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Assessment of Toxic Effects and Survival in Treatment Deescalation With Radiotherapy vs Transoral Surgery for HPV-Associated Oropharyngeal Squamous Cell Carcinoma: The ORATOR2 Phase 2 Randomized Clinical Trial.
Palma DA, Prisman E, Berthelet E, Tran E, Hamilton S, Wu J, Eskander A, Higgins K, Karam I, Poon I, Husain Z, Enepekides D, Hier M, Sultanem K, Richardson K, Mlynarek A, Johnson-Obaseki S, Odell M, Bayley A, Dowthwaite S, Jackson JE, Dzienis M, O'Neil J, Chandarana S, Banerjee R, Hart R, Chung J, Tenenholtz T, Krishnan S, Le H, Yoo J, Mendez A, Winquist E, Kuruvilla S, Stewart P, Warner A, Mitchell S, Chen J, Parker C, Wehrli B, Kwan K, Theurer J, Sathya J, Hammond JA, Read N, Venkatesan V, MacNeil SD, Fung K, Nichols AC. Palma DA, et al. Among authors: jackson je. JAMA Oncol. 2022 Jun 1;8(6):1-7. doi: 10.1001/jamaoncol.2022.0615. JAMA Oncol. 2022. PMID: 35482348 Free PMC article. Clinical Trial.
CONCLUSIONS AND RELEVANCE: In this randomized clinical trial, TOS was associated with an unacceptable risk of grade 5 toxic effects, but patients in both trial arms achieved good swallowing outcomes at 1 year. Long-term follow-up is required to assess OS and PFS outcomes. …
CONCLUSIONS AND RELEVANCE: In this randomized clinical trial, TOS was associated with an unacceptable risk of grade 5 toxic effects, but pat …
Long-term safety evaluation of placental mesenchymal stromal cells for in utero repair of myelomeningocele in a novel ovine model.
Stokes SC, Theodorou CM, Jackson JE, Pivetti C, Kumar P, Yamashiro KJ, Paxton ZJ, Reynaga L, Hyllen A, Wang A, Farmer DL. Stokes SC, et al. Among authors: jackson je. J Pediatr Surg. 2022 Jan;57(1):18-25. doi: 10.1016/j.jpedsurg.2021.09.021. Epub 2021 Sep 20. J Pediatr Surg. 2022. PMID: 34657738 Free PMC article.
Lambs underwent magnetic resonance imaging (MRI) of the brain and spine at birth and at three months. All organs from lambs and uteri from ewes underwent histologic evaluation. ...
Lambs underwent magnetic resonance imaging (MRI) of the brain and spine at birth and at three months. All organs from lambs and uteri …
Preliminary Evaluation of a Novel Fetal Guinea Pig Myelomeningocele Model.
Stokes SC, Yamashiro KJ, Vanover MA, Galganski LA, Jackson JE, Theodorou CM, Pivetti CD, Farmer DL, Wang A. Stokes SC, et al. Among authors: jackson je. Biomed Res Int. 2021 Aug 13;2021:2180883. doi: 10.1155/2021/2180883. eCollection 2021. Biomed Res Int. 2021. PMID: 34423032 Free PMC article.
INTRODUCTION: Translational models of myelomeningocele (MMC) are needed to test novel in utero interventions. An ideal animal model for MMC has locomotor function at birth and is low cost enough to allow for high throughput. The rat MMC model is limited by immature locomot …
INTRODUCTION: Translational models of myelomeningocele (MMC) are needed to test novel in utero interventions. An ideal animal model for MMC …
Placental Mesenchymal Stromal Cells: Preclinical Safety Evaluation for Fetal Myelomeningocele Repair.
Jackson JE, Pivetti C, Stokes SC, Theodorou CM, Kumar P, Paxton ZJ, Hyllen A, Reynaga L, Wang A, Farmer DL. Jackson JE, et al. J Surg Res. 2021 Nov;267:660-668. doi: 10.1016/j.jss.2021.06.011. Epub 2021 Jul 15. J Surg Res. 2021. PMID: 34273796 Free PMC article.
We developed clinical-grade placental mesenchymal stromal cells seeded on a dural extracellular matrix (PMSC-ECM), which have been shown to improve motor outcomes in preclinical ovine models. To evaluate the long-term safety of this product prior to use in a clinical trial …
We developed clinical-grade placental mesenchymal stromal cells seeded on a dural extracellular matrix (PMSC-ECM), which have been shown to …
Patient selection for pediatric gastrostomy tubes: Are we placing tubes that are not being used?
Jackson JE, Theodorou CM, Vukcevich O, Brown EG, Beres AL. Jackson JE, et al. J Pediatr Surg. 2022 Mar;57(3):532-537. doi: 10.1016/j.jpedsurg.2021.06.001. Epub 2021 Jun 11. J Pediatr Surg. 2022. PMID: 34229875 Free article.
RESULTS: Fifteen percent (22/142) of GTs were used for <6 months post-operatively. The median duration of short-term GT use was 1.6 months (IQR 0.9-3.4 months). Short-term GTs were more likely to be placed in patients with traumatic brain injury (TBI) (18.2% vs. …
RESULTS: Fifteen percent (22/142) of GTs were used for <6 months post-operatively. The median duration of short-term GT use was 1. …
A Novel Model of Fetal Spinal Cord Exposure Allowing for Long-Term Postnatal Survival.
Stokes SC, Jackson JE, Theodorou CM, Pivetti CD, Kumar P, Yamashiro KJ, Wang A, Farmer DL. Stokes SC, et al. Among authors: jackson je. Fetal Diagn Ther. 2021;48(6):472-478. doi: 10.1159/000516542. Epub 2021 Jun 10. Fetal Diagn Ther. 2021. PMID: 34111873 Free PMC article.
BACKGROUND: The inherent morbidity associated with fetal ovine models of myelomeningocele (MMC) has created challenges for long-term survival of lambs. We aimed to develop a fetal ovine surgical spinal exposure model which could be used to evaluate long-term safety …
BACKGROUND: The inherent morbidity associated with fetal ovine models of myelomeningocele (MMC) has created challenges for long-term …
Long-term impact of abusive head trauma in young children: Outcomes at 5 and 11 years old.
Jackson JE, Beres AL, Theodorou CM, Ugiliweneza B, Boakye M, Nuño M. Jackson JE, et al. J Pediatr Surg. 2021 Dec;56(12):2318-2325. doi: 10.1016/j.jpedsurg.2021.02.019. Epub 2021 Feb 19. J Pediatr Surg. 2021. PMID: 33714452 Free PMC article.
Children <1 year old at the time of AHT were more likely to develop disabilities when compared to 2 year olds. CONCLUSIONS: AHT is associated with significant long-term disability by age 5 and the incidence increased by age 11 years. There is an association between age …
Children <1 year old at the time of AHT were more likely to develop disabilities when compared to 2 year olds. CONCLUSIONS: AHT is associ …
21 results