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Early Metabolic Endpoints Identify Persistent Treatment Efficacy in Recent-Onset Type 1 Diabetes Immunotherapy Trials.
Jacobsen LM, Cuthbertson D, Bundy BN, Atkinson MA, Moore W, Haller MJ, Russell WE, Gitelman SE, Herold KC, Redondo MJ, Sims EK, Wherrett DK, Moran A, Pugliese A, Gottlieb PA, Sosenko JM, Ismail HM; Type 1 Diabetes TrialNet Study Group. Jacobsen LM, et al. Diabetes Care. 2024 Apr 15:dc240171. doi: 10.2337/dc24-0171. Online ahead of print. Diabetes Care. 2024. PMID: 38621411

The use of C-peptide AUC as a 6-month dynamic measure not only detected treatment efficacy but also suggested long-term C-peptide preservation (R2 for 12-month C-peptide AUC adjusted for age and baseline value was 0.80, P < 0.001), and this finding supported the concept

…
The use of C-peptide AUC as a 6-month dynamic measure not only detected treatment efficacy but also suggested long-term C-peptide pre …
Low-Protein Infant Formula Enriched with Alpha-Lactalbumin during Early Infancy May Reduce Insulin Resistance at 12 Months: A Follow-Up of a Randomized Controlled Trial.
Tinghäll Nilsson U, Lönnerdal B, Hernell O, Kvistgaard AS, Jacobsen LN, Karlsland Åkeson P. Tinghäll Nilsson U, et al. Among authors: jacobsen ln. Nutrients. 2024 Apr 1;16(7):1026. doi: 10.3390/nu16071026. Nutrients. 2024. PMID: 38613059 Free PMC article. Clinical Trial.
The aim of this follow-up study at 12 months was to evaluate if modified low-protein formulas fed during early infancy have long-term effects on growth and metabolism. In a double-blinded RCT, the ALFoNS study, 245 healthy-term infants received low-protein formulas …
The aim of this follow-up study at 12 months was to evaluate if modified low-protein formulas fed during early infancy have long-term …
Precision stratification of prognostic risk factors associated with outcomes in gestational diabetes mellitus: a systematic review.
Semnani-Azad Z, Gaillard R, Hughes AE, Boyle KE, Tobias DK; ADA/EASD PMDI; Perng W. Semnani-Azad Z, et al. Commun Med (Lond). 2024 Jan 12;4(1):9. doi: 10.1038/s43856-023-00427-1. Commun Med (Lond). 2024. PMID: 38216688 Free PMC article.
We sought to identify factors associated with short- and long-term cardiometabolic disease risk, health conditions that involve heart-related issues and complications in bodily function, among women with GDM and their offspring. ...We found that GDM severity, maternal obes …
We sought to identify factors associated with short- and long-term cardiometabolic disease risk, health conditions that involve heart …
No consistent evidence for the anti-inflammatory effect of vagus nerve stimulation in humans: A systematic review and meta-analysis.
Schiweck C, Sausmekat S, Zhao T, Jacobsen L, Reif A, Edwin Thanarajah S. Schiweck C, et al. Among authors: jacobsen l. Brain Behav Immun. 2024 Feb;116:237-258. doi: 10.1016/j.bbi.2023.12.008. Epub 2023 Dec 7. Brain Behav Immun. 2024. PMID: 38070618
Studies were included if they provided peer-reviewed data for humans who received VNS as short-term (<=1 day) or long-term (>=2 days-365 days) stimulation and reported at least one cytokine or immune cell after treatment.Screening of title, abstract, full text …
Studies were included if they provided peer-reviewed data for humans who received VNS as short-term (<=1 day) or long-term …
Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine.
Tobias DK, Merino J, Ahmad A, Aiken C, Benham JL, Bodhini D, Clark AL, Colclough K, Corcoy R, Cromer SJ, Duan D, Felton JL, Francis EC, Gillard P, Gingras V, Gaillard R, Haider E, Hughes A, Ikle JM, Jacobsen LM, Kahkoska AR, Kettunen JLT, Kreienkamp RJ, Lim LL, Männistö JME, Massey R, Mclennan NM, Miller RG, Morieri ML, Most J, Naylor RN, Ozkan B, Patel KA, Pilla SJ, Prystupa K, Raghavan S, Rooney MR, Schön M, Semnani-Azad Z, Sevilla-Gonzalez M, Svalastoga P, Takele WW, Tam CH, Thuesen ACB, Tosur M, Wallace AS, Wang CC, Wong JJ, Yamamoto JM, Young K, Amouyal C, Andersen MK, Bonham MP, Chen M, Cheng F, Chikowore T, Chivers SC, Clemmensen C, Dabelea D, Dawed AY, Deutsch AJ, Dickens LT, DiMeglio LA, Dudenhöffer-Pfeifer M, Evans-Molina C, Fernández-Balsells MM, Fitipaldi H, Fitzpatrick SL, Gitelman SE, Goodarzi MO, Grieger JA, Guasch-Ferré M, Habibi N, Hansen T, Huang C, Harris-Kawano A, Ismail HM, Hoag B, Johnson RK, Jones AG, Koivula RW, Leong A, Leung GKW, Libman IM, Liu K, Long SA, Lowe WL Jr, Morton RW, Motala AA, Onengut-Gumuscu S, Pankow JS, Pathirana M, Pazmino S, Perez D, Petrie JR, Powe CE, Quinteros A, Jain R, Ray D, Ried-Larsen M, Saeed Z, Santhakumar V, Kanbour S, … See abstract for full author list ➔ Tobias DK, et al. Among authors: jacobsen lm. Nat Med. 2023 Oct;29(10):2438-2457. doi: 10.1038/s41591-023-02502-5. Epub 2023 Oct 5. Nat Med. 2023. PMID: 37794253 Free PMC article. Review.
