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Tirzepatide attenuates mammary tumor progression in diet-induced obese mice.
Glenny EM, Ho AN, Kiesel VA, Chen F, Gates CE, Paules EM, Xu R, Holt CA, Coleman MF, Hursting SD. Glenny EM, et al. Among authors: hursting sd. bioRxiv [Preprint]. 2024 Jan 23:2024.01.20.576484. doi: 10.1101/2024.01.20.576484. bioRxiv. 2024. PMID: 38328151 Free PMC article. Preprint.
We report for the first time an anticancer benefit of tirzepatide-a dual glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide receptor agonist-in a model of obesity and breast cancer in female mice. Long-term tirzepatide treatment induced weight loss, m …
We report for the first time an anticancer benefit of tirzepatide-a dual glucagon-like peptide 1 and glucose-dependent insulinotropic polype …
Inflammation and Metabolism of Influenza-Stimulated Peripheral Blood Mononuclear Cells From Adults With Obesity Following Bariatric Surgery.
Green WD, Alwarawrah Y, Al-Shaer AE, Shi Q, Armstrong M, Manke J, Reisdorph N, Farrell TM, Hursting SD, MacIver NJ, Beck MA, Shaikh SR. Green WD, et al. Among authors: hursting sd. J Infect Dis. 2022 Dec 28;227(1):92-102. doi: 10.1093/infdis/jiac345. J Infect Dis. 2022. PMID: 35975968 Free PMC article.
We also investigated if impairments to PBMC metabolism were reversible upon short-term weight loss following bariatric surgery. RESULTS: Obesity was associated with systemic inflammation and poor inflammation resolution. ...CONCLUSIONS: These results show that obesity driv …
We also investigated if impairments to PBMC metabolism were reversible upon short-term weight loss following bariatric surgery. RESUL …
Cell Intrinsic and Systemic Metabolism in Tumor Immunity and Immunotherapy.
Coleman MF, Cozzo AJ, Pfeil AJ, Etigunta SK, Hursting SD. Coleman MF, et al. Among authors: hursting sd. Cancers (Basel). 2020 Apr 1;12(4):852. doi: 10.3390/cancers12040852. Cancers (Basel). 2020. PMID: 32244756 Free PMC article. Review.
Moreover, T cell activation and longevity within the tumor microenvironment are intimately tied to T cell metabolism and are required for the long-term efficacy of ICI therapy. We discuss in this review the intersection of metabolic competition in the tumor microenvironmen …
Moreover, T cell activation and longevity within the tumor microenvironment are intimately tied to T cell metabolism and are required for th …
Energy balance and obesity: what are the main drivers?
Romieu I, Dossus L, Barquera S, Blottière HM, Franks PW, Gunter M, Hwalla N, Hursting SD, Leitzmann M, Margetts B, Nishida C, Potischman N, Seidell J, Stepien M, Wang Y, Westerterp K, Winichagoon P, Wiseman M, Willett WC; IARC working group on Energy Balance and Obesity. Romieu I, et al. Among authors: hursting sd. Cancer Causes Control. 2017 Mar;28(3):247-258. doi: 10.1007/s10552-017-0869-z. Epub 2017 Feb 17. Cancer Causes Control. 2017. PMID: 28210884 Free PMC article.
Dietary patterns consistent with a traditional Mediterranean diet and other measures of diet quality can contribute to long-term weight control. Limiting consumption of sugar-sweetened beverages has a particularly important role in weight control. ...
Dietary patterns consistent with a traditional Mediterranean diet and other measures of diet quality can contribute to long-term weig …
Combination of a poxvirus-based vaccine with a cyclooxygenase-2 inhibitor (celecoxib) elicits antitumor immunity and long-term survival in CEA.Tg/MIN mice.
Zeytin HE, Patel AC, Rogers CJ, Canter D, Hursting SD, Schlom J, Greiner JW. Zeytin HE, et al. Among authors: hursting sd. Cancer Res. 2004 May 15;64(10):3668-78. doi: 10.1158/0008-5472.CAN-03-3878. Cancer Res. 2004. PMID: 15150127
Combining the CEA-based vaccine with the celecoxib-supplemented diet reduced tumor burden by 95% and significantly improved overall long-term survival. Both tumor reduction and improved overall survival were achieved without any evidence of autoimmunity directed at CEA-exp …
Combining the CEA-based vaccine with the celecoxib-supplemented diet reduced tumor burden by 95% and significantly improved overall long- …
Inhibition of rat mononuclear cell leukemia by corn oil gavage: in vivo, in situ and immune competence studies.
Hursting SD, Switzer BR, French JE, Kari FW. Hursting SD, et al. Carcinogenesis. 1994 Feb;15(2):193-9. doi: 10.1093/carcin/15.2.193. Carcinogenesis. 1994. PMID: 8313508
Corn oil administered by oral gavage decreases the spontaneous incidence of mononuclear cell leukemia (MNCL) in male Fischer rats used as vehicle controls in long-term carcinogenesis experiments. We used an MNCL transplant model, an in situ MNCL cell proliferation assay an …
Corn oil administered by oral gavage decreases the spontaneous incidence of mononuclear cell leukemia (MNCL) in male Fischer rats used as ve …