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Optical imaging reveals chemotherapy-induced metabolic reprogramming of residual disease and recurrence.
Sunassee ED, Deutsch RJ, D'Agostino VW, Castellano-Escuder P, Siebeneck EA, Ilkayeva O, Crouch BT, Madonna MC, Everitt J, Alvarez JV, Palmer GM, Hirschey MD, Ramanujam N. Sunassee ED, et al. Among authors: ilkayeva o. Sci Adv. 2024 Apr 5;10(14):eadj7540. doi: 10.1126/sciadv.adj7540. Epub 2024 Apr 5. Sci Adv. 2024. PMID: 38579004 Free PMC article.
Fewer than 20% of triple-negative breast cancer patients experience long-term responses to mainstay chemotherapy. Resistant tumor subpopulations use alternative metabolic pathways to escape therapy, survive, and eventually recur. ...
Fewer than 20% of triple-negative breast cancer patients experience long-term responses to mainstay chemotherapy. Resistant tumor sub …
Catabolism of fats and branched-chain amino acids in children with Type 1 diabetes: Association with glycaemic control and total daily insulin dose.
Hendrix G, Lokhnygina Y, Ramaker M, Ilkayeva O, Muehlbauer M, Evans W, Rasbach L, Benjamin R, Freemark M, Gumus Balikcioglu P. Hendrix G, et al. Among authors: ilkayeva o. Endocrinol Diabetes Metab. 2023 Nov;6(6):e448. doi: 10.1002/edm2.448. Epub 2023 Sep 16. Endocrinol Diabetes Metab. 2023. PMID: 37715520 Free PMC article.
However, insulin resistance (IR) may exacerbate glycaemic instability in T1D and contribute to long-term cardiovascular complications. We previously showed that IR in teenagers with obesity is associated with sex-dependent derangements in the catabolism of branched-chain a …
However, insulin resistance (IR) may exacerbate glycaemic instability in T1D and contribute to long-term cardiovascular complications …
In vivo metabolic imaging identifies lipid vulnerability in a preclinical model of Her2+/Neu breast cancer residual disease and recurrence.
Madonna MC, Duer JE, McKinney BJ, Sunassee ED, Crouch BT, Ilkayeva O, Hirschey MD, Alvarez JV, Ramanujam N. Madonna MC, et al. Among authors: ilkayeva o. NPJ Breast Cancer. 2022 Sep 26;8(1):111. doi: 10.1038/s41523-022-00481-3. NPJ Breast Cancer. 2022. PMID: 36163365 Free PMC article.
The temporal characteristics of metabolic reprogramming will be critical in determining the use of an appropriate timing for potential therapies; namely, the notion that metabolic-targeted inhibition during regression reports long-term therapeutic benefit....
The temporal characteristics of metabolic reprogramming will be critical in determining the use of an appropriate timing for potential thera …
Evaluating immune response and metabolic related biomarkers pre-allogenic hematopoietic stem cell transplant in acute myeloid leukemia.
Siamakpour-Reihani S, Cao F, Lyu J, Ren Y, Nixon AB, Xie J, Bush AT, Starr MD, Bain JR, Muehlbauer MJ, Ilkayeva O, Byers Kraus V, Huebner JL, Chao NJ, Sung AD. Siamakpour-Reihani S, et al. Among authors: ilkayeva o. PLoS One. 2022 Jun 14;17(6):e0268963. doi: 10.1371/journal.pone.0268963. eCollection 2022. PLoS One. 2022. PMID: 35700185 Free PMC article.
Using those samples (n = 34), we studied 65 blood based metabolomic and 61 immune/inflammatory related biomarkers, comparing patients with either long-term OS ( 3 years) or short-term OS (OS 1 years). We also compared the immune/inflammatory response and metabolomic …
Using those samples (n = 34), we studied 65 blood based metabolomic and 61 immune/inflammatory related biomarkers, comparing patients with e …
Maternal Metabolites Associated With Gestational Diabetes Mellitus and a Postpartum Disorder of Glucose Metabolism.
Liu Y, Kuang A, Bain JR, Muehlbauer MJ, Ilkayeva OR, Lowe LP, Metzger BE, Newgard CB, Scholtens DM, Lowe WL. Liu Y, et al. Among authors: ilkayeva or. J Clin Endocrinol Metab. 2021 Oct 21;106(11):3283-3294. doi: 10.1210/clinem/dgab513. J Clin Endocrinol Metab. 2021. PMID: 34255031 Free PMC article.
