The Predictive Approaches to Treatment effect Heterogeneity (PATH) Statement.
Kent DM, Paulus JK, van Klaveren D, D'Agostino R, Goodman S, Hayward R, Ioannidis JPA, Patrick-Lake B, Morton S, Pencina M, Raman G, Ross JS, Selker HP, Varadhan R, Vickers A, Wong JB, Steyerberg EW.
Kent DM, et al. Among authors: ioannidis jpa.
Ann Intern Med. 2020 Jan 7;172(1):35-45. doi: 10.7326/M18-3667. Epub 2019 Nov 12.
Ann Intern Med. 2020.
PMID: 31711134
Free PMC article.
The authors distinguish 2 categories of predictive HTE approaches: a "risk-modeling" approach, wherein a multivariable model predicts the risk for an outcome and is applied to disaggregate patients within RCTs to define risk-based variation in benefit, and an "effect-modeling" ap …
The authors distinguish 2 categories of predictive HTE approaches: a "risk-modeling" approach, wherein a multivariable model predicts the ri …