Although not complete, owing to the vast literature on this topic, they revealed opportunities for the immediate or near-term clinical implementation of precision diabetes medicine; furthermore, we expose important gaps in knowledge, focusing on the need to obtain new clin …
Although not complete, owing to the vast literature on this topic, they revealed opportunities for the immediate or near-term clinica …
Precision gestational diabetes treatment: a systematic review and meta-analyses.
Benham JL, Gingras V, McLennan NM, Most J, Yamamoto JM, Aiken CE, Ozanne SE, Reynolds RM; ADA/EASD PMDI. Benham JL, et al. Commun Med (Lond). 2023 Oct 5;3(1):135. doi: 10.1038/s43856-023-00371-0. Commun Med (Lond). 2023. PMID: 37794196 Free PMC article.
BACKGROUND: Gestational Diabetes Mellitus (GDM) affects approximately 1 in 7 pregnancies globally. It is associated with short- and long-term risks for both mother and baby. Therefore, optimizing treatment to effectively treat the condition has wide-ranging beneficial effe …
BACKGROUND: Gestational Diabetes Mellitus (GDM) affects approximately 1 in 7 pregnancies globally. It is associated with short- and long- …
The use of precision diagnostics for monogenic diabetes: a systematic review and expert opinion.
Murphy R, Colclough K, Pollin TI, Ikle JM, Svalastoga P, Maloney KA, Saint-Martin C, Molnes J; ADA/EASD PMDI; Misra S, Aukrust I, de Franco E, Flanagan SE, Njølstad PR, Billings LK, Owen KR, Gloyn AL. Murphy R, et al. Commun Med (Lond). 2023 Oct 5;3(1):136. doi: 10.1038/s43856-023-00369-8. Commun Med (Lond). 2023. PMID: 37794142 Free PMC article.
Reporting by gene names is recommended as an alternative to the term MODY. Key steps after making a genetic diagnosis and major gaps in our current knowledge are highlighted. ...
Reporting by gene names is recommended as an alternative to the term MODY. Key steps after making a genetic diagnosis and major gaps …
Low-Protein Formulas with Alpha-Lactalbumin-Enriched or Glycomacropeptide-Reduced Whey: Effects on Growth, Nutrient Intake and Protein Metabolism during Early Infancy: A Randomized, Double-Blinded Controlled Trial.
Tinghäll Nilsson U, Hernell O, Lönnerdal B, Hartvigsen ML, Jacobsen LN, Kvistgaard AS, Karlsland Åkeson P. Tinghäll Nilsson U, et al. Among authors: jacobsen ln. Nutrients. 2023 Feb 17;15(4):1010. doi: 10.3390/nu15041010. Nutrients. 2023. PMID: 36839368 Free PMC article. Clinical Trial.
Growth, nutrient intake, and protein metabolites were evaluated in a randomized, prospective, double-blinded intervention trial where term infants received standard formula (SF:2.2 g protein/100 kcal; n = 83) or low-protein formulas with alpha-lac-enriched whey (alpha-lac- …
Growth, nutrient intake, and protein metabolites were evaluated in a randomized, prospective, double-blinded intervention trial where ter …
Factors Associated With Achieving Target A1C in Children and Adolescents With Type 1 Diabetes: Findings From the T1D Exchange Quality Improvement Collaborative.
Demeterco-Berggren C, Ebekozien O, Noor N, Rompicherla S, Majidi S, Jones NY, McDonough R, Odugbesan O, Kim A, Izquierdo R, Kamboj MK, Jacobsen LM. Demeterco-Berggren C, et al. Among authors: jacobsen lm. Clin Diabetes. 2022 Winter;41(1):68-75. doi: 10.2337/cd22-0073. Epub 2022 Aug 30. Clin Diabetes. 2022. PMID: 36714245 Free PMC article.
The optimal care of type 1 diabetes involves consistent glycemic management to avoid short- and long-term complications. However, despite advancements in diabetes technology and standards, achieving adequate glycemic levels in children and adolescents remains a challenge. …
The optimal care of type 1 diabetes involves consistent glycemic management to avoid short- and long-term complications. However, des …
Low-Dose ATG/GCSF in Established Type 1 Diabetes: A Five-Year Follow-up Report.
Lin A, Mack JA, Bruggeman B, Jacobsen LM, Posgai AL, Wasserfall CH, Brusko TM, Atkinson MA, Gitelman SE, Gottlieb PA, Gurka MJ, Mathews CE, Schatz DA, Haller MJ. Lin A, et al. Among authors: jacobsen lm. Diabetes. 2021 May;70(5):1123-1129. doi: 10.2337/db20-1103. Epub 2021 Feb 25. Diabetes. 2021. PMID: 33632742 Free PMC article.
Previously, we demonstrated low-dose antithymocyte globulin (ATG) and granulocyte colony-stimulating factor (GCSF) immunotherapy preserved C-peptide for 2 years in a pilot study of patients with established type 1 diabetes (n = 25). Here, we evaluated the long-term outcome …
Previously, we demonstrated low-dose antithymocyte globulin (ATG) and granulocyte colony-stimulating factor (GCSF) immunotherapy preserved C …
35 results