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Long-term social isolation stress exacerbates sex-specific neurodegeneration markers in a natural model of Alzheimer's disease.
Oliva CA, Lira M, Jara C, Catenaccio A, Mariqueo TA, Lindsay CB, Bozinovic F, Cavieres G, Inestrosa NC, Tapia-Rojas C, Rivera DS. Oliva CA, et al. Among authors: inestrosa nc. Front Aging Neurosci. 2023 Sep 20;15:1250342. doi: 10.3389/fnagi.2023.1250342. eCollection 2023. Front Aging Neurosci. 2023. PMID: 37810621 Free PMC article.
Indeed, social isolation stress (SIS) is indicative of cognitive decline and risk to neurodegenerative conditions, including Alzheimer's disease (AD). This study aimed to evaluate the impact of chronic, long-term SIS on the propensity to develop hallmarks of AD in young de …
Indeed, social isolation stress (SIS) is indicative of cognitive decline and risk to neurodegenerative conditions, including Alzheimer's dis …
Cardiovascular and autonomic dysfunction in long-COVID syndrome and the potential role of non-invasive therapeutic strategies on cardiovascular outcomes.
Allendes FJ, Díaz HS, Ortiz FC, Marcus NJ, Quintanilla R, Inestrosa NC, Del Rio R. Allendes FJ, et al. Among authors: inestrosa nc. Front Med (Lausanne). 2023 Jan 19;9:1095249. doi: 10.3389/fmed.2022.1095249. eCollection 2022. Front Med (Lausanne). 2023. PMID: 36743679 Free PMC article.
This post-COVID-19 cardiovascular syndrome is one facet of "long-COVID," generally defined as long-term health problems persisting/appearing after the typical recovery period of COVID-19. ...
This post-COVID-19 cardiovascular syndrome is one facet of "long-COVID," generally defined as long-term health problems persisting/ap …
Age-Dependent Behavioral and Synaptic Dysfunction Impairment Are Improved with Long-Term Andrographolide Administration in Long-Lived Female Degus (Octodon degus).
Oliva CA, Rivera DS, Torres AK, Lindsay CB, Tapia-Rojas C, Bozinovic F, Inestrosa NC. Oliva CA, et al. Among authors: inestrosa nc. Int J Mol Sci. 2023 Jan 6;24(2):1105. doi: 10.3390/ijms24021105. Int J Mol Sci. 2023. PMID: 36674622 Free PMC article.
Sociability was also not affected by age; however, social recognition and long-term memory were lower in the aged females than adults but were restored with ANDRO. The synaptic physiology data from brain slices showed that adults have more basal synaptic efficiency than ag …
Sociability was also not affected by age; however, social recognition and long-term memory were lower in the aged females than adults …
Differential Role of Sex and Age in the Synaptic Transmission of Degus (Octodon degus).
Oliva CA, Rivera DS, Mariqueo TA, Bozinovic F, Inestrosa NC. Oliva CA, et al. Among authors: inestrosa nc. Front Integr Neurosci. 2022 Feb 28;16:799147. doi: 10.3389/fnint.2022.799147. eCollection 2022. Front Integr Neurosci. 2022. PMID: 35295186 Free PMC article.
Furthermore, female and male degus develop significant but not different long-term synaptic plasticity (LTP). However, aged female degus need to recruit twice as many axons to evoke the same postsynaptic activity as male degus and four times more when compared to young fem …
Furthermore, female and male degus develop significant but not different long-term synaptic plasticity (LTP). However, aged female de …
A Multivariate Assessment of Age-Related Cognitive Impairment in Octodon degus.
Rivera DS, Lindsay CB, Oliva CA, Bozinovic F, Inestrosa NC. Rivera DS, et al. Among authors: inestrosa nc. Front Integr Neurosci. 2021 Aug 30;15:719076. doi: 10.3389/fnint.2021.719076. eCollection 2021. Front Integr Neurosci. 2021. PMID: 34526882 Free PMC article.