CONTEXT: Gestational diabetes is associated with a long-term risk of developing a disorder of glucose metabolism. However, neither the metabolic changes characteristic of gestational diabetes in a large, multi-ancestry cohort nor the ability of metabolic changes during pre …
CONTEXT: Gestational diabetes is associated with a long-term risk of developing a disorder of glucose metabolism. However, neither th …
Temporal dynamics of liver mitochondrial protein acetylation and succinylation and metabolites due to high fat diet and/or excess glucose or fructose.
Meyer JG, Softic S, Basisty N, Rardin MJ, Verdin E, Gibson BW, Ilkayeva O, Newgard CB, Kahn CR, Schilling B. Meyer JG, et al. Among authors: ilkayeva o. PLoS One. 2018 Dec 26;13(12):e0208973. doi: 10.1371/journal.pone.0208973. eCollection 2018. PLoS One. 2018. PMID: 30586434 Free PMC article.
To connect diet and molecular changes, here we performed short- and long-term feeding of mice with standard chow diet (SCD) and high-fat diet (HFD), with or without glucose or fructose supplementation, and quantified liver metabolites, 861 proteins, and 1,815 protein level …
To connect diet and molecular changes, here we performed short- and long-term feeding of mice with standard chow diet (SCD) and high- …
Cord Blood Metabolites Associated with Newborn Adiposity and Hyperinsulinemia.
Kadakia R, Scholtens DM, Rouleau GW, Talbot O, Ilkayeva OR, George T, Josefson JL. Kadakia R, et al. Among authors: ilkayeva or. J Pediatr. 2018 Dec;203:144-149.e1. doi: 10.1016/j.jpeds.2018.07.056. Epub 2018 Sep 10. J Pediatr. 2018. PMID: 30213459 Free PMC article.
OBJECTIVE: To evaluate the association between cord blood amino acid and acylcarnitine profiles and measures of adiposity and hyperinsulinemia in healthy newborns. STUDY DESIGN: A cross-sectional study of 118 full-term infants born to mothers without gestational diabetes w …
OBJECTIVE: To evaluate the association between cord blood amino acid and acylcarnitine profiles and measures of adiposity and hyperinsulinem …
Associations of maternal BMI and insulin resistance with the maternal metabolome and newborn outcomes.
Sandler V, Reisetter AC, Bain JR, Muehlbauer MJ, Nodzenski M, Stevens RD, Ilkayeva O, Lowe LP, Metzger BE, Newgard CB, Scholtens DM, Lowe WL Jr; HAPO Study Cooperative Research Group. Sandler V, et al. Among authors: ilkayeva o. Diabetologia. 2017 Mar;60(3):518-530. doi: 10.1007/s00125-016-4182-2. Epub 2016 Dec 16. Diabetologia. 2017. PMID: 27981358 Free PMC article.
AIMS/HYPOTHESIS: Maternal obesity increases the risk for large-for-gestational-age birth and excess newborn adiposity, which are associated with adverse long-term metabolic outcomes in offspring, probably due to effects mediated through the intrauterine environment. …
AIMS/HYPOTHESIS: Maternal obesity increases the risk for large-for-gestational-age birth and excess newborn adiposity, which are asso …
Prognostic Implications of Long-Chain Acylcarnitines in Heart Failure and Reversibility With Mechanical Circulatory Support.
Ahmad T, Kelly JP, McGarrah RW, Hellkamp AS, Fiuzat M, Testani JM, Wang TS, Verma A, Samsky MD, Donahue MP, Ilkayeva OR, Bowles DE, Patel CB, Milano CA, Rogers JG, Felker GM, O'Connor CM, Shah SH, Kraus WE. Ahmad T, et al. Among authors: ilkayeva or. J Am Coll Cardiol. 2016 Jan 26;67(3):291-9. doi: 10.1016/j.jacc.2015.10.079. J Am Coll Cardiol. 2016. PMID: 26796394 Free PMC article. Clinical Trial.
CONCLUSIONS: In chronic HF patients, circulating long-chain acylcarnitine metabolite levels were independently associated with adverse clinical outcomes and decreased after long-term mechanical circulatory support. These metabolites may serve as potential targets for new d …
CONCLUSIONS: In chronic HF patients, circulating long-chain acylcarnitine metabolite levels were independently associated with adverse clini …
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