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A Cell-based beta-Lactamase Reporter Gene Assay for the CREB Signaling Pathway.
Xia M, Guo V, Huang R, Inglese J, Nirenberg M, Austin CP. Xia M, et al. Among authors: inglese j. Curr Chem Genomics. 2009 Jan 1;3(1):7-12. doi: 10.2174/1875397300903010007. Curr Chem Genomics. 2009. PMID: 19936037 Free PMC article.
CREB-mediated transcription has been implicated in a wide variety of important physiological processes, including long-term memory, and enhancement of CREB signaling has been suggested as an attractive therapeutic strategy for human memory disorders. ...
CREB-mediated transcription has been implicated in a wide variety of important physiological processes, including long-term memory, a …
Identification of compounds that potentiate CREB signaling as possible enhancers of long-term memory.
Xia M, Huang R, Guo V, Southall N, Cho MH, Inglese J, Austin CP, Nirenberg M. Xia M, et al. Among authors: inglese j. Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2412-7. doi: 10.1073/pnas.0813020106. Epub 2009 Feb 5. Proc Natl Acad Sci U S A. 2009. PMID: 19196967 Free PMC article.
Many studies have implicated the cAMP Response Element Binding (CREB) protein signaling pathway in long-term memory. To identify small molecule enhancers of CREB activation of gene expression, we screened approximately 73,000 compounds, each at 7-15 concentrations in a qua …
Many studies have implicated the cAMP Response Element Binding (CREB) protein signaling pathway in long-term memory. To identify smal …
gamma-Fluoromethotrexate: synthesis and biological activity of a potent inhibitor of dihydrofolate reductase with greatly diminished ability to form poly-gamma-glutamates.
Galivan J, Inglese J, McGuire JJ, Nimec Z, Coward JK. Galivan J, et al. Among authors: inglese j. Proc Natl Acad Sci U S A. 1985 May;82(9):2598-602. doi: 10.1073/pnas.82.9.2598. Proc Natl Acad Sci U S A. 1985. PMID: 2581252 Free PMC article.
The data strongly suggest that prolonged toxicity of MTX is a result of metabolic conversion to MTX polyglutamates and that these effects are far more dramatic in short-term than in long-term exposure to the antifolates....
The data strongly suggest that prolonged toxicity of MTX is a result of metabolic conversion to MTX polyglutamates and that these effects ar …