauskas R, Wang Z, Cahn JY, Frangoul HA, Hayashi RJ, Hsu JW, Kamble RT, Kasow KA, Khera N, Lazarus HM, Loren AW, Marks DI, Maziarz RT, Mehta P, Myers KC, Norkin M, Pidala JA, Porter DL, Reddy V, Saber W, Savani BN, Schouten HC, Steinberg A, Wall DA, Warwick AB, Wood WA, Yu LC, Jacobsohn DA, Sorror ML. Duncan CN, et al. Among authors: jacobsohn da. Biol Blood Marrow Transplant. 2015 Jan;21(1):151-8. doi: 10.1016/j.bbmt.2014.10.006. Epub 2014 Oct 12. Biol Blood Marrow Transplant. 2015. PMID: 25316109 Free PMC article.
Among patients with acute leukemia and myelodysplastic syndromes who receive a second allogeneic HCT for relapse and survive disease free for at least 1 year, many can be expected to survive long term. However, they continue to be at risk for relapse and nonrelapse morbidi …
Among patients with acute leukemia and myelodysplastic syndromes who receive a second allogeneic HCT for relapse and survive disease free fo …
Clinical guide to fertility preservation in hematopoietic cell transplant recipients.
Joshi S, Savani BN, Chow EJ, Gilleece MH, Halter J, Jacobsohn DA, Pidala J, Quinn GP, Cahn JY, Jakubowski AA, Kamani NR, Lazarus HM, Rizzo JD, Schouten HC, Socie G, Stratton P, Sorror ML, Warwick AB, Wingard JR, Loren AW, Majhail NS. Joshi S, et al. Among authors: jacobsohn da. Bone Marrow Transplant. 2014 Apr;49(4):477-84. doi: 10.1038/bmt.2013.211. Epub 2014 Jan 13. Bone Marrow Transplant. 2014. PMID: 24419521 Free PMC article. Review.
With broadening indications, more options for hematopoietic cell transplantation (HCT) and improvement in survival, the number of long-term HCT survivors is expected to increase steadily. Infertility is a frequent problem that long-term HCT survivors and their partn …
With broadening indications, more options for hematopoietic cell transplantation (HCT) and improvement in survival, the number of long-te …
Long-term survival in a pediatric patient with supratentorial primitive neuro-ectodermal tumor and extraneural metastasis at diagnosis.
Rubens J, Gosiengfiao Y, Tomita T, Jacobsohn DA, Fangusaro J. Rubens J, et al. Among authors: jacobsohn da. Pediatr Blood Cancer. 2011 Aug;57(2):341-4. doi: 10.1002/pbc.22995. Epub 2011 Feb 4. Pediatr Blood Cancer. 2011. PMID: 21671369
We present a rare occurrence of a 23-month-old patient with long-term survival after diagnosis of stPNET with metastases to the lungs. This patient was treated with surgical resection, induction chemotherapy, tandem autologous hematopoietic cell rescues, and focal radiothe …
We present a rare occurrence of a 23-month-old patient with long-term survival after diagnosis of stPNET with metastases to the lungs …
Fluticasone, azithromycin and montelukast therapy in reducing corticosteroid exposure in bronchiolitis obliterans syndrome after allogeneic hematopoietic SCT: a case series of eight patients.
Norman BC, Jacobsohn DA, Williams KM, Au BK, Au MA, Lee SJ, Moravec CK, Chien JW. Norman BC, et al. Among authors: jacobsohn da. Bone Marrow Transplant. 2011 Oct;46(10):1369-73. doi: 10.1038/bmt.2010.311. Epub 2010 Dec 6. Bone Marrow Transplant. 2011. PMID: 21132024 Free PMC article.
Bronchiolitis obliterans syndrome (BOS) is a devastating pulmonary complication affecting long-term survivors of allogeneic hematopoietic cell transplantation. ...Prednisone exposure in FAM patients was one quarter that of a retrospective-matched group of patients, with mi …
Bronchiolitis obliterans syndrome (BOS) is a devastating pulmonary complication affecting long-term survivors of allogeneic hematopoi …
High WT1 gene expression before haematopoietic stem cell transplant in children with acute myeloid leukaemia predicts poor event-free survival.
Jacobsohn DA, Tse WT, Chaleff S, Rademaker A, Duerst R, Olszewski M, Huang W, Chou PM, Kletzel M. Jacobsohn DA, et al. Br J Haematol. 2009 Sep;146(6):669-74. doi: 10.1111/j.1365-2141.2009.07770.x. Epub 2009 Jul 23. Br J Haematol. 2009. PMID: 19650884 Free article.
Our finding suggests that elevated WT1 gene expression before HSCT in paediatric AML predicts relapse and poor long-term EFS. A larger prospective study is warranted to compare the value of high WT1 expression and other markers of minimal residue disease in predicting clin …
Our finding suggests that elevated WT1 gene expression before HSCT in paediatric AML predicts relapse and poor long-term EFS. A large …
Favorable outcome for infant acute lymphoblastic leukemia after hematopoietic stem cell transplantation.
Jacobsohn DA, Hewlett B, Morgan E, Tse W, Duerst RE, Kletzel M. Jacobsohn DA, et al. Biol Blood Marrow Transplant. 2005 Dec;11(12):999-1005. doi: 10.1016/j.bbmt.2005.08.031. Biol Blood Marrow Transplant. 2005. PMID: 16338622 Free article.
Eight patients received HSCT from an HLA-identical sibling, and 8, from unrelated cord blood. Twelve (75%) patients remain long-term survivors (median follow-up, 4.7 years). Two patients, 1 of whom had minimal residual disease at HSCT, died after relapse following HSCT. .. …
Eight patients received HSCT from an HLA-identical sibling, and 8, from unrelated cord blood. Twelve (75%) patients remain long-term …
Reduced intensity haemopoietic stem-cell transplantation for treatment of non-malignant diseases in children.
Jacobsohn DA, Duerst R, Tse W, Kletzel M. Jacobsohn DA, et al. Lancet. 2004 Jul 10-16;364(9429):156-62. doi: 10.1016/S0140-6736(04)16628-2. Lancet. 2004. PMID: 15246728
Major endpoints were engraftment, transplant-related mortality at day 100, short-term toxicities, and incidence of acute GVHD. RESULTS: 72% of evaluable patients achieved full donor engraftment. There was rapid reconstitution of platelets (median 13.5 days) and neutrophils …
Major endpoints were engraftment, transplant-related mortality at day 100, short-term toxicities, and incidence of acute GVHD. RESULT …