The purpose of this study is to outline the changes in age-related cognitive performance (i.e., short-term recognition memory and long-term learning and memory) in long-lived Octodon degus. ...Young animals formed a separate group of aged degus for both short- and l …
The purpose of this study is to outline the changes in age-related cognitive performance (i.e., short-term recognition memory and lon …
Neurodevelopmental impact of the offspring by thyroid hormone system-disrupting environmental chemicals during pregnancy.
Salazar P, Villaseca P, Cisternas P, Inestrosa NC. Salazar P, et al. Among authors: inestrosa nc. Environ Res. 2021 Sep;200:111345. doi: 10.1016/j.envres.2021.111345. Epub 2021 Jun 1. Environ Res. 2021. PMID: 34087190 Review.
The publications reviewed show: 1) known endocrine disruptors have an association with hormonal thyroid levels, where an effect of increase or decrease in TH concentrations has been reported depending on the chemical exposed 2) associations between TH, EDCs and neurocognitive dis …
The publications reviewed show: 1) known endocrine disruptors have an association with hormonal thyroid levels, where an effect of increase …
"Live together, die alone": The effect of re-socialization on behavioural performance and social-affective brain-related proteins after a long-term chronic social isolation stress.
Rivera DS, Lindsay CB, Oliva CA, Bozinovic F, Inestrosa NC. Rivera DS, et al. Among authors: inestrosa nc. Neurobiol Stress. 2020 Dec 29;14:100289. doi: 10.1016/j.ynstr.2020.100289. eCollection 2021 May. Neurobiol Stress. 2020. PMID: 33426200 Free PMC article.
Furthermore, social isolation has a negative impact on health and fitness. However, the neurobiological consequences of long-term chronic social isolation stress (LTCSIS) manifested during the adulthood of affected individuals are not fully understood. ...
Furthermore, social isolation has a negative impact on health and fitness. However, the neurobiological consequences of long-term chr …
Glutamatergic Receptor Trafficking and Delivery: Role of the Exocyst Complex.
Lira M, Mira RG, Carvajal FJ, Zamorano P, Inestrosa NC, Cerpa W. Lira M, et al. Among authors: inestrosa nc. Cells. 2020 Nov 3;9(11):2402. doi: 10.3390/cells9112402. Cells. 2020. PMID: 33153008 Free PMC article. Review.
In this review, we discuss the evidence so far published regarding receptor trafficking and the exocyst complex in both basal and stimulated levels, comparing constitutive trafficking and long-term potentiation-related trafficking....
In this review, we discuss the evidence so far published regarding receptor trafficking and the exocyst complex in both basal and stimulated …
Effects of long-lasting social isolation and re-socialization on cognitive performance and brain activity: a longitudinal study in Octodon degus.
Rivera DS, Lindsay CB, Oliva CA, Codocedo JF, Bozinovic F, Inestrosa NC. Rivera DS, et al. Among authors: inestrosa nc. Sci Rep. 2020 Oct 27;10(1):18315. doi: 10.1038/s41598-020-75026-4. Sci Rep. 2020. PMID: 33110163 Free PMC article.
Social isolation is considered a stressful situation that results in increased physiological reactivity to novel stimuli, altered behaviour, and impaired brain function. Here, we investigated the effects of long-term social isolation on working memory, spatial learning/mem …
Social isolation is considered a stressful situation that results in increased physiological reactivity to novel stimuli, altered behaviour, …
Hormetic-Like Effects of L-Homocysteine on Synaptic Structure, Function, and Aβ Aggregation.
Montecinos-Oliva C, Arrázola MS, Jara C, Tapia-Rojas C, Inestrosa NC. Montecinos-Oliva C, et al. Among authors: inestrosa nc. Pharmaceuticals (Basel). 2020 Feb 2;13(2):24. doi: 10.3390/ph13020024. Pharmaceuticals (Basel). 2020. PMID: 32024240 Free PMC article.
Finally, we studied the effects of HCy and HCy + Abeta(42) over long-term potentiation. Altogether, by studying an ample range of effects under different HCy concentrations, we report, for the first time, that HCy can exert beneficial or toxic effects over neurons, evidenc …
Finally, we studied the effects of HCy and HCy + Abeta(42) over long-term potentiation. Altogether, by studying an ample range of eff …
41